RGD Reference Report - Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity. - Rat Genome Database

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Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity.

Authors: Mori, Y  Tokutate, Y  Oana, F  Matsuzawa, A  Akahane, S  Tajima, N 
Citation: Mori Y, etal., J Atheroscler Thromb. 2004;11(4):224-31.
RGD ID: 2313517
Pubmed: PMID:15356383   (View Abstract at PubMed)

The effect of short-term bezafibrate (BF) administration over time on the expression of UCP mRNA in the tissues was examined in Otsuka Long Evans Tokushima Fatty (OLETF) rats. Eight-week-old rats were divided into a high-dose (100 mg/kg) BF group (n = 15), a low-dose (10 mg/kg) BF group (n = 15) and a control group (n = 15), and followed for 14 days. Feed intake by the high-dose BF group increased significantly between days 10 and 14 of administration. Triglyceride, free fatty acid, and T(4) levels decreased significantly in a dose-dependent manner in the high-dose BF group. Leptin and insulin levels significantly decreased on days 3 and 7. Throughout the study period, liver UCP2 mRNA increased in the high-dose BF group. On day 3 of BF administration, the levels of UCP2 mRNA expression in the skeletal muscles as well as UCP3 mRNA expression in the WAT were significantly increased in the high-dose BF group. PPAR-alpha mRNA significantly increased in the liver on day 3 of BF administration. We thus conclude that the PPAR-alpha-mediated effects of BF on the expression of liver UCP2 may be one of the factors that helped to decrease insulin levels.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  ISOUcp2 (Rattus norvegicus)2313517; 2313517associated with ObesityRGD 
type 2 diabetes mellitus  ISOUcp3 (Rattus norvegicus)2313517; 2313517associated with ObesityRGD 
type 2 diabetes mellitus  IDA 2313517; 2313517associated with ObesityRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ucp2  (uncoupling protein 2)
Ucp3  (uncoupling protein 3)

Genes (Mus musculus)
Ucp2  (uncoupling protein 2 (mitochondrial, proton carrier))
Ucp3  (uncoupling protein 3 (mitochondrial, proton carrier))

Genes (Homo sapiens)
UCP2  (uncoupling protein 2)
UCP3  (uncoupling protein 3)


Additional Information