RGD Reference Report - Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients. - Rat Genome Database

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Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients.

Authors: Su, Chenghao  Lin, Yong  Mao, Qianguo  Wu, Daitze  Zhu, Lina  Najera, Isabel  Garcia-Alcalde, Fernando  Niu, Jianjun 
Citation: Su C, etal., Aging (Albany NY). 2016 Nov 7;8(11):2862-2870. doi: 10.18632/aging.101097.
RGD ID: 14696831
Pubmed: PMID:27824315   (View Abstract at PubMed)
PMCID: PMC5191875   (View Article at PubMed Central)
DOI: DOI:10.18632/aging.101097   (Journal Full-text)

Mannose binding lectin (MBL) plays important role in the innate immunity of human. Mutations in the MBL2 gene can significantly change the serum level of MBL, and consequently alter the susceptibility and progression of infectious disease. However, the association between the MBL2 profile and the HBV mutation and quasispecies complexity has not yet been reported. Our approach includes the study of the MBL2 gene genotype as well as ultra-deep sequencing of the HBV viruses obtained from the plasma of 50 treatment naïve patients with chronic HBV infection. We found that the liver function was better among patients within the high MBL2 group with respect to those within the medium/low MBL2 group. Likewise, the number of mutations in the HBV X gene as well as the viral quasispecies complexity were significantly higher in medium/low MBL2 production group. Nucleotide substitution rates were also higher within the medium/low MBL2 production group in all positions described to have an influence in liver cancer development, except for A1499G. In this work we show that the MBL2 profile may have an impact on the HBV X gene mutations as well as on viral quasispecies complexity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Hepatitis B severityIAGP 14696831DNA:haplotype: :RGD 
Chronic Hepatitis B severityISOMBL2 (Homo sapiens)14696831; 14696831DNA:haplotype: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mbl2  (mannose binding lectin 2)

Genes (Mus musculus)
Mbl2  (mannose-binding lectin (protein C) 2)

Genes (Homo sapiens)
MBL2  (mannose binding lectin 2)


Additional Information