PON2 (paraoxonase 2) - Rat Genome Database

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Gene: PON2 (paraoxonase 2) Homo sapiens
Analyze
Symbol: PON2
Name: paraoxonase 2
RGD ID: 1320575
HGNC Page HGNC:9205
Description: Enables identical protein binding activity. Involved in aromatic compound catabolic process. Located in plasma membrane. Implicated in several diseases, including cerebral infarction; familial hypercholesterolemia; neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A-esterase 2; aromatic esterase 2; arylesterase 2; paraoxonase nirs; PON 2; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Candidate Gene For: BW321_H
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,404,862 - 95,435,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl795,404,862 - 95,435,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37795,034,174 - 95,064,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,872,110 - 94,902,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34794,678,825 - 94,708,946NCBI
Celera789,732,873 - 89,763,084 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,641,241 - 89,671,460 (-)NCBIHuRef
CHM1_1794,964,201 - 94,994,411 (-)NCBICHM1_1
T2T-CHM13v2.0796,641,007 - 96,671,530 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
7-ketocholesterol  (ISO)
aconitine  (ISO)
acrolein  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
amiodarone  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atorvastatin calcium  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bilirubin IXalpha  (EXP)
bisphenol A  (ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
chlordecone  (ISO)
chlorpyrifos  (EXP,ISO)
chrysene  (ISO)
ciprofibrate  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (EXP)
coumarins  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
Diallyl sulfide  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diiodine  (ISO)
disodium selenite  (EXP)
doxorubicin  (EXP)
elemental selenium  (EXP)
ethanol  (ISO)
fenthion  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (EXP)
high-density lipoprotein cholesterol  (EXP)
hydrogen peroxide  (EXP,ISO)
isorhamnetin  (ISO)
ivermectin  (EXP)
ketoconazole  (EXP)
L-ascorbic acid  (EXP)
L-ethionine  (ISO)
lead diacetate  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (EXP)
miconazole  (ISO)
mithramycin  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-(3-oxododecanoyl)homoserine lactone  (EXP)
N-acetyl-beta-D-glucosamine  (EXP)
N-acetyl-D-glucosamine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
nicotine  (EXP)
omeprazole  (ISO)
paracetamol  (EXP)
parathion  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenyl acetate  (EXP)
phenylacetic acid  (EXP)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium perchlorate  (ISO)
Soman  (ISO)
sunitinib  (EXP)
superoxide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
tunicamycin  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Chen Q, etal., Am J Hum Genet. 2003 Jan;72(1):13-22. Epub 2002 Nov 26.
2. Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia. Choumerianou DM, etal., Clin Chem Lab Med. 2006;44(7):799-806.
3. Polymorphisms in the PON gene cluster are associated with Alzheimer disease. Erlich PM, etal., Hum Mol Genet. 2006 Jan 1;15(1):77-85. Epub 2005 Nov 30.
4. Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17 genes involved in methionine metabolism. Giusti B, etal., Thromb Haemost. 2010 Aug;104(2):231-42. doi: 10.1160/TH09-11-0748. Epub 2010 May 10.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. Hussein O, etal., Int J Hepatol. 2012;2012:265305. doi: 10.1155/2012/265305. Epub 2012 Mar 27.
7. Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias. Janka Z, etal., Mol Psychiatry. 2002;7(1):110-2.
8. Differential expression of adipose tissue proteins between obesity-susceptible and -resistant rats fed a high-fat diet. Joo JI, etal., Proteomics. 2011 Apr;11(8):1429-48. doi: 10.1002/pmic.201000515. Epub 2011 Feb 25.
9. Paraoxonase gene cluster is a genetic marker for early microvascular complications in type 1 diabetes. Kao Y, etal., Diabet Med. 2002 Mar;19(3):212-5.
10. Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population. Li XT, etal., J Occup Health. 2013;55(2):56-65. Epub 2013 Jan 18.
11. Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy. Mackness B, etal., Clin Sci (Lond). 2000 Mar;98(3):355-63.
12. Paraoxonase2 polymorphisms are associated with nephropathy in Type II diabetes. Pinizzotto M, etal., Diabetologia. 2001 Jan;44(1):104-7.
13. The Ser311Cys variation in the paraoxonase 2 gene increases the risk of type 2 diabetes in northern Chinese. Qu Y, etal., J Genet. 2008 Aug;87(2):165-9.
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
17. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Saeed M, etal., Neurology. 2006 Sep 12;67(5):771-6. Epub 2006 Jul 5.
18. DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease. Sanghera DK, etal., Am J Hum Genet. 1998 Jan;62(1):36-44.
19. Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population. Slowik A, etal., Cerebrovasc Dis. 2007;23(5-6):395-400. Epub 2007 Apr 2.
20. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics Wang XY, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Jun;20(3):215-9.
Additional References at PubMed
PMID:8661009   PMID:9329371   PMID:9714608   PMID:9847074   PMID:11257265   PMID:11512679   PMID:11579088   PMID:11676977   PMID:11692002   PMID:11768721   PMID:12082592   PMID:12151850  
PMID:12433026   PMID:12442067   PMID:12477932   PMID:12561466   PMID:12588779   PMID:12853948   PMID:12939804   PMID:12955589   PMID:14636952   PMID:14702039   PMID:14741412   PMID:14984433  
PMID:14996478   PMID:15001326   PMID:15039125   PMID:15166781   PMID:15232408   PMID:15256524   PMID:15345661   PMID:15359538   PMID:15489334   PMID:15544923   PMID:15607899   PMID:15772423  
PMID:15776585   PMID:16030523   PMID:16078734   PMID:16080611   PMID:16117861   PMID:16135439   PMID:16141008   PMID:16164576   PMID:16185677   PMID:16411107   PMID:16537434   PMID:16551349  
PMID:16614106   PMID:16767666   PMID:16822965   PMID:16891303   PMID:16926679   PMID:17096118   PMID:17137217   PMID:17299970   PMID:17309646   PMID:17353931   PMID:17404154   PMID:17412306  
PMID:17428620   PMID:17436100   PMID:17557249   PMID:17601350   PMID:17664137   PMID:17854416   PMID:17916643   PMID:17940058   PMID:18020951   PMID:18063859   PMID:18258817   PMID:18347034  
PMID:18361900   PMID:18413200   PMID:18427977   PMID:18436804   PMID:18513389   PMID:18569577   PMID:18635682   PMID:18691157   PMID:18695162   PMID:18720901   PMID:18759523   PMID:18818748  
PMID:18977241   PMID:18977341   PMID:19019335   PMID:19082953   PMID:19091699   PMID:19131662   PMID:19151417   PMID:19152805   PMID:19166692   PMID:19254215   PMID:19263529   PMID:19371607  
PMID:19401157   PMID:19479237   PMID:19490893   PMID:19497963   PMID:19527514   PMID:19540141   PMID:19546579   PMID:19575027   PMID:19578796   PMID:19587357   PMID:19654933   PMID:19818126  
PMID:19840942   PMID:19865538   PMID:19878569   PMID:19913121   PMID:19930448   PMID:19939821   PMID:19948975   PMID:20099504   PMID:20381198   PMID:20430392   PMID:20485444   PMID:20503442  
PMID:20529763   PMID:20530481   PMID:20536507   PMID:20565774   PMID:20582942   PMID:20628086   PMID:20839225   PMID:20934178   PMID:20980077   PMID:21118365   PMID:21127310   PMID:21145461  
PMID:21146823   PMID:21223581   PMID:21368884   PMID:21561808   PMID:21620813   PMID:21672555   PMID:21757906   PMID:21765051   PMID:21873635   PMID:21988832   PMID:22016051   PMID:22174317  
PMID:22183305   PMID:22190034   PMID:22268729   PMID:22354994   PMID:22534874   PMID:22744335   PMID:22810586   PMID:22860094   PMID:22939629   PMID:22964087   PMID:23053877   PMID:23225229  
PMID:23487294   PMID:23742759   PMID:23798571   PMID:23979707   PMID:24088404   PMID:24100645   PMID:24189400   PMID:24301778   PMID:24421402   PMID:24636586   PMID:24727057   PMID:24797263  
PMID:24807171   PMID:24816800   PMID:24845160   PMID:25038992   PMID:25210784   PMID:25708945   PMID:25740199   PMID:25913154   PMID:25953737   PMID:25991559   PMID:26056385   PMID:26186194  
PMID:26227792   PMID:26496610   PMID:26656916   PMID:26978533   PMID:27322774   PMID:27578362   PMID:27609416   PMID:27623343   PMID:27771368   PMID:28108734   PMID:28430636   PMID:28433610  
PMID:28509526   PMID:28514442   PMID:28566152   PMID:28611215   PMID:28637359   PMID:28675297   PMID:28768768   PMID:28803777   PMID:28862184   PMID:29117863   PMID:29308836   PMID:29439952  
PMID:29507755   PMID:29531225   PMID:29568061   PMID:29656893   PMID:29729330   PMID:30022168   PMID:30138371   PMID:30607774   PMID:30833792   PMID:31091453   PMID:31182584   PMID:31338708  
PMID:31536960   PMID:31835890   PMID:31871319   PMID:31980649   PMID:32306677   PMID:32344865   PMID:32355176   PMID:32382056   PMID:32409323   PMID:32614325   PMID:32707033   PMID:33001583  
PMID:33144569   PMID:33210737   PMID:33531346   PMID:33545068   PMID:33567341   PMID:33957083   PMID:33961781   PMID:34079125   PMID:34709727   PMID:34710487   PMID:34987135   PMID:35092416  
PMID:35241646   PMID:35271311   PMID:35286330   PMID:35460610   PMID:35696571   PMID:35944360   PMID:36076661   PMID:36114006   PMID:36180527   PMID:36215168   PMID:36610398   PMID:36613780  
PMID:36653584   PMID:36779763   PMID:36840500   PMID:36897549   PMID:38397445  


Genomics

Comparative Map Data
PON2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38795,404,862 - 95,435,028 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl795,404,862 - 95,435,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37795,034,174 - 95,064,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36794,872,110 - 94,902,320 (-)NCBINCBI36Build 36hg18NCBI36
Build 34794,678,825 - 94,708,946NCBI
Celera789,732,873 - 89,763,084 (-)NCBICelera
Cytogenetic Map7q21.3NCBI
HuRef789,641,241 - 89,671,460 (-)NCBIHuRef
CHM1_1794,964,201 - 94,994,411 (-)NCBICHM1_1
T2T-CHM13v2.0796,641,007 - 96,671,530 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)NCBI
Pon2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3965,264,620 - 5,298,408 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm39 Ensembl
GRCm3865,264,620 - 5,298,345 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl65,264,147 - 5,298,455 (-)EnsemblGRCm38mm10GRCm38
MGSCv3765,214,624 - 5,248,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3665,214,624 - 5,248,373 (-)NCBIMGSCv36mm8
Celera65,411,917 - 5,445,790 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map61.99NCBI
Pon2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8434,356,270 - 34,391,684 (-)NCBIGRCr8
mRatBN7.2433,389,702 - 33,425,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl433,389,714 - 33,425,248 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx438,348,742 - 38,384,154 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0434,274,880 - 34,310,296 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0432,684,666 - 32,720,086 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0430,344,705 - 30,380,119 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl430,344,709 - 30,380,119 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0430,251,589 - 30,287,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4430,033,229 - 30,068,643 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1430,072,559 - 30,107,973 (-)NCBI
Celera428,916,533 - 28,951,951 (-)NCBICelera
Cytogenetic Map4q21NCBI
Pon2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543211,987,919 - 12,020,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543211,988,009 - 12,020,702 (-)NCBIChiLan1.0ChiLan1.0
PON2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26113,247,154 - 113,277,476 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17161,511,793 - 161,542,058 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0787,362,447 - 87,392,795 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17100,950,074 - 100,980,433 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7100,950,074 - 100,980,433 (-)Ensemblpanpan1.1panPan2
PON2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11420,652,905 - 20,680,945 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1420,652,905 - 20,680,980 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1420,212,086 - 20,240,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01420,475,174 - 20,503,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1420,474,039 - 20,503,262 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11420,619,843 - 20,648,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01420,355,194 - 20,383,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01420,612,464 - 20,640,503 (-)NCBIUU_Cfam_GSD_1.0
Pon2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511833,969,230 - 34,000,895 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365854,862,364 - 4,895,323 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365854,862,378 - 4,894,061 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PON2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl975,027,097 - 75,051,422 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1975,027,270 - 75,051,441 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2982,405,444 - 82,429,620 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PON2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12153,607,353 - 53,637,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2153,607,541 - 53,639,896 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604250,709,094 - 50,738,898 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pon2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248132,053,310 - 2,086,086 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248132,055,871 - 2,086,046 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PON2
41 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000305.3(PON2):c.932C>G (p.Ser311Cys) single nucleotide variant PARAOXONASE 2 POLYMORPHISM [RCV000007500]|not provided [RCV001723548] Chr7:95405463 [GRCh38]
Chr7:95034775 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.443C>G (p.Ala148Gly) single nucleotide variant PARAOXONASE 2 POLYMORPHISM [RCV000007501]|not provided [RCV001723549] Chr7:95411704 [GRCh38]
Chr7:95041016 [GRCh37]
Chr7:7q21.3
benign
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
NM_000305.2(PON2):c.201+550G>T single nucleotide variant Lung cancer [RCV000106696] Chr7:95415692 [GRCh38]
Chr7:95045004 [GRCh37]
Chr7:7q21.3
uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3(chr7:95127070-97873487)x1 copy number loss See cases [RCV000135435] Chr7:95127070..97873487 [GRCh38]
Chr7:94756382..97502799 [GRCh37]
Chr7:94594318..97340735 [NCBI36]
Chr7:7q21.3
pathogenic
GRCh38/hg38 7q21.2-21.3(chr7:92759144-97568646)x1 copy number loss See cases [RCV000141756] Chr7:92759144..97568646 [GRCh38]
Chr7:92388458..97197958 [GRCh37]
Chr7:92226394..97035894 [NCBI36]
Chr7:7q21.2-21.3
pathogenic
NM_000305.3(PON2):c.-5G>A single nucleotide variant not provided [RCV000588428] Chr7:95434956 [GRCh38]
Chr7:95064268 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.610GTT[1] (p.Val205del) microsatellite not specified [RCV000590448] Chr7:95409981..95409983 [GRCh38]
Chr7:95039293..95039295 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.885G>A (p.Pro295=) single nucleotide variant not provided [RCV000586883] Chr7:95406140 [GRCh38]
Chr7:95035452 [GRCh37]
Chr7:7q21.3
likely benign
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q21.3(chr7:94309218-95455621)x3 copy number gain See cases [RCV000448904] Chr7:94309218..95455621 [GRCh37]
Chr7:7q21.3
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split hand-foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
Chr7:7q21.2-22.1
pathogenic
GRCh37/hg19 7q21.3(chr7:93285237-96280817)x1 copy number loss not provided [RCV000682901] Chr7:93285237..96280817 [GRCh37]
Chr7:7q21.3
pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q21.3(chr7:93700162-96950914)x1 copy number loss not provided [RCV000746898] Chr7:93700162..96950914 [GRCh37]
Chr7:7q21.3
pathogenic
NM_000305.3(PON2):c.778-23T>A single nucleotide variant not provided [RCV001609866] Chr7:95406270 [GRCh38]
Chr7:95035582 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.777+166T>A single nucleotide variant not provided [RCV001678983] Chr7:95406821 [GRCh38]
Chr7:95036133 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.368-180G>A single nucleotide variant not provided [RCV001645439] Chr7:95411959 [GRCh38]
Chr7:95041271 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.495-32G>A single nucleotide variant not provided [RCV001666656] Chr7:95410133 [GRCh38]
Chr7:95039445 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.201+296G>C single nucleotide variant not provided [RCV001648090] Chr7:95415946 [GRCh38]
Chr7:95045258 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.471A>G (p.Thr157=) single nucleotide variant not provided [RCV000897391] Chr7:95411676 [GRCh38]
Chr7:95040988 [GRCh37]
Chr7:7q21.3
likely benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_000305.3(PON2):c.708T>G (p.Val236=) single nucleotide variant not provided [RCV000923954]|not specified [RCV003479248] Chr7:95407056 [GRCh38]
Chr7:95036368 [GRCh37]
Chr7:7q21.3
benign|likely benign
NM_000305.3(PON2):c.358A>G (p.Ile120Val) single nucleotide variant not provided [RCV000896009] Chr7:95412321 [GRCh38]
Chr7:95041633 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.725A>G (p.His242Arg) single nucleotide variant Inborn genetic diseases [RCV003291194] Chr7:95407039 [GRCh38]
Chr7:95036351 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.456G>A (p.Leu152=) single nucleotide variant not provided [RCV000886646]|not specified [RCV002282398] Chr7:95411691 [GRCh38]
Chr7:95041003 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.375A>G (p.Thr125=) single nucleotide variant not provided [RCV000979246] Chr7:95411772 [GRCh38]
Chr7:95041084 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.514G>C (p.Val172Leu) single nucleotide variant not provided [RCV000969217] Chr7:95410082 [GRCh38]
Chr7:95039394 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.695+14T>C single nucleotide variant not specified [RCV001174876] Chr7:95409887 [GRCh38]
Chr7:95039199 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.75-231del deletion not provided [RCV001656327] Chr7:95424816 [GRCh38]
Chr7:95054128 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.367+82C>A single nucleotide variant not provided [RCV001687480] Chr7:95412230 [GRCh38]
Chr7:95041542 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.907-21T>A single nucleotide variant not provided [RCV001635648] Chr7:95405509 [GRCh38]
Chr7:95034821 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.293G>A (p.Arg98Gln) single nucleotide variant not specified [RCV001194159] Chr7:95412386 [GRCh38]
Chr7:95041698 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.75-110A>C single nucleotide variant not provided [RCV001666900] Chr7:95424695 [GRCh38]
Chr7:95054007 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.677A>G (p.Asn226Ser) single nucleotide variant not specified [RCV001201183] Chr7:95409919 [GRCh38]
Chr7:95039231 [GRCh37]
Chr7:7q21.3
likely benign
GRCh37/hg19 7q21.3(chr7:93516132-95668733) copy number loss Myoclonic dystonia 11 [RCV001254167] Chr7:93516132..95668733 [GRCh37]
Chr7:7q21.3
pathogenic
NM_000305.3(PON2):c.75-20dup duplication not specified [RCV001255526] Chr7:95424596..95424597 [GRCh38]
Chr7:95053908..95053909 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.286del (p.Arg96fs) deletion not specified [RCV001280650] Chr7:95412393 [GRCh38]
Chr7:95041705 [GRCh37]
Chr7:7q21.3
uncertain significance
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_000305.3(PON2):c.884C>T (p.Pro295Leu) single nucleotide variant not provided [RCV001357197] Chr7:95406141 [GRCh38]
Chr7:95035453 [GRCh37]
Chr7:7q21.3
uncertain significance
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1
pathogenic
NM_000305.3(PON2):c.195del (p.Phe65fs) deletion not specified [RCV001269193] Chr7:95416248 [GRCh38]
Chr7:95045560 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.201+247G>T single nucleotide variant not provided [RCV001694037] Chr7:95415995 [GRCh38]
Chr7:95045307 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.900G>A (p.Ser300=) single nucleotide variant not specified [RCV001733364] Chr7:95406125 [GRCh38]
Chr7:95035437 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.287G>C (p.Arg96Thr) single nucleotide variant not specified [RCV001779454] Chr7:95412392 [GRCh38]
Chr7:95041704 [GRCh37]
Chr7:7q21.3
likely benign
GRCh37/hg19 7q21.3(chr7:94309218-95455621) copy number gain not specified [RCV002053710] Chr7:94309218..95455621 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.695+7C>T single nucleotide variant not specified [RCV003236408] Chr7:95409894 [GRCh38]
Chr7:95039206 [GRCh37]
Chr7:7q21.3
uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3
uncertain significance
GRCh37/hg19 7q21.2-22.1(chr7:92721627-98311537)x1 copy number loss not provided [RCV002474498] Chr7:92721627..98311537 [GRCh37]
Chr7:7q21.2-22.1
pathogenic
NM_000305.3(PON2):c.195T>C (p.Phe65=) single nucleotide variant not specified [RCV002302460] Chr7:95416248 [GRCh38]
Chr7:95045560 [GRCh37]
Chr7:7q21.3
benign
NM_000305.3(PON2):c.344G>A (p.Gly115Asp) single nucleotide variant Inborn genetic diseases [RCV002731770] Chr7:95412335 [GRCh38]
Chr7:95041647 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.202G>A (p.Gly68Ser) single nucleotide variant Inborn genetic diseases [RCV002907541] Chr7:95412477 [GRCh38]
Chr7:95041789 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.370G>A (p.Asp124Asn) single nucleotide variant Inborn genetic diseases [RCV002788336] Chr7:95411777 [GRCh38]
Chr7:95041089 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.570A>C (p.Leu190Phe) single nucleotide variant Inborn genetic diseases [RCV002812386] Chr7:95410026 [GRCh38]
Chr7:95039338 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.236C>T (p.Pro79Leu) single nucleotide variant Inborn genetic diseases [RCV002944995] Chr7:95412443 [GRCh38]
Chr7:95041755 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.832G>A (p.Asp278Asn) single nucleotide variant Inborn genetic diseases [RCV003192713] Chr7:95406193 [GRCh38]
Chr7:95035505 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.311G>T (p.Arg104Leu) single nucleotide variant Inborn genetic diseases [RCV003211809] Chr7:95412368 [GRCh38]
Chr7:95041680 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.218G>C (p.Gly73Ala) single nucleotide variant Inborn genetic diseases [RCV003183925] Chr7:95412461 [GRCh38]
Chr7:95041773 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.75-4A>G single nucleotide variant not specified [RCV003324342] Chr7:95424589 [GRCh38]
Chr7:95053901 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.310C>T (p.Arg104Cys) single nucleotide variant not specified [RCV003324343] Chr7:95412369 [GRCh38]
Chr7:95041681 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.-15C>T single nucleotide variant not specified [RCV003324344] Chr7:95434966 [GRCh38]
Chr7:95064278 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.660T>C (p.Asp220=) single nucleotide variant not specified [RCV003331907] Chr7:95409936 [GRCh38]
Chr7:95039248 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.*4G>A single nucleotide variant not specified [RCV003331633] Chr7:95405326 [GRCh38]
Chr7:95034638 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.873C>T (p.Phe291=) single nucleotide variant not specified [RCV003331660] Chr7:95406152 [GRCh38]
Chr7:95035464 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.139G>A (p.Gly47Arg) single nucleotide variant not specified [RCV003331908] Chr7:95424521 [GRCh38]
Chr7:95053833 [GRCh37]
Chr7:7q21.3
uncertain significance
GRCh37/hg19 7q21.3(chr7:94813388-96264152)x1 copy number loss not provided [RCV003482969] Chr7:94813388..96264152 [GRCh37]
Chr7:7q21.3
pathogenic
NM_000305.3(PON2):c.698A>G (p.Tyr233Cys) single nucleotide variant not specified [RCV003479641] Chr7:95407066 [GRCh38]
Chr7:95036378 [GRCh37]
Chr7:7q21.3
uncertain significance
NM_000305.3(PON2):c.-52C>G single nucleotide variant not provided [RCV003433943] Chr7:95435003 [GRCh38]
Chr7:95064315 [GRCh37]
Chr7:7q21.3
likely benign
NM_000305.3(PON2):c.359T>G (p.Ile120Arg) single nucleotide variant not specified [RCV003489674] Chr7:95412320 [GRCh38]
Chr7:95041632 [GRCh37]
Chr7:7q21.3
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2498
Count of miRNA genes:919
Interacting mature miRNAs:1071
Transcripts:ENST00000222572, ENST00000433091, ENST00000446142, ENST00000455123, ENST00000459842, ENST00000460873, ENST00000469716, ENST00000469926, ENST00000471883, ENST00000478801, ENST00000483292, ENST00000490778, ENST00000491069, ENST00000493290, ENST00000493469, ENST00000536183
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D7S2091E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,034,268 - 95,034,439UniSTSGRCh37
Build 36794,872,204 - 94,872,375RGDNCBI36
Celera789,732,967 - 89,733,138RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,641,335 - 89,641,506UniSTS
CRA_TCAGchr7v2794,363,263 - 94,363,434UniSTS
GeneMap99-GB4 RH Map7490.21UniSTS
RH45934  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,043,777 - 95,043,945UniSTSGRCh37
Build 36794,881,713 - 94,881,881RGDNCBI36
Celera789,742,473 - 89,742,641RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,650,838 - 89,651,006UniSTS
CRA_TCAGchr7v2794,372,769 - 94,372,937UniSTS
GeneMap99-GB4 RH Map7497.67UniSTS
NCBI RH Map71038.0UniSTS
D7S2922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,034,550 - 95,034,683UniSTSGRCh37
Build 36794,872,486 - 94,872,619RGDNCBI36
Celera789,733,249 - 89,733,382RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,641,617 - 89,641,750UniSTS
CRA_TCAGchr7v2794,363,545 - 94,363,678UniSTS
RH103375  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,036,554 - 95,036,698UniSTSGRCh37
Build 36794,874,490 - 94,874,634RGDNCBI36
Celera789,735,253 - 89,735,397RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,643,621 - 89,643,765UniSTS
CRA_TCAGchr7v2794,365,549 - 94,365,693UniSTS
GeneMap99-GB4 RH Map7492.54UniSTS
RH121983  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,043,842 - 95,044,085UniSTSGRCh37
Build 36794,881,778 - 94,882,021RGDNCBI36
Celera789,742,538 - 89,742,781RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,650,903 - 89,651,146UniSTS
CRA_TCAGchr7v2794,372,834 - 94,373,077UniSTS
TNG Radiation Hybrid Map741417.0UniSTS
D7S2405  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,034,270 - 95,034,389UniSTSGRCh37
Build 36794,872,206 - 94,872,325RGDNCBI36
Celera789,732,969 - 89,733,088RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,641,337 - 89,641,456UniSTS
CRA_TCAGchr7v2794,363,265 - 94,363,384UniSTS
WI-12654  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,048,014 - 95,048,148UniSTSGRCh37
Build 36794,885,950 - 94,886,084RGDNCBI36
Celera789,746,710 - 89,746,844RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,655,086 - 89,655,220UniSTS
CRA_TCAGchr7v2794,377,006 - 94,377,140UniSTS
GeneMap99-GB4 RH Map7494.49UniSTS
Whitehead-RH Map7462.9UniSTS
RH45355  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37795,047,333 - 95,047,454UniSTSGRCh37
Build 36794,885,269 - 94,885,390RGDNCBI36
Celera789,746,029 - 89,746,150RGD
Cytogenetic Map7q21.3UniSTS
HuRef789,654,405 - 89,654,526UniSTS
CRA_TCAGchr7v2794,376,325 - 94,376,446UniSTS
GeneMap99-GB4 RH Map7492.54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2419 2112 1719 623 762 464 3776 1492 3724 389 1457 1590 175 1 1203 2208 6 2
Low 20 840 7 1 1091 1 581 705 7 30 3 19 1 580
Below cutoff 39 66 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001018161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017012358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054358476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB102891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC004012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC005021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF001603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY210982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC040010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC046160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB961097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L48513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000222572   ⟹   ENSP00000222572
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,404,862 - 95,435,028 (-)Ensembl
RefSeq Acc Id: ENST00000433091   ⟹   ENSP00000404622
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,404,880 - 95,435,198 (-)Ensembl
RefSeq Acc Id: ENST00000446142   ⟹   ENSP00000405211
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,405,339 - 95,434,976 (-)Ensembl
RefSeq Acc Id: ENST00000455123   ⟹   ENSP00000414515
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,404,867 - 95,434,991 (-)Ensembl
RefSeq Acc Id: ENST00000459842
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,409,507 - 95,411,684 (-)Ensembl
RefSeq Acc Id: ENST00000460873
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,412,744 - 95,434,951 (-)Ensembl
RefSeq Acc Id: ENST00000469716
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,424,164 - 95,435,028 (-)Ensembl
RefSeq Acc Id: ENST00000469926   ⟹   ENSP00000488550
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,409,997 - 95,434,998 (-)Ensembl
RefSeq Acc Id: ENST00000471883
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,418,176 - 95,435,030 (-)Ensembl
RefSeq Acc Id: ENST00000478801   ⟹   ENSP00000487703
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,412,324 - 95,434,951 (-)Ensembl
RefSeq Acc Id: ENST00000483292   ⟹   ENSP00000488874
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,405,278 - 95,411,703 (-)Ensembl
RefSeq Acc Id: ENST00000490778   ⟹   ENSP00000488826
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,411,682 - 95,435,126 (-)Ensembl
RefSeq Acc Id: ENST00000491069   ⟹   ENSP00000488462
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,411,651 - 95,434,951 (-)Ensembl
RefSeq Acc Id: ENST00000493290   ⟹   ENSP00000488822
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,411,730 - 95,435,009 (-)Ensembl
RefSeq Acc Id: ENST00000493469
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,415,876 - 95,434,963 (-)Ensembl
RefSeq Acc Id: ENST00000632034   ⟹   ENSP00000487898
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,411,704 - 95,435,008 (-)Ensembl
RefSeq Acc Id: ENST00000633192   ⟹   ENSP00000488378
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,404,897 - 95,435,329 (-)Ensembl
RefSeq Acc Id: ENST00000633531   ⟹   ENSP00000488838
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl795,404,863 - 95,435,072 (-)Ensembl
RefSeq Acc Id: NM_000305   ⟹   NP_000296
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,404,862 - 95,435,028 (-)NCBI
GRCh37795,034,174 - 95,064,636 (-)NCBI
Build 36794,872,110 - 94,902,320 (-)NCBI Archive
HuRef789,641,241 - 89,671,460 (-)ENTREZGENE
CHM1_1794,964,201 - 94,994,411 (-)NCBI
T2T-CHM13v2.0796,641,007 - 96,671,177 (-)NCBI
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001018161   ⟹   NP_001018171
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,404,862 - 95,435,028 (-)NCBI
GRCh37795,034,174 - 95,064,636 (-)NCBI
Build 36794,872,110 - 94,902,320 (-)NCBI Archive
HuRef789,641,241 - 89,671,460 (-)ENTREZGENE
CHM1_1794,964,201 - 94,994,411 (-)NCBI
T2T-CHM13v2.0796,641,007 - 96,671,177 (-)NCBI
CRA_TCAGchr7v2794,363,169 - 94,393,380 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: XM_005250453   ⟹   XP_005250510
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,404,862 - 95,424,573 (-)NCBI
GRCh37795,034,174 - 95,064,636 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017012357   ⟹   XP_016867846
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,404,862 - 95,416,297 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054358474   ⟹   XP_054214449
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0796,641,007 - 96,671,530 (-)NCBI
RefSeq Acc Id: XM_054358475   ⟹   XP_054214450
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0796,641,007 - 96,660,718 (-)NCBI
RefSeq Acc Id: XM_054358476   ⟹   XP_054214451
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0796,641,007 - 96,652,442 (-)NCBI
Protein Sequences
Protein RefSeqs NP_000296 (Get FASTA)   NCBI Sequence Viewer  
  NP_001018171 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250510 (Get FASTA)   NCBI Sequence Viewer  
  XP_016867846 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214449 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214450 (Get FASTA)   NCBI Sequence Viewer  
  XP_054214451 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC27944 (Get FASTA)   NCBI Sequence Viewer  
  AAC27945 (Get FASTA)   NCBI Sequence Viewer  
  AAC27946 (Get FASTA)   NCBI Sequence Viewer  
  AAC41995 (Get FASTA)   NCBI Sequence Viewer  
  AAC62431 (Get FASTA)   NCBI Sequence Viewer  
  AAH09728 (Get FASTA)   NCBI Sequence Viewer  
  AAH40010 (Get FASTA)   NCBI Sequence Viewer  
  AAH46160 (Get FASTA)   NCBI Sequence Viewer  
  AAO18083 (Get FASTA)   NCBI Sequence Viewer  
  BAD89420 (Get FASTA)   NCBI Sequence Viewer  
  BAF83792 (Get FASTA)   NCBI Sequence Viewer  
  BAG37646 (Get FASTA)   NCBI Sequence Viewer  
  BAG58797 (Get FASTA)   NCBI Sequence Viewer  
  BAG59238 (Get FASTA)   NCBI Sequence Viewer  
  BAG62864 (Get FASTA)   NCBI Sequence Viewer  
  EAL24131 (Get FASTA)   NCBI Sequence Viewer  
  EAW76763 (Get FASTA)   NCBI Sequence Viewer  
  EAW76764 (Get FASTA)   NCBI Sequence Viewer  
  EAW76765 (Get FASTA)   NCBI Sequence Viewer  
  EAW76766 (Get FASTA)   NCBI Sequence Viewer  
  EAW76767 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000222572
  ENSP00000222572.3
  ENSP00000404622
  ENSP00000404622.2
  ENSP00000405211.1
  ENSP00000414515.1
  ENSP00000487703.1
  ENSP00000487898.1
  ENSP00000488378.1
  ENSP00000488462.1
  ENSP00000488550.1
  ENSP00000488822.1
  ENSP00000488826.1
  ENSP00000488838.1
  ENSP00000488874.1
GenBank Protein Q15165 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001018171   ⟸   NM_001018161
- Peptide Label: isoform 2
- UniProtKB: B4DKM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000296   ⟸   NM_000305
- Peptide Label: isoform 1
- UniProtKB: Q5FBX7 (UniProtKB/Swiss-Prot),   O75856 (UniProtKB/Swiss-Prot),   O15115 (UniProtKB/Swiss-Prot),   O15114 (UniProtKB/Swiss-Prot),   B4DJD5 (UniProtKB/Swiss-Prot),   B2RCP9 (UniProtKB/Swiss-Prot),   A4D1H7 (UniProtKB/Swiss-Prot),   Q86YL0 (UniProtKB/Swiss-Prot),   Q15165 (UniProtKB/Swiss-Prot),   B4DW02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005250510   ⟸   XM_005250453
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016867846   ⟸   XM_017012357
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSP00000487703   ⟸   ENST00000478801
RefSeq Acc Id: ENSP00000488826   ⟸   ENST00000490778
RefSeq Acc Id: ENSP00000488462   ⟸   ENST00000491069
RefSeq Acc Id: ENSP00000488822   ⟸   ENST00000493290
RefSeq Acc Id: ENSP00000488550   ⟸   ENST00000469926
RefSeq Acc Id: ENSP00000414515   ⟸   ENST00000455123
RefSeq Acc Id: ENSP00000488874   ⟸   ENST00000483292
RefSeq Acc Id: ENSP00000405211   ⟸   ENST00000446142
RefSeq Acc Id: ENSP00000222572   ⟸   ENST00000222572
RefSeq Acc Id: ENSP00000404622   ⟸   ENST00000433091
RefSeq Acc Id: ENSP00000487898   ⟸   ENST00000632034
RefSeq Acc Id: ENSP00000488378   ⟸   ENST00000633192
RefSeq Acc Id: ENSP00000488838   ⟸   ENST00000633531
RefSeq Acc Id: XP_054214449   ⟸   XM_054358474
- Peptide Label: isoform X3
- UniProtKB: A0A0J9YXF2 (UniProtKB/TrEMBL),   B4DW02 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054214450   ⟸   XM_054358475
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054214451   ⟸   XM_054358476
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15165-F1-model_v2 AlphaFold Q15165 1-354 view protein structure

Promoters
RGD ID:6805508
Promoter ID:HG_KWN:58668
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000355659,   OTTHUMT00000333141,   OTTHUMT00000333142,   OTTHUMT00000333146,   OTTHUMT00000333147,   OTTHUMT00000333148,   OTTHUMT00000333149,   OTTHUMT00000333150,   OTTHUMT00000333151,   OTTHUMT00000334034,   OTTHUMT00000334085,   OTTHUMT00000334086,   UC003UNW.1,   UC010LFK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36794,901,984 - 94,902,484 (-)MPROMDB
RGD ID:6850786
Promoter ID:EP73187
Type:initiation region
Name:HS_PON2
Description:Paraoxonase 2.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 36794,902,276 - 94,902,336EPD
RGD ID:7211119
Promoter ID:EPDNEW_H11305
Type:initiation region
Name:PON2_1
Description:paraoxonase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11306  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,435,009 - 95,435,069EPDNEW
RGD ID:7211121
Promoter ID:EPDNEW_H11306
Type:initiation region
Name:PON2_2
Description:paraoxonase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11305  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38795,435,146 - 95,435,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9205 AgrOrtholog
COSMIC PON2 COSMIC
Ensembl Genes ENSG00000105854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000222572 ENTREZGENE
  ENST00000222572.8 UniProtKB/Swiss-Prot
  ENST00000433091 ENTREZGENE
  ENST00000433091.6 UniProtKB/Swiss-Prot
  ENST00000446142.5 UniProtKB/TrEMBL
  ENST00000455123.5 UniProtKB/TrEMBL
  ENST00000469926.5 UniProtKB/TrEMBL
  ENST00000478801.5 UniProtKB/TrEMBL
  ENST00000483292.5 UniProtKB/TrEMBL
  ENST00000490778.5 UniProtKB/TrEMBL
  ENST00000491069.5 UniProtKB/TrEMBL
  ENST00000493290.5 UniProtKB/TrEMBL
  ENST00000632034.1 UniProtKB/TrEMBL
  ENST00000633192.1 UniProtKB/TrEMBL
  ENST00000633531.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000105854 GTEx
HGNC ID HGNC:9205 ENTREZGENE
Human Proteome Map PON2 Human Proteome Map
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Paraoxonase2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5445 UniProtKB/Swiss-Prot
NCBI Gene 5445 ENTREZGENE
OMIM 602447 OMIM
PANTHER PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERUM PARAOXONASE/ARYLESTERASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arylesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33530 PharmGKB
PRINTS PARAOXONASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PARAOXONASE2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Calcium-dependent phosphotriesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0J9YVW3_HUMAN UniProtKB/TrEMBL
  A0A0J9YXF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A0J9YXM1_HUMAN UniProtKB/TrEMBL
  A0A0J9YXU7_HUMAN UniProtKB/TrEMBL
  A0A0J9YYF0_HUMAN UniProtKB/TrEMBL
  A0A0J9YYF3_HUMAN UniProtKB/TrEMBL
  A0A0J9YYJ1_HUMAN UniProtKB/TrEMBL
  A0A2Q2SAK4_HUMAN UniProtKB/TrEMBL
  A4D1H7 ENTREZGENE
  B2RCP9 ENTREZGENE
  B4DJD5 ENTREZGENE
  B4DKM6 ENTREZGENE, UniProtKB/TrEMBL
  B4DW02 ENTREZGENE, UniProtKB/TrEMBL
  G3XAK4_HUMAN UniProtKB/TrEMBL
  O15114 ENTREZGENE
  O15115 ENTREZGENE
  O75856 ENTREZGENE
  PON2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FBX7 ENTREZGENE
  Q6PJZ2_HUMAN UniProtKB/TrEMBL
  Q86YL0 ENTREZGENE
UniProt Secondary A4D1H7 UniProtKB/Swiss-Prot
  B2RCP9 UniProtKB/Swiss-Prot
  B4DJD5 UniProtKB/Swiss-Prot
  O15114 UniProtKB/Swiss-Prot
  O15115 UniProtKB/Swiss-Prot
  O75856 UniProtKB/Swiss-Prot
  Q5FBX7 UniProtKB/Swiss-Prot
  Q86YL0 UniProtKB/Swiss-Prot