RGD Reference Report - Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G. - Rat Genome Database

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Promotion of axon regeneration by myelin-associated glycoprotein and Nogo through divergent signals downstream of Gi/G.

Authors: Hasegawa, Y  Fujitani, M  Hata, K  Tohyama, M  Yamagishi, S  Yamashita, T 
Citation: Hasegawa Y, etal., J Neurosci. 2004 Jul 28;24(30):6826-32.
RGD ID: 2314970
Pubmed: PMID:15282288   (View Abstract at PubMed)
PMCID: PMC6729720   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.1856-04.2004   (Journal Full-text)

Several myelin-derived proteins have been identified as components of the CNS myelin that prevents axonal regeneration in the adult vertebrate CNS. Activation of RhoA has been shown to be an essential part of the signaling mechanism of these proteins. Here we report an additional signal, which determines whether these proteins promote or inhibit axon outgrowth. Myelin-associated glycoprotein (MAG) and Nogo trigger the intracellular elevation of Ca2+ as well as the activation of PKC, presumably mediated by G(i)/G. Neurite outgrowth inhibition and growth cone collapse by MAG or Nogo can be converted to neurite extension and growth cone spreading by inhibiting conventional PKC, but not by inhibiting inositol 1,4,5-triphosphate (IP3). Conversely, neurite growth of immature neurons promoted by MAG is abolished by inhibiting IP3. Activation of RhoA is independent of PKC. Thus, a balance between PKC and IP3 is important for bidirectional regulation of axon regeneration by the myelin-derived proteins.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of neuron projection development  IDA 2314970 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mag  (myelin-associated glycoprotein)

Objects referenced in this article
Gene Rtn4 reticulon 4 Rattus norvegicus

Additional Information