Ripk4 (receptor-interacting serine-threonine kinase 4) - Rat Genome Database

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Gene: Ripk4 (receptor-interacting serine-threonine kinase 4) Rattus norvegicus
Analyze
Symbol: Ripk4
Name: receptor-interacting serine-threonine kinase 4
RGD ID: 1311691
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in morphogenesis of an epithelium. Predicted to be active in cytoplasm. Orthologous to human RIPK4 (receptor interacting serine/threonine kinase 4); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304053; receptor-interacting serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,591,926 - 50,614,169 (-)NCBIGRCr8
mRatBN7.21137,122,555 - 37,144,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,122,565 - 37,144,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,822,982 - 45,845,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,494,368 - 38,516,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,654,317 - 37,676,551 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01138,251,991 - 38,274,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,251,955 - 38,274,217 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,762,121 - 41,784,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,767,796 - 37,790,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,826,563 - 37,847,572 (-)NCBI
Celera1137,007,084 - 37,029,287 (-)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21931591   PMID:22197488  


Genomics

Comparative Map Data
Ripk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,591,926 - 50,614,169 (-)NCBIGRCr8
mRatBN7.21137,122,555 - 37,144,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,122,565 - 37,144,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,822,982 - 45,845,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,494,368 - 38,516,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,654,317 - 37,676,551 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01138,251,991 - 38,274,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,251,955 - 38,274,217 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,762,121 - 41,784,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,767,796 - 37,790,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,826,563 - 37,847,572 (-)NCBI
Celera1137,007,084 - 37,029,287 (-)NCBICelera
Cytogenetic Map11q12NCBI
RIPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,739,373 - 41,767,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,739,369 - 41,767,089 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,159,533 - 43,187,212 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,032,598 - 42,060,318 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,032,597 - 42,060,318NCBI
Celera2128,309,333 - 28,337,056 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,579,429 - 28,607,166 (-)NCBIHuRef
CHM1_12142,720,210 - 42,748,089 (-)NCBICHM1_1
T2T-CHM13v2.02140,129,762 - 40,157,439 (-)NCBIT2T-CHM13v2.0
Ripk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,543,133 - 97,564,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,543,133 - 97,564,987 (-)EnsemblGRCm39 Ensembl
GRCm381697,741,933 - 97,763,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,741,933 - 97,763,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,963,549 - 97,985,362 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,896,858 - 97,918,671 (-)NCBIMGSCv36mm8
Celera1698,801,182 - 98,822,963 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.63NCBI
Ripk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,728,634 - 39,748,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,728,645 - 39,748,752 (+)NCBIChiLan1.0ChiLan1.0
RIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,809,930 - 37,838,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,664,039 - 32,692,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,062,975 - 28,091,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,389,654 - 41,417,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,389,654 - 41,417,472 (-)Ensemblpanpan1.1panPan2
RIPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,168,172 - 36,196,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,169,530 - 36,196,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,320,818 - 35,349,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,685,866 - 35,714,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,685,874 - 35,713,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,579,728 - 35,607,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,559,337 - 35,587,482 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,053,717 - 36,081,870 (-)NCBIUU_Cfam_GSD_1.0
Ripk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,429,038 - 35,450,299 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,017,518 - 2,039,108 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,017,519 - 2,038,777 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,127,244 - 205,153,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,127,239 - 205,153,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213215,452,677 - 215,478,450 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,627,307 - 85,654,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,627,073 - 85,653,927 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,482,906 - 13,509,670 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,461,900 - 28,481,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,461,948 - 28,481,721 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ripk4
61 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000002206
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat

Markers in Region
G67859  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21137,134,970 - 37,135,390 (+)MAPPERmRatBN7.2
Rnor_6.01138,264,406 - 38,264,825NCBIRnor6.0
Rnor_5.01141,774,570 - 41,774,989UniSTSRnor5.0
RGSC_v3.41137,780,201 - 37,780,620UniSTSRGSC3.4
Celera1137,019,459 - 37,019,878UniSTS
Cytogenetic Map11q12UniSTS
RH133662  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21137,122,704 - 37,122,892 (+)MAPPERmRatBN7.2
Rnor_6.01138,252,141 - 38,252,328NCBIRnor6.0
Rnor_5.01141,762,271 - 41,762,458UniSTSRnor5.0
RGSC_v3.41137,767,936 - 37,768,123UniSTSRGSC3.4
Celera1137,007,224 - 37,007,411UniSTS
RH 3.4 Map11280.7UniSTS
Cytogenetic Map11q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 5 5 33 8 2
Low 1 2 47 36 8 36 44 2 32 9
Below cutoff 4 5 11 5 5 28 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002206   ⟹   ENSRNOP00000002206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1137,122,565 - 37,144,799 (-)Ensembl
Rnor_6.0 Ensembl1138,251,955 - 38,274,217 (-)Ensembl
RefSeq Acc Id: NM_001107103   ⟹   NP_001100573
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,591,936 - 50,614,169 (-)NCBI
mRatBN7.21137,122,565 - 37,144,799 (-)NCBI
Rnor_6.01138,252,001 - 38,274,234 (-)NCBI
Rnor_5.01141,762,121 - 41,784,396 (-)NCBI
RGSC_v3.41137,767,796 - 37,790,029 (-)RGD
Celera1137,007,084 - 37,029,287 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598012   ⟹   XP_017453501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,591,926 - 50,613,907 (-)NCBI
mRatBN7.21137,122,555 - 37,144,537 (-)NCBI
Rnor_6.01138,251,991 - 38,273,982 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001100573 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453501 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM10976 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002206
  ENSRNOP00000002206.2
Reference Protein Sequences
RefSeq Acc Id: NP_001100573   ⟸   NM_001107103
- UniProtKB: A6IQH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453501   ⟸   XM_017598012
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000002206   ⟸   ENSRNOT00000002206
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAK5-F1-model_v2 AlphaFold D4AAK5 1-786 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698095
Promoter ID:EPDNEW_R8620
Type:initiation region
Name:Ripk4_1
Description:receptor-interacting serine-threonine kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01138,274,210 - 38,274,270EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311691 AgrOrtholog
BioCyc Gene G2FUF-21676 BioCyc
Ensembl Genes ENSRNOG00000001618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002206 ENTREZGENE
  ENSRNOT00000002206.6 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:304053 UniProtKB/TrEMBL
NCBI Gene 304053 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 4 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Ripk4 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001618 RatGTEx
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A6IQH3 ENTREZGENE, UniProtKB/TrEMBL
  D4AAK5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ripk4  receptor-interacting serine-threonine kinase 4   Ripk4_predicted  receptor-interacting serine-threonine kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ripk4_predicted  receptor-interacting serine-threonine kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED