RIPK4 (receptor interacting serine/threonine kinase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: RIPK4 (receptor interacting serine/threonine kinase 4) Chlorocebus sabaeus
Analyze
Symbol: RIPK4
Name: receptor interacting serine/threonine kinase 4
RGD ID: 18532820
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN morphogenesis of an epithelium (inferred); ASSOCIATED WITH Bartsocas-Papas Syndrome 1 (ortholog); cataract 9 multiple types (ortholog); Curly Hair-Ankyloblepharon-Nail Dysplasia Syndrome (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-interacting serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,627,307 - 85,654,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,627,073 - 85,653,927 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,482,906 - 13,509,670 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
RIPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,627,307 - 85,654,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,627,073 - 85,653,927 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,482,906 - 13,509,670 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RIPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,739,373 - 41,767,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,739,369 - 41,767,089 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,159,533 - 43,187,212 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,032,598 - 42,060,318 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,032,597 - 42,060,318NCBI
Celera2128,309,333 - 28,337,056 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,579,429 - 28,607,166 (-)NCBIHuRef
CHM1_12142,720,210 - 42,748,089 (-)NCBICHM1_1
T2T-CHM13v2.02140,129,762 - 40,157,439 (-)NCBIT2T-CHM13v2.0
Ripk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,543,133 - 97,564,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,543,133 - 97,564,987 (-)EnsemblGRCm39 Ensembl
GRCm381697,741,933 - 97,763,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,741,933 - 97,763,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,963,549 - 97,985,362 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,896,858 - 97,918,671 (-)NCBIMGSCv36mm8
Celera1698,801,182 - 98,822,963 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.63NCBI
Ripk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,591,926 - 50,614,169 (-)NCBIGRCr8
mRatBN7.21137,122,555 - 37,144,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,122,565 - 37,144,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,822,982 - 45,845,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,494,368 - 38,516,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,654,317 - 37,676,551 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01138,251,991 - 38,274,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,251,955 - 38,274,217 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,762,121 - 41,784,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,767,796 - 37,790,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,826,563 - 37,847,572 (-)NCBI
Celera1137,007,084 - 37,029,287 (-)NCBICelera
Cytogenetic Map11q12NCBI
Ripk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,728,634 - 39,748,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,728,645 - 39,748,752 (+)NCBIChiLan1.0ChiLan1.0
RIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,809,930 - 37,838,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,664,039 - 32,692,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,062,975 - 28,091,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,389,654 - 41,417,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,389,654 - 41,417,472 (-)Ensemblpanpan1.1panPan2
RIPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,168,172 - 36,196,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,169,530 - 36,196,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,320,818 - 35,349,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,685,866 - 35,714,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,685,874 - 35,713,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,579,728 - 35,607,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,559,337 - 35,587,482 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,053,717 - 36,081,870 (-)NCBIUU_Cfam_GSD_1.0
Ripk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,429,038 - 35,450,299 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,017,518 - 2,039,108 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,017,519 - 2,038,777 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,127,244 - 205,153,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,127,239 - 205,153,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213215,452,677 - 215,478,450 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ripk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,461,900 - 28,481,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,461,948 - 28,481,721 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 16 16
Low 9 12 4
Below cutoff 9 6 21

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007968795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000006274   ⟹   ENSCSAP00000004481
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl285,627,073 - 85,653,927 (-)Ensembl
RefSeq Acc Id: XM_007968795   ⟹   XP_007966986
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1285,627,307 - 85,654,079 (-)NCBI
Vero_WHO_p1.0NW_02366605413,482,906 - 13,509,670 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007966986 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000004481
  ENSCSAP00000004481.1
Reference Protein Sequences
RefSeq Acc Id: XP_007966986   ⟸   XM_007968795
- UniProtKB: A0A0D9R792 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000004481   ⟸   ENSCSAT00000006274


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008221 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006274.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene RIPK4 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 4 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9R792 ENTREZGENE, UniProtKB/TrEMBL