RGD Reference Report - Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. - Rat Genome Database

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Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury.

Authors: Le, LL  Li, XY  Meng, D  Liang, QJ  Wang, XH  Li, N  Quan, J  Xiang, M  Jiang, M  Sun, J  Chen, SF 
Citation: Le LL, etal., CNS Neurosci Ther. 2013 Dec;19(12):963-8. doi: 10.1111/cns.12152. Epub 2013 Jul 22.
RGD ID: 10755755
Pubmed: PMID:23870531   (View Abstract at PubMed)
PMCID: PMC6493422   (View Article at PubMed Central)
DOI: DOI:10.1111/cns.12152   (Journal Full-text)

AIMS: Ischemic preconditioning (IPC) has short-term benefits for stroke patients. However, if IPC protective effect is memorial and the role of the intracellular protective protein heme oxygenase-1 (HO-1) is not known. METHODS: Ischemic preconditioning and the corresponding sham control were achieved by blocking the blood flow of the left internal carotid artery for 20 min and 2 second, respectively, in rats. Both IPC and sham-operated animals were divided into three groups and treated with PBS, the HO-1 inducer hemin, and the HO-1 inhibitor Znpp. Three weeks after IPC, brain ischemia-reperfusion injury was achieved by left middle cerebral artery obstruction for 45 min followed by 24-h reperfusion. RESULTS: 2,3,5-triphenyltetrazolium chloride staining and neurological dysfunction scoring showed IPC significantly reduced brain infarct area and improved neurological function occurred 3 weeks after IPC. Hemin treatment promoted whereas ZnPP blocked the benefits of IPC. Immunohistochemical analysis and Western blotting showed that the expression of HO-1 was higher in the border zone than in the necrotic core zone. The memorial IPC protection is independent of adenosine receptor A1R and A2aR expressions. CONCLUSIONS: We found for the first time that the protective effect of IPC can be remembered to protect brain injury occurred after acute response disappear. The results indicate that interventional treatment can achieve protective effect for future cerebral injury not only through interventional treatment itself but also through the memorial and revivable IPC, eliminating the concern that temporary ischemia caused by interventional treatment may leave harmful effect in the brain.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
middle cerebral artery infarction treatmentISOHmox1 (Rattus norvegicus)10755755; 10755755 RGD 
middle cerebral artery infarction treatmentIDA 10755755 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hmox1  (heme oxygenase 1)

Genes (Mus musculus)
Hmox1  (heme oxygenase 1)

Genes (Homo sapiens)
HMOX1  (heme oxygenase 1)


Additional Information