RGD Reference Report - Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer. - Rat Genome Database

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Effects of polymorphisms identified in genome-wide association studies of never-smoking females on the prognosis of non-small cell lung cancer.

Authors: Yoo, Seung Soo  Kang, Hyo-Gyoung  Choi, Jin Eun  Do, Sook Kyung  Lee, Won Kee  Choi, Sun Ha  Lee, So Yeon  Lee, Shin Yup  Lee, Jaehee  Cha, Seung Ick  Kim, Chang Ho  Seok, Yangki  Lee, Eungbae  Kim, Moon Soo  Lee, Jong Mog  Cho, Hyun-Ju  Oh, In-Jae  Kim, Young-Chul  Cho, Sukki  Jheon, Sanghoon  Jung, Chi Young  Kim, Mi-Hyun  Lee, Min Ki  Park, Jae Yong 
Citation: Yoo SS, etal., Cancer Genet. 2017 Apr;212-213:8-12. doi: 10.1016/j.cancergen.2017.03.003. Epub 2017 Mar 20.
RGD ID: 150524292
Pubmed: PMID:28449811   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cancergen.2017.03.003   (Journal Full-text)

A number of genome-wide association studies have reported several variants that influence the risk of lung cancer in never-smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). In total, 510 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants associated with lung cancer susceptibility in never-smoking females were genotyped and their associations with survival outcome were analyzed. Among these 11 variants, TP63 rs7631358 and CSF1R rs10079250 affected survival outcomes. TP63 rs7631358 G > A was associated with a relatively worse overall survival (under a dominant model; hazard ratio = 2.31, 95% confidence interval = 1.18-4.52, P = 0.01). CSF1R rs10079250 A > G was associated with a relatively better disease-free survival (under a codominant model; hazard ratio = 0.70, 95% confidence interval = 0.53-0.93, P = 0.01). These results suggest that TP63 rs7631358 G > A and CSF1R rs10079250 A > G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung non-small cell carcinoma severityIAGP 150524292DNA:missense mutation:CDS:p.H362R (rs10079250) (human)RGD 
lung non-small cell carcinoma severityISOCSF1R (Homo sapiens)150524292; 150524292DNA:missense mutation:CDS:p.H362R (rs10079250) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Csf1r  (colony stimulating factor 1 receptor)

Genes (Mus musculus)
Csf1r  (colony stimulating factor 1 receptor)

Genes (Homo sapiens)
CSF1R  (colony stimulating factor 1 receptor)


Additional Information