RGD Reference Report - [Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma]. - Rat Genome Database

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[Genetic polymorphism of cytochrome P450 2E1 and the risk of nasopharyngeal carcinoma].

Authors: Ben Chaaben, Arij  Abaza, Hajer  Douik, Hayet  Chaouch, Leila  Ayari, Fayza  Ouni, Nesrine  Mamoghli, Tasnim  Ben Guezella, Dorra  Mejri, Rachida  Harzallah, Latifa  Guemira, Fethi 
Citation: Ben Chaaben A, etal., Bull Cancer. 2015 Dec;102(12):967-72. doi: 10.1016/j.bulcan.2015.09.013. Epub 2015 Nov 12.
RGD ID: 11061495
Pubmed: PMID:26582733   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bulcan.2015.09.013   (Journal Full-text)

Cytochrome P450 2E1 (CYP2E1) is a detoxifying enzyme that belongs to the phase I metabolism of xenobiotics. This enzyme is encoded by a highly polymorphic gene whose common polymorphism corresponds to the substitution of cytosine (C) and thymine (T) at position -1019 (rs2031920). This polymorphism has been identified in several cancers including nasopharyngeal cancer (NPC). The study involved 124 patients with nasopharyngeal carcinoma, compared with 166 healthy controls. The presence or absence of the polymorphism is determined by PCR-RFLP. The frequency comparison between the two groups is determined by the ¿(2) test. The analysis of our results showed a significant difference between the two groups regarding the mutant genotype (C2/C2) (5% vs. 0.5%, P=0.04) and has a risk factor for NPC in Tunisia (OR=8.39; CI 95% [0.99-388.1]). Also, the C2 allele was significantly associated with the group of patients than the control group (6% vs. 2%, P=0.016) and increased three times the risk of NPC in Tunisia (OR=2.99, CI 95% [1.12-8.79]). Our results confirm the results reported in other populations and emphasize the importance of the involvement of this gene in the development of detoxification of the NPC, which seems more and more strongly associated with environmental factors.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nasopharynx carcinoma  IAGP 11061495DNA:SNP: :rs2031920 (human)RGD 
nasopharynx carcinoma  ISOCYP2E1 (Homo sapiens)11061495; 11061495DNA:SNP: :rs2031920 (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyp2e1  (cytochrome P450, family 2, subfamily e, polypeptide 1)

Genes (Mus musculus)
Cyp2e1  (cytochrome P450, family 2, subfamily e, polypeptide 1)

Genes (Homo sapiens)
CYP2E1  (cytochrome P450 family 2 subfamily E member 1)


Additional Information