RGD Reference Report - Neuregulin 1 Attenuates Neuronal Apoptosis Induced by Deep Hypothermic Circulatory Arrest Through ErbB4 Signaling in Rats. - Rat Genome Database

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Neuregulin 1 Attenuates Neuronal Apoptosis Induced by Deep Hypothermic Circulatory Arrest Through ErbB4 Signaling in Rats.

Authors: Li, Pengfei  Gu, Tianxiang  Wang, Chun  Zhang, Guangwei  Shi, Enyi 
Citation: Li P, etal., J Cardiovasc Pharmacol. 2015 Dec;66(6):551-7. doi: 10.1097/FJC.0000000000000303.
RGD ID: 405650401
Pubmed: PMID:26647012   (View Abstract at PubMed)
DOI: DOI:10.1097/FJC.0000000000000303   (Journal Full-text)

Mounting evidence suggests that neurological injury occurs after deep hypothermic circulatory arrest (DHCA), a protocol widely used in surgery for congenital heart diseases and aortic repair. Neuregulin 1 (NRG1), a neurotrophic factor highly expressed in the central nervous system, is crucial for neuronal survival. However, whether NRG1 is protective against apoptosis induced by DHCA is still unclear, as are the putative mechanisms involved. In this study, exogenous human NRG1 pretreatment (2.5 and 3.75 ng/kg, intracarotid injection) significantly inhibited neuronal apoptosis in DHCA-treated male rats, and notably, endogenous NRG1 expression was also increased. Bcl-2, as well as phosphorylated phosphatidylinositol-3-kinase, Akt, and cAMP-response element binding protein, were all increased, resulting in phosphorylation and subsequent activation of the ErbB4 receptor. Finally, expression of the apoptosis-related protein cleaved-caspase-3 was decreased, resulting in the inhibition of neuronal apoptosis induced by DHCA. Thus, our data indicate that NRG1 treatment inhibited DHCA-induced neuronal apoptosis by activating ErbB4 signaling, providing a potential therapeutic pathway for the prevention of neurological injury induced by DHCA.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ERBB4Humancardiac arrest treatmentISOErbb4 (Rattus norvegicus)associated with hypothermiaRGD 
Erbb4Ratcardiac arrest treatmentIEP associated with hypothermiaRGD 
Erbb4Mousecardiac arrest treatmentISOErbb4 (Rattus norvegicus)associated with hypothermiaRGD 
NRG1Humancardiac arrest treatmentISONrg1 (Rattus norvegicus)associated with hypothermiaRGD 
Nrg1Ratcardiac arrest treatmentIEP associated with hypothermiaRGD 
Nrg1Mousecardiac arrest treatmentISONrg1 (Rattus norvegicus)associated with hypothermiaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Nrg1  (neuregulin 1)

Genes (Mus musculus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)
Nrg1  (neuregulin 1)

Genes (Homo sapiens)
ERBB4  (erb-b2 receptor tyrosine kinase 4)
NRG1  (neuregulin 1)


Additional Information