RGD Reference Report - Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. - Rat Genome Database

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Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease.

Authors: Havens, AM  Chiu, E  Taba, M  Wang, J  Shiozawa, Y  Jung, Y  Taichman, LS  D'Silva, NJ  Gopalakrishnan, R  Wang, C  Giannobile, WV  Taichman, RS 
Citation: Havens AM, etal., J Periodontol. 2008 May;79(5):845-53.
RGD ID: 2306575
Pubmed: PMID:18454663   (View Abstract at PubMed)
PMCID: PMC2582372   (View Article at PubMed Central)
DOI: DOI:10.1902/jop.2008.070514   (Journal Full-text)

BACKGROUND: The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal cell-derived factor-1 (SDF-1alpha or CXC chemokine ligand 12) are involved in the trafficking of leukocytes into and out of extravascular tissues. The purpose of this study was to determine whether SDF-1alpha secreted by host cells plays a role in recruiting inflammatory cells into the periodontia during local inflammation. METHODS: SDF-1alpha levels were determined by enzyme-linked immunosorbent assay in gingival crevicular fluid (GCF) of 24 individuals with periodontitis versus healthy individuals in tissue biopsies and in a preclinical rat model of Porphyromonas gingivalis lipopolysaccharide-induced experimental bone loss. Neutrophil chemotaxis assays were also used to evaluate whether SDF-1alpha plays a role in the recruitment of host cells at periodontal lesions. RESULTS: Subjects with periodontal disease had higher levels of SDF-1alpha in their GCF compared to healthy subjects. Subjects with periodontal disease who underwent mechanical therapy demonstrated decreased levels of SDF-1alpha. Immunohistologic staining showed that SDF-1alpha and CXCR4 levels were elevated in samples obtained from periodontally compromised individuals. Similar results were observed in the rodent model. Neutrophil migration was enhanced in the presence of SDF-1alpha, mimicking immune cell migration in periodontal lesions. CONCLUSIONS: SDF-1alpha may be involved in the immune defense pathway activated during periodontal disease. Upon the development of diseased tissues, SDF-1alpha levels increase and may recruit host defensive cells into sites of inflammation. These studies suggest that SDF-1alpha may be a useful biomarker for the identification of periodontal disease progression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
periodontitis  IEP 2306575 RGD 
periodontitis  ISOCXCL12 (Homo sapiens)2306575; 2306575 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcl12  (C-X-C motif chemokine ligand 12)

Genes (Mus musculus)
Cxcl12  (C-X-C motif chemokine ligand 12)

Genes (Homo sapiens)
CXCL12  (C-X-C motif chemokine ligand 12)


Additional Information