RIPK4 (receptor interacting serine/threonine kinase 4) - Rat Genome Database

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Gene: RIPK4 (receptor interacting serine/threonine kinase 4) Canis lupus familiaris
Analyze
Symbol: RIPK4
Name: receptor interacting serine/threonine kinase 4
RGD ID: 12145990
Description: ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN morphogenesis of an epithelium (inferred); ASSOCIATED WITH Bartsocas-Papas Syndrome 1 (ortholog); cataract 9 multiple types (ortholog); Curly Hair-Ankyloblepharon-Nail Dysplasia Syndrome (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-interacting serine/threonine-protein kinase 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,168,172 - 36,196,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,169,530 - 36,196,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,320,818 - 35,349,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,685,866 - 35,714,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,685,874 - 35,713,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,579,728 - 35,607,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,559,337 - 35,587,482 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,053,717 - 36,081,870 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
RIPK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13136,168,172 - 36,196,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3136,169,530 - 36,196,600 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3135,320,818 - 35,349,150 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03135,685,866 - 35,714,030 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3135,685,874 - 35,713,505 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13135,579,728 - 35,607,542 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03135,559,337 - 35,587,482 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03136,053,717 - 36,081,870 (-)NCBIUU_Cfam_GSD_1.0
RIPK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382141,739,373 - 41,767,052 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2141,739,369 - 41,767,089 (-)EnsemblGRCh38hg38GRCh38
GRCh372143,159,533 - 43,187,212 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362142,032,598 - 42,060,318 (-)NCBINCBI36Build 36hg18NCBI36
Build 342142,032,597 - 42,060,318NCBI
Celera2128,309,333 - 28,337,056 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2128,579,429 - 28,607,166 (-)NCBIHuRef
CHM1_12142,720,210 - 42,748,089 (-)NCBICHM1_1
T2T-CHM13v2.02140,129,762 - 40,157,439 (-)NCBIT2T-CHM13v2.0
Ripk4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391697,543,133 - 97,564,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1697,543,133 - 97,564,987 (-)EnsemblGRCm39 Ensembl
GRCm381697,741,933 - 97,763,779 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1697,741,933 - 97,763,787 (-)EnsemblGRCm38mm10GRCm38
MGSCv371697,963,549 - 97,985,362 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361697,896,858 - 97,918,671 (-)NCBIMGSCv36mm8
Celera1698,801,182 - 98,822,963 (-)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1657.63NCBI
Ripk4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,591,926 - 50,614,169 (-)NCBIGRCr8
mRatBN7.21137,122,555 - 37,144,799 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1137,122,565 - 37,144,799 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1145,822,982 - 45,845,215 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01138,494,368 - 38,516,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01137,654,317 - 37,676,551 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01138,251,991 - 38,274,234 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1138,251,955 - 38,274,217 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01141,762,121 - 41,784,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,767,796 - 37,790,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,826,563 - 37,847,572 (-)NCBI
Celera1137,007,084 - 37,029,287 (-)NCBICelera
Cytogenetic Map11q12NCBI
Ripk4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540739,728,634 - 39,748,791 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540739,728,645 - 39,748,752 (+)NCBIChiLan1.0ChiLan1.0
RIPK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22237,809,930 - 37,838,106 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12132,664,039 - 32,692,016 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02128,062,975 - 28,091,323 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12141,389,654 - 41,417,472 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2141,389,654 - 41,417,472 (-)Ensemblpanpan1.1panPan2
Ripk4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497135,429,038 - 35,450,299 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365002,017,518 - 2,039,108 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365002,017,519 - 2,038,777 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RIPK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13205,127,244 - 205,153,005 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113205,127,239 - 205,153,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213215,452,677 - 215,478,450 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RIPK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1285,627,307 - 85,654,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl285,627,073 - 85,653,927 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605413,482,906 - 13,509,670 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ripk4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474528,461,900 - 28,481,813 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474528,461,948 - 28,481,721 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RIPK4
711 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6 6 6 5
Low 5 11 6 2 6 4 5 1
Below cutoff 5 4 4 3 2 8 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016214   ⟹   ENSCAFP00000014998
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3136,169,530 - 36,196,600 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845053606   ⟹   ENSCAFP00845042123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3135,685,874 - 35,713,505 (-)Ensembl
RefSeq Acc Id: XM_038443564   ⟹   XP_038299492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03135,685,866 - 35,713,473 (-)NCBI
RefSeq Acc Id: XM_038443565   ⟹   XP_038299493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03135,685,866 - 35,714,030 (-)NCBI
RefSeq Acc Id: XM_038461853   ⟹   XP_038317781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3135,320,818 - 35,348,642 (-)NCBI
RefSeq Acc Id: XM_038461854   ⟹   XP_038317782
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha3135,320,818 - 35,349,150 (-)NCBI
RefSeq Acc Id: XM_038517972   ⟹   XP_038373900
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.13135,579,728 - 35,607,542 (-)NCBI
RefSeq Acc Id: XM_038581543   ⟹   XP_038437471
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03136,053,717 - 36,081,315 (-)NCBI
RefSeq Acc Id: XM_038581544   ⟹   XP_038437472
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.03136,053,717 - 36,081,870 (-)NCBI
RefSeq Acc Id: XM_038645930   ⟹   XP_038501858
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03135,559,337 - 35,586,934 (-)NCBI
RefSeq Acc Id: XM_038645931   ⟹   XP_038501859
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.03135,559,337 - 35,587,482 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000014998   ⟸   ENSCAFT00000016214
RefSeq Acc Id: XP_038373900   ⟸   XM_038517972
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038501859   ⟸   XM_038645931
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038501858   ⟸   XM_038645930
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038299493   ⟸   XM_038443565
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038299492   ⟸   XM_038443564
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KV33 (UniProtKB/TrEMBL),   A0A8I3Q8Y1 (UniProtKB/TrEMBL),   A0A8C0P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317782   ⟸   XM_038461854
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317781   ⟸   XM_038461853
- Peptide Label: isoform X1
- UniProtKB: A0A8P0NC87 (UniProtKB/TrEMBL),   A0A8C0P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437472   ⟸   XM_038581544
- Peptide Label: isoform X2
- UniProtKB: A0A8C0P4T7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038437471   ⟸   XM_038581543
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KV33 (UniProtKB/TrEMBL),   A0A8C0P4T7 (UniProtKB/TrEMBL),   A0A8I3Q8Y1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845042123   ⟸   ENSCAFT00845053606
Protein Domains
Protein kinase

Promoters
RGD ID:13688644
Promoter ID:EPDNEW_C6712
Type:single initiation site
Name:RIPK4_1
Description:receptor interacting serine/threonine kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13136,196,062 - 36,196,122EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010213 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023021 UniProtKB/TrEMBL
  ENSCAFG00845030222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016214.5 UniProtKB/TrEMBL
  ENSCAFT00030042317.1 UniProtKB/TrEMBL
  ENSCAFT00845053606 ENTREZGENE
  ENSCAFT00845053606.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene RIPK4 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  RECEPTOR-INTERACTING SERINE_THREONINE-PROTEIN KINASE 4 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0KV33 ENTREZGENE
  A0A8C0P4T7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q8Y1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NC87 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45596 ENTREZGENE