RGD Reference Report - NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death. - Rat Genome Database

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NQDI 1, an inhibitor of ASK1 attenuates acute ischemic renal injury by modulating oxidative stress and cell death.

Authors: El Eter, E 
Citation: El Eter E Cardiovasc Hematol Agents Med Chem. 2013 Sep;11(3):179-86.
RGD ID: 10412647
Pubmed: PMID:23952292   (View Abstract at PubMed)

Apoptosis signal-regulating kinase 1 (ASK1) is among the signaling events that lead to postischemic cell death. Inhibition of ASK1 pathway protected hearts from ischemic damage. The present study evaluated the renal protective effects of NQDI 1, an inhibitor of ASK1, in an animal model of acute ischemic renal failure. Male Wistar rats were subjected to right nephrectomy and clamping of left renal pedicle for 45 min, or sham operation. The administration of NQDI 1 attenuated renal dysfunction and histological changes characteristic for renal ischemia/reperfusion injury (IRI). Apoptosis of renal tissues, as detected by TUNEL staining, was also reduced together with p53 protein expression, and renal levels of MDA and SOD with NQDI 1 administration and BCL2 was up regulated. In conclusion, inhibition of ASK1 is of therapeutic potential against acute ischemic renal injury. Its protective effects are mediated via inhibition of apoptosis and oxidative stress.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kidney Reperfusion Injury treatmentISOMap3k5 (Rattus norvegicus)10412647; 10412647 RGD 
Kidney Reperfusion Injury treatmentIMP 10412647 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Map3k5  (mitogen-activated protein kinase kinase kinase 5)

Genes (Mus musculus)
Map3k5  (mitogen-activated protein kinase kinase kinase 5)

Genes (Homo sapiens)
MAP3K5  (mitogen-activated protein kinase kinase kinase 5)


Additional Information