RGD Reference Report - Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction Obese Rats. - Rat Genome Database

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Surgically Metabolic Resection of Pericardial Fat to Ameliorate Myocardial Mitochondrial Dysfunction in Acute Myocardial Infarction Obese Rats.

Authors: Kang, Ki-Woon  Ko, Ju-Young  Lee, Hyunghee  Shin, Seung Yong  Lee, Wang Soo  Hong, Joonhwa  Kim, Sang-Wook  Lee, Seong-Kyu  Oak, Min-Ho 
Citation: Kang KW, etal., J Korean Med Sci. 2022 Mar 7;37(9):e55. doi: 10.3346/jkms.2022.37.e55.
RGD ID: 401794445
Pubmed: PMID:35257523   (View Abstract at PubMed)
PMCID: PMC8901878   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.2022.37.e55   (Journal Full-text)


BACKGROUND: Pericardial fat (PF) is highly associated with cardiovascular disease but the effectiveness of surgical resection of PF is still unknown for myocardial mitochondrial structure and function in acute myocardial infarction (AMI) with obesity. The aim of this study was to demonstrate the difference in myocardial mitochondrial structure and function between obese AMI with additionally resected PF and those without resected PF.
METHODS: Obese rats with 12-week high fat diet (45 kcal% fat, n = 21) were randomly assigned into 3 groups: obese control, obese AMI and obese AMI with additionally resected PF. One week after developing AMI and additional resection of PF, echocardiogram, myocardial mitochondrial histomorphology, oxidative phosphorylation system (OXPHOS), anti-oxidative enzyme and sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) in the non-infarcted area were assessed between these groups.
RESULTS: There was significant improvement of systolic function in AMI with PF resection compared with the AMI group in the echocardiogram. Even though the electron microscopic morphology for the mitochondria seems to be similar between the AMI with PF resection and AMI groups, there was an improved expression of PGC-1α and responsive OXPHOS including NDUFB3, NDUFB5 and SDHB are associated with the ATP levels in the AMI with PF resection compared with those in the AMI group. In addition, the expression levels of antioxidant enzymes (MnSOD) and SERCA2 were improved in the AMI with PF resection compared with those in the AMI group.
CONCLUSION: Surgical resection of PF might ameliorate myocardial mitochondria dysfunction in obese AMI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute myocardial infarction amelioratesISONdufb5 (Rattus norvegicus)401794445; 401794445associated with obesityRGD 
acute myocardial infarction amelioratesIEP 401794445; 401794445associated with obesityRGD 
acute myocardial infarction amelioratesISOSdhb (Rattus norvegicus)401794445; 401794445associated with obesityRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ndufb5  (NADH:ubiquinone oxidoreductase subunit B5)
Sdhb  (succinate dehydrogenase complex iron sulfur subunit B)

Genes (Mus musculus)
Ndufb5  (NADH:ubiquinone oxidoreductase subunit B5)
Sdhb  (succinate dehydrogenase complex, subunit B, iron sulfur (Ip))

Genes (Homo sapiens)
NDUFB5  (NADH:ubiquinone oxidoreductase subunit B5)
SDHB  (succinate dehydrogenase complex iron sulfur subunit B)


Additional Information