Ucp3 (uncoupling protein 3 (mitochondrial, proton carrier)) - Rat Genome Database

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Gene: Ucp3 (uncoupling protein 3 (mitochondrial, proton carrier)) Mus musculus
Analyze
Symbol: Ucp3
Name: uncoupling protein 3 (mitochondrial, proton carrier)
RGD ID: 11474
MGI Page MGI
Description: Enables oxidative phosphorylation uncoupler activity and proton transmembrane transporter activity. Involved in lipid hydroperoxide transport and proton transmembrane transport. Acts upstream of or within fatty acid metabolic process and response to superoxide. Located in mitochondrial inner membrane. Is expressed in adipose tissue; heart; skeletal muscle; and telencephalon. Human ortholog(s) of this gene implicated in coronary restenosis; diabetic neuropathy; glucose metabolism disease (multiple); and obesity. Orthologous to human UCP3 (uncoupling protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI645527; mitochondrial uncoupling protein 3; putative mitochondrial transporter UCP3; Slc2; Slc25a9; solute carrier family 25 member 9; UCP 3; UCP-; UCP-3; uncoupling protein 3, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,122,198 - 100,135,639 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,122,197 - 100,135,639 (+)EnsemblGRCm39 Ensembl
GRCm387100,472,991 - 100,486,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,472,990 - 100,486,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,621,500 - 107,634,941 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,347,073 - 100,360,514 (+)NCBIMGSCv36mm8
Celera7100,810,580 - 100,824,026 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid A  (EXP,ISO)
ATP  (ISO)
beauvericin  (ISO)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
capsaicin  (ISO)
capsiate  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
ciglitazone  (EXP)
cisplatin  (ISO)
clofibrate  (EXP)
cordycepin  (ISO)
Cuprizon  (ISO)
D-glucose  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
Diosbulbin B  (EXP)
dioxygen  (EXP)
doxorubicin  (EXP,ISO)
enniatin  (ISO)
fenofibrate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
fructose  (ISO)
glucose  (ISO)
GW 7647  (EXP)
isoprenaline  (ISO)
kaempferol  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
lutein  (EXP)
methimazole  (ISO)
myo-inositol hexakisphosphate  (EXP)
nevirapine  (ISO)
ochratoxin A  (ISO)
oleic acid  (EXP,ISO)
ozone  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenformin  (ISO)
picolinic acid  (ISO)
picrotoxin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (EXP)
propanal  (ISO)
quercetin  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 203580  (EXP)
stavudine  (ISO)
streptozocin  (EXP)
T-2 toxin  (ISO)
telmisartan  (EXP)
testosterone  (EXP,ISO)
titanium dioxide  (EXP)
topiramate  (ISO)
triacsin C  (EXP)
trichloroethene  (EXP,ISO)
troglitazone  (EXP,ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. Argyropoulos G, etal., J Clin Invest. 1998 Oct 1;102(7):1345-51.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation. Bugger H, etal., Cancer Chemother Pharmacol. 2011 Jun;67(6):1381-8. doi: 10.1007/s00280-010-1441-7. Epub 2010 Aug 31.
4. Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Bugger H, etal., Diabetes. 2008 Nov;57(11):2924-32. Epub 2008 Aug 4.
5. Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. Casas F, etal., PLoS One. 2009 May 20;4(5):e5631. doi: 10.1371/journal.pone.0005631.
6. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. Choi CS, etal., J Clin Invest. 2007 Jul;117(7):1995-2003.
7. Concordant mRNA expression of UCP-3, but not UCP-2, with mitochondrial thioesterase-1 in brown adipose tissue and skeletal muscle in db/db diabetic mice. Clapham JC, etal., Biochem Biophys Res Commun. 2001 Oct 12;287(5):1058-62.
8. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Clapham JC, etal., Nature 2000 Jul 27;406(6794):415-8.
9. The uncoupling protein 3 -55 C -->T variant is not associated with Type II diabetes mellitus in Danish subjects. Dalgaard LT, etal., Diabetologia. 2001 Aug;44(8):1065-7.
10. A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. Du Z, etal., Hear Res. 2012 May;287(1-2):15-24. doi: 10.1016/j.heares.2012.04.012. Epub 2012 Apr 21.
11. Superoxide activates mitochondrial uncoupling proteins. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
12. Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats. Fukunaga Y, etal., J Hypertens. 2000 Sep;18(9):1233-8.
13. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. Gong DW, etal., J Biol Chem 2000 May 26;275(21):16251-7.
14. Linkage exclusion analysis of two candidate regions on chromosomes 7 and 11: leptin and UCP2/UCP3 are not QTLs for obesity in US Caucasians. Guo JJ, etal., Biochem Biophys Res Commun. 2005 Jul 1;332(2):602-8.
15. The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population. Hamada T, etal., Metabolism. 2008 Mar;57(3):410-5.
16. Decreased mitochondrial proton leak and reduced expression of uncoupling protein 3 in skeletal muscle of obese diet-resistant women. Harper ME, etal., Diabetes. 2002 Aug;51(8):2459-66.
17. Effects of streptozotocin-induced diabetes and insulin treatment on the hypothalamic melanocortin system and muscle uncoupling protein 3 expression in rats. Havel PJ, etal., Diabetes. 2000 Feb;49(2):244-52.
18. [UCP2 and UCP3 gene expression, heart function and oxygen cost of myocardial work changes during aging and ischemia-reperfusion] Hoshovs'ka IuV, etal., Fiziol Zh. 2009;55(3):26-36.
19. Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study. Hsu YH, etal., Diabetes. 2008 Apr;57(4):1101-7. Epub 2008 Jan 25.
20. An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort. Meirhaeghe A, etal., Diabetologia. 2000 Nov;43(11):1424-8.
21. Skeletal muscle uncoupling protein-3 restores upon intervention in the prediabetic and diabetic state: implications for diabetes pathogenesis? Mensink M, etal., Diabetes Obes Metab. 2007 Jul;9(4):594-6.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
24. MGD IEA MGD IEA
25. Bezafibrate-induced changes over time in the expression of uncoupling protein (UCP) mRNA in the tissues: a study in spontaneously type 2 diabetic rats with visceral obesity. Mori Y, etal., J Atheroscler Thromb. 2004;11(4):224-31.
26. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Nagai Y, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1180-90.
27. Association between obesity and insulin resistance with UCP2-UCP3 gene variants in Spanish children and adolescents. Ochoa MC, etal., Mol Genet Metab. 2007 Dec;92(4):351-8. Epub 2007 Sep 17.
28. Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries. Oguri M, etal., Int J Mol Med. 2007 Oct;20(4):533-8.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. Mouse MP Annotation Import Pipeline RGD automated import pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Rudofsky G Jr, etal., Diabetes Care. 2006 Jan;29(1):89-94.
34. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Ryu JW, etal., Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31.
35. Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes. Schrauwen P, etal., Diabetes. 2001 Dec;50(12):2870-3.
36. Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle. Son C, etal., Diabetologia. 2004 Jan;47(1):47-54. Epub 2003 Dec 12.
37. Roles of norepinephrine, free Fatty acids, thyroid status, and skeletal muscle uncoupling protein 3 expression in sympathomimetic-induced thermogenesis. Sprague JE, etal., J Pharmacol Exp Ther. 2007 Jan;320(1):274-80. Epub 2006 Sep 29.
38. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Walder K, etal., Hum Mol Genet. 1998 Sep;7(9):1431-5.
39. Enhanced diabetogenic effect of streptozotocin in mice overexpressing UCP-3 in skeletal muscle. Wang S, etal., Ann N Y Acad Sci. 2002 Jun;967:112-9.
40. Genomic modulation of mitochondrial respiratory genes in the hypertrophied heart reflects adaptive changes in mitochondrial and contractile function. Zungu M, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2819-25. Epub 2007 Aug 17.
Additional References at PubMed
PMID:9305858   PMID:9511737   PMID:9559644   PMID:9600108   PMID:9642158   PMID:9666083   PMID:9872400   PMID:10066417   PMID:10222258   PMID:10342807   PMID:10441518   PMID:10556422  
PMID:10748196   PMID:10767534   PMID:11239492   PMID:11256954   PMID:11259402   PMID:11274222   PMID:11350053   PMID:11595653   PMID:11707458   PMID:12032159   PMID:12096064   PMID:12115031  
PMID:12193161   PMID:12351640   PMID:12477932   PMID:12664076   PMID:12765967   PMID:12912909   PMID:14610273   PMID:14647371   PMID:14651853   PMID:14681479   PMID:15056934   PMID:15063757  
PMID:15496137   PMID:15814607   PMID:15922330   PMID:16084485   PMID:16180138   PMID:16306367   PMID:16337086   PMID:16434555   PMID:16455084   PMID:16857752   PMID:16966355   PMID:17347313  
PMID:17761668   PMID:17884810   PMID:18047787   PMID:18251717   PMID:18288636   PMID:18445701   PMID:18579531   PMID:18614015   PMID:18628202   PMID:18648851   PMID:18713955   PMID:18852040  
PMID:18854208   PMID:19041310   PMID:19101552   PMID:19176352   PMID:19598006   PMID:19954423   PMID:20089773   PMID:20206124   PMID:20227385   PMID:20360005   PMID:20363757   PMID:20399150  
PMID:20493945   PMID:20932228   PMID:21267068   PMID:21515686   PMID:21554247   PMID:21565164   PMID:21689632   PMID:21873635   PMID:22115550   PMID:22125598   PMID:22326222   PMID:22510273  
PMID:22693564   PMID:22912419   PMID:23335511   PMID:23457013   PMID:23597505   PMID:23688674   PMID:23690091   PMID:23825224   PMID:23907538   PMID:23968980   PMID:24141050   PMID:25103673  
PMID:25450611   PMID:25543145   PMID:25656576   PMID:25714676   PMID:25843654   PMID:25895476   PMID:26310111   PMID:26518386   PMID:26549555   PMID:26555260   PMID:26636187   PMID:26770648  
PMID:26915802   PMID:26965008   PMID:27166947   PMID:27185876   PMID:27218871   PMID:27317670   PMID:27371160   PMID:27473111   PMID:27647490   PMID:27871066   PMID:27983991   PMID:27997827  
PMID:28100774   PMID:28174343   PMID:28276603   PMID:28324027   PMID:29039450   PMID:29212043   PMID:29988383   PMID:30659802   PMID:31341297   PMID:31426456   PMID:32946628   PMID:33211703  
PMID:33663221   PMID:35081489   PMID:35237934   PMID:35452152   PMID:36114012   PMID:37225978   PMID:37295539   PMID:38254621  


Genomics

Comparative Map Data
Ucp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397100,122,198 - 100,135,639 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7100,122,197 - 100,135,639 (+)EnsemblGRCm39 Ensembl
GRCm387100,472,991 - 100,486,432 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7100,472,990 - 100,486,432 (+)EnsemblGRCm38mm10GRCm38
MGSCv377107,621,500 - 107,634,941 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367100,347,073 - 100,360,514 (+)NCBIMGSCv36mm8
Celera7100,810,580 - 100,824,026 (+)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.36NCBI
UCP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,000,277 - 74,009,085 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,000,277 - 74,009,085 (-)EnsemblGRCh38hg38GRCh38
GRCh371173,711,322 - 73,720,130 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,388,985 - 73,397,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 341173,392,374 - 73,397,778NCBI
Celera1171,018,129 - 71,027,086 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1170,007,226 - 70,016,183 (-)NCBIHuRef
CHM1_11173,595,177 - 73,604,136 (-)NCBICHM1_1
T2T-CHM13v2.01173,929,606 - 73,938,415 (-)NCBIT2T-CHM13v2.0
Ucp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81164,227,910 - 164,240,893 (+)NCBIGRCr8
mRatBN7.21154,815,777 - 154,828,764 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1154,815,777 - 154,828,762 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1162,810,789 - 162,823,741 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,990,890 - 170,003,842 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01162,864,787 - 162,877,739 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,482,912 - 165,495,895 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,482,155 - 165,496,206 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01171,683,566 - 171,697,139 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41157,896,001 - 157,909,608 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11157,974,793 - 157,988,399 (+)NCBI
Celera1152,898,320 - 152,911,676 (+)NCBICelera
RH 3.4 Map11258.1RGD
Cytogenetic Map1q32NCBI
Ucp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541417,558,889 - 17,578,737 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541417,558,889 - 17,578,108 (+)NCBIChiLan1.0ChiLan1.0
UCP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2974,941,880 - 74,953,797 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11175,986,899 - 75,998,075 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01169,072,143 - 69,085,424 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,380,180 - 72,389,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,380,180 - 72,389,274 (-)Ensemblpanpan1.1panPan2
UCP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12124,272,522 - 24,290,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2124,277,896 - 24,288,639 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2124,049,763 - 24,055,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02124,484,075 - 24,496,484 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2124,484,070 - 24,496,484 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12124,284,466 - 24,290,404 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02124,484,328 - 24,490,265 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02124,399,875 - 24,405,814 (+)NCBIUU_Cfam_GSD_1.0
Ucp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494761,482,972 - 61,496,412 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364983,082,575 - 3,095,737 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364983,082,575 - 3,095,739 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl98,378,021 - 8,386,211 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.198,378,023 - 8,389,452 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.299,167,483 - 9,178,955 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap9p21-p24NCBI
UCP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1165,269,611 - 65,279,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl165,269,607 - 65,278,807 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604360,587,459 - 60,596,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ucp3
480 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:967
Count of miRNA genes:475
Interacting mature miRNAs:549
Transcripts:ENSMUST00000032958, ENSMUST00000107059, ENSMUST00000128044, ENSMUST00000133850
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse
10412104Tons2_mtongue size 2 (mouse)Not determined799837716133837716Mouse

Markers in Region
AI645527  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387100,486,041 - 100,486,182UniSTSGRCm38
MGSCv377107,634,550 - 107,634,691UniSTSGRCm37
Celera7100,823,635 - 100,823,776UniSTS
Cytogenetic Map7E3UniSTS
cM Map750.0UniSTS
Whitehead/MRC_RH71022.95UniSTS
AB010742  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387100,485,909 - 100,486,038UniSTSGRCm38
MGSCv377107,634,418 - 107,634,547UniSTSGRCm37
Cytogenetic Map7E3UniSTS
cM Map750.0UniSTS
Whitehead/MRC_RH71024.04UniSTS
RH94827  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387100,485,133 - 100,485,286UniSTSGRCm38
MGSCv377107,633,642 - 107,633,795UniSTSGRCm37
Celera7100,822,723 - 100,822,876UniSTS
Cytogenetic Map7E3UniSTS
cM Map750.0UniSTS
Ucp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387100,480,215 - 100,480,591UniSTSGRCm38
MGSCv377107,634,527 - 107,635,092UniSTSGRCm37
Celera7100,817,812 - 100,818,188UniSTS
Cytogenetic Map7E3UniSTS
cM Map750.0UniSTS
cM Map750.0UniSTS
Ucp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm387100,486,018 - 100,486,583UniSTSGRCm38
MGSCv377107,634,527 - 107,635,092UniSTSGRCm37
Cytogenetic Map7E3UniSTS
cM Map750.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_009464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB008216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB010742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB011070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB013132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC117215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC151839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF019883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF030164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF032902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY965028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032958   ⟹   ENSMUSP00000032958
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7100,122,198 - 100,135,639 (+)Ensembl
GRCm38.p6 Ensembl7100,472,991 - 100,486,432 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107059   ⟹   ENSMUSP00000102674
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7100,122,200 - 100,134,513 (+)Ensembl
GRCm38.p6 Ensembl7100,472,993 - 100,485,306 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128044
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7100,122,197 - 100,134,633 (+)Ensembl
GRCm38.p6 Ensembl7100,472,990 - 100,485,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133850
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl7100,122,201 - 100,134,616 (+)Ensembl
GRCm38.p6 Ensembl7100,472,994 - 100,485,409 (+)Ensembl
RefSeq Acc Id: NM_009464   ⟹   NP_033490
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm397100,122,198 - 100,135,639 (+)NCBI
GRCm387100,472,991 - 100,486,432 (+)ENTREZGENE
MGSCv377107,621,500 - 107,634,941 (+)RGD
Celera7100,810,580 - 100,824,026 (+)RGD
cM Map7 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033490   ⟸   NM_009464
- UniProtKB: O88293 (UniProtKB/Swiss-Prot),   P56501 (UniProtKB/Swiss-Prot),   B2RTM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032958   ⟸   ENSMUST00000032958
RefSeq Acc Id: ENSMUSP00000102674   ⟸   ENSMUST00000107059

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56501-F1-model_v2 AlphaFold P56501 1-308 view protein structure

Promoters
RGD ID:8664917
Promoter ID:EPDNEW_M10490
Type:initiation region
Name:Ucp3_1
Description:Mus musculus uncoupling protein 3 (mitochondrial, proton carrier), mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm387100,472,969 - 100,473,029EPDNEW
RGD ID:6842302
Promoter ID:MM_KWN:51717
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000107059,   NM_009464,   OTTMUST00000054784,   OTTMUST00000054786
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367107,621,621 - 107,622,121 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1099787 AgrOrtholog
Ensembl Genes ENSMUSG00000032942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032958 ENTREZGENE
  ENSMUST00000032958.14 UniProtKB/Swiss-Prot
  ENSMUST00000107059.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Mit_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:22229 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1099787 ENTREZGENE
NCBI Gene 22229 ENTREZGENE
PANTHER MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MITOCHONDRIAL UNCOUPLING PROTEIN 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ucp3 PhenoGen
PRINTS MTUNCOUPLING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RTM2 ENTREZGENE, UniProtKB/TrEMBL
  O88293 ENTREZGENE
  P56501 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88293 UniProtKB/Swiss-Prot