RGD Reference Report - Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population.

Authors: Slowik, A  Wloch, D  Szermer, P  Wolkow, P  Malecki, M  Pera, J  Turaj, W  Dziedzic, T  Klimkowicz-Mrowiec, A  Kopec, G  Figlewicz, DA  Szczudlik, A 
Citation: Slowik A, etal., Cerebrovasc Dis. 2007;23(5-6):395-400. Epub 2007 Apr 2.
RGD ID: 1642614
Pubmed: PMID:17406108   (View Abstract at PubMed)
DOI: DOI:10.1159/000101462   (Journal Full-text)

BACKGROUND: Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke. METHODS: One hundred and thirty-six patients with large vessel disease (LVD) stroke, 140 with small vessel disease stroke, 272 with cardioembolic stroke, and their age- and sex-matched controls were included. PON genotypes were evaluated by PCR-RFLP analyses. RESULTS: The distribution of PON1 polymorphisms was similar in each stroke group and in the respective controls. Genotypes with the C allele of the PON2 gene C311S polymorphism were overrepresented in LVD stroke patients as compared with their controls, both in univariate and multivariate (dominant model: OR = 1.58, 95% CI: 1.006-2.48) analyses. CONCLUSION: The genotype with the C allele of the PON2 gene is a risk factor for LVD stroke in a Polish population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Stroke  IAGP 1642614large vessel disease (LVD) stroke and DNA:missense mutation:cds:p.C311S (human)RGD 
Stroke  ISOPON2 (Homo sapiens)1642614; 1642614large vessel disease (LVD) stroke and DNA:missense mutation:cds:p.C311S (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pon2  (paraoxonase 2)

Genes (Mus musculus)
Pon2  (paraoxonase 2)

Genes (Homo sapiens)
PON2  (paraoxonase 2)


Additional Information