RGD Reference Report - Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. - Rat Genome Database

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Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.

Authors: Miura, Koh  Bowman, Elise D  Simon, Richard  Peng, Amy C  Robles, Ana I  Jones, Raymond T  Katagiri, Toyomasa  He, Ping  Mizukami, Hiroki  Charboneau, Lu  Kikuchi, Takefumi  Liotta, Lance A  Nakamura, Yusuke  Harris, Curtis C 
Citation: Miura K, etal., Cancer Res. 2002 Jun 1;62(11):3244-50.
RGD ID: 14696682
Pubmed: PMID:12036940   (View Abstract at PubMed)

Recent expression profile analyses revealed that lung adenocarcinomas can be divided into several subgroups with diverse pathological features. Because cellular heterogeneity of tumors can confound these analyses, we used laser capture microdissection and microarray expression analysis to characterize the molecular profiles of lung adenocarcinomas. We found 45 genes delineating smokers and nonsmokers that were located at chromosomal loci frequently altered in non-small cell lung cancers, and 27 genes, which were differentially expressed between survivors and nonsurvivors 5 years after surgery. These results are consistent with the hypothesis that the abnormal expression of genes involved in maintaining the mitotic spindle checkpoint and genomic stability, e.g., hBUB3, hZW10, and APC2, contribute to the molecular pathogenesis and tumor progression of tobacco smoke-induced adenocarcinoma of the lung.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
lung adenocarcinoma severityIEP 14696682mRNA:decreased expression:lung (human)RGD 
lung adenocarcinoma severityISOANAPC2 (Homo sapiens)14696682; 14696682mRNA:decreased expression:lung (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Anapc2  (anaphase promoting complex subunit 2)

Genes (Mus musculus)
Anapc2  (anaphase promoting complex subunit 2)

Genes (Homo sapiens)
ANAPC2  (anaphase promoting complex subunit 2)


Additional Information