RGD Reference Report - The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis. - Rat Genome Database

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The role of cell-associated interleukin-1 in bleomycin-induced pulmonary fibrosis.

Authors: Asada, K  Ogushi, F  Tani, K  Maniwa, K  Ichikawa, W  Endo, T  Haung, L  Nishioka, Y  Sone, S  Ogura, T 
Citation: Asada K, etal., Tokushima J Exp Med. 1996 Dec;43(3-4):79-86.
RGD ID: 4142838
Pubmed: PMID:9100454   (View Abstract at PubMed)

The activities of cell-associated IL-1 (IL-1 alpha) and extracellular IL-1 (IL-1 beta) in alveolar macrophages (AM) from rats with bleomycin-induced pulmonary fibrolosis were measured to determine their role in fibroblast growth. AM were obtained on Days 1, 3, 6, 9 and 12 after a intratracheal injection of bleomycin, and the IL-1 activity and fibroblast growth-stimulating activity in fixed AM and AM supernatants were measured. Higher cell-associated IL-1 activity was detected in AM from bleomycin-treated rats than in those of control on Day 1 through 9. But extracellular IL-1 activity in the supernatant of AM from bleomycin-treated rats significantly higher only on Day 1. Expression of IL-1 alpha mRNA in AM from bleomycin-treated rats was significantly higher than that in AM of control, but there was no significant difference in the mRNA levels of IL-1 beta in AM of these two groups. Fixed AM from bleomycin-treated rats caused growth-inhibition of fibroblasts in a density-dependent manner. The inhibitory activity was decreased by pretreatment of fixed AM with anti IL-1 alpha antibody, but not anti IL-1 beta antibody. These results suggest that cell-associated IL-1 (IL-1 alpha) is produced continuously in AM from rats with bleomycin-induced pulmonary fibrosis and may be important in regulation of this disorder by inhibiting fibroblast growth.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary fibrosis  ISOIl1a (Rattus norvegicus)4142838; 4142838mRNA and protein:increased expression:alveolar macrophage:RGD 
pulmonary fibrosis  IEP 4142838mRNA and protein:increased expression:alveolar macrophageRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1a  (interleukin 1 alpha)

Genes (Mus musculus)
Il1a  (interleukin 1 alpha)

Genes (Homo sapiens)
IL1A  (interleukin 1 alpha)


Additional Information