RGD Reference Report - Serum and ovarian Mullerian inhibiting substance, and their decline in reproductive aging. - Rat Genome Database

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Serum and ovarian Mullerian inhibiting substance, and their decline in reproductive aging.

Authors: Yeh, J  Kim, B  Peresie, J  Liang, YJ  Arroyo, A 
Citation: Yeh J, etal., Fertil Steril. 2007 May;87(5):1227-30. Epub 2007 Jan 12.
RGD ID: 2315641
Pubmed: PMID:17222835   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fertnstert.2006.11.011   (Journal Full-text)

The objectives of this study were to identify whether there is a decline in Mullerian inhibiting substance (MIS) in the female rat during chronological aging, and to define the physiological basis of aging-related changes in MIS. The results demonstrate that there is an exponential decline in both serum and ovarian levels of MIS with increasing female age, and that the histologic origin for the reduction in serum levels of MIS is a decline in the number of small ovarian follicles expressing MIS.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space  IDA 2315641 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Amh  (anti-Mullerian hormone)


Additional Information