RGD Reference Report - FOXP3 expression and clinical characteristics of hepatocellular carcinoma. - Rat Genome Database

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FOXP3 expression and clinical characteristics of hepatocellular carcinoma.

Authors: Wang, Wei-Hua  Jiang, Chang-Li  Yan, Wei  Zhang, Yu-Hai  Yang, Jiang-Tao  Zhang, Cun  Yan, Bo  Zhang, Wei  Han, Wei  Wang, Jun-Zhi  Zhang, Ying-Qi 
Citation: Wang WH, etal., World J Gastroenterol. 2010 Nov 21;16(43):5502-9. doi: 10.3748/wjg.v16.i43.5502.
RGD ID: 38548919
Pubmed: PMID:21086571   (View Abstract at PubMed)
PMCID: PMC2988246   (View Article at PubMed Central)
DOI: DOI:10.3748/wjg.v16.i43.5502   (Journal Full-text)


AIM: To study the biological and clinical characteristics of transcription factor forkhead box protein 3 (FOXP3) in hepatocellular carcinoma (HCC).
METHODS: We analyzed the expression and localization of FOXP3 in HCC tissues and cell lines to evaluate its biological features. The relationship between FOXP3 staining and clinical risk factors of HCC was assessed to identify the clinical characteristics of FOXP3 in HCC.
RESULTS: The mRNA and protein expression of FOXP3 were found in some hepatoma cell lines. Immunohistochemical (IHC) analysis of HCC sections revealed that 48% of HCC displayed FOXP3 staining, but we did not find any FOXP3 staining in normal liver tissues and para-tumor tissues. IHC and Confocal analysis showed that the expressions of FOXP3 were mainly present in the nucleus and cytoplasm of tumor cells in tissues or cell lines. In HCC, the distribution of FOXP3 was similar to that of the cirrhosis, but not to the hepatitis B virus. Those findings implicate that FOXP3 staining seems to be associated with the high risk of HCC.
CONCLUSION: The clinical characteristics of FOXP3 in HCC warrants further studies to explore its functions and roles in the cirrhosis and development of HCC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatitis B  IEP 38548919associated with hepatocellular carcinoma and protein:increased expression:liverRGD 
hepatitis B  ISOFOXP3 (Homo sapiens)38548919; 38548919associated with hepatocellular carcinoma and protein:increased expression:liverRGD 
hepatocellular carcinoma  IEP 38548919protein:increased expression:liverRGD 
hepatocellular carcinoma  ISOFOXP3 (Homo sapiens)38548919; 38548919protein:increased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Foxp3  (forkhead box P3)

Genes (Mus musculus)
Foxp3  (forkhead box P3)

Genes (Homo sapiens)
FOXP3  (forkhead box P3)


Additional Information