RGD Reference Report - Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection. - Rat Genome Database

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Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection.

Authors: Anderson, VE  Nguyen, Y  Weinberg, JB 
Citation: Anderson VE, etal., Virology. 2009 Aug 15;391(1):25-32. Epub 2009 Jun 28.
RGD ID: 4145637
Pubmed: PMID:19564030   (View Abstract at PubMed)
PMCID: PMC2759195   (View Article at PubMed Central)
DOI: DOI:10.1016/j.virol.2009.06.009   (Journal Full-text)

Virus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary environment may increase host susceptibility to infection. We used a cockroach antigen (CRA) model of allergic airway disease to test the hypothesis that Th2 cytokine overproduction increases susceptibility to mouse adenovirus type 1 (MAV-1). CRA sensitization led to upregulated lung expression of IL-4 and IL-13, lung cellular inflammation, and exaggerated airway mucus production. Following intranasal MAV-1 infection, lung cellular inflammation was more pronounced in CRA-sensitized mice than in unsensitized mice at 7 days post-infection but not at a later time point. CRA sensitization did not significantly suppress lung IFN-gamma expression, and lung IFN-gamma expression was upregulated in both CRA-sensitized mice and unsensitized mice over the course of MAV-1 infection. Despite CRA-induced differences in pulmonary inflammation, MAV-1 viral loads in lung and spleen and MAV-1 gene expression in the lung did not differ between CRA-sensitized and unsensitized mice. Our data therefore suggest that MAV-1 pathogenesis is not affected directly or indirectly by the Th2 polarization associated with allergic airway disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
respiratory allergy  ISOIl13 (Mus musculus)4145637; 4145637mRNA:increased expression:lungRGD 
respiratory allergy  IEP 4145637mRNA:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13  (interleukin 13)

Genes (Mus musculus)
Il13  (interleukin 13)

Genes (Homo sapiens)
IL13  (interleukin 13)


Additional Information