Ppp1cb (protein phosphatase 1 catalytic subunit beta) - Rat Genome Database

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Gene: Ppp1cb (protein phosphatase 1 catalytic subunit beta) Rattus norvegicus
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Symbol: Ppp1cb
Name: protein phosphatase 1 catalytic subunit beta
RGD ID: 3376
Description: Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation; regulation of glycogen biosynthetic process; and regulation of glycogen catabolic process. Located in glycogen granule. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: PP-1B; PP1B; PP1beta; protein phosphatase 1, catalytic subunit, beta isoform; protein phosphatase 1, catalytic subunit, beta isozyme; protein phosphatase-1a; serine/threonine-protein phosphatase PP1-beta catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ppp1cb-ps1   Ppp1cb-ps7  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8629,681,099 - 29,712,835 (-)NCBIGRCr8
mRatBN7.2623,958,813 - 23,992,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl623,960,998 - 23,992,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,260,597 - 24,292,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,576,477 - 24,608,213 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,065,465 - 24,097,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0623,548,507 - 23,581,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,416,540 - 33,448,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,067,544 - 24,099,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,070,497 - 24,102,233 (-)NCBI
Celera623,460,146 - 23,491,883 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ppp1cbRatDandy-Walker syndrome  ISOPPP1CB (Homo sapiens)8554872ClinVar Annotator: match by term: Dandy-Walker syndromeClinVarPMID:25741868 more ...
Ppp1cbRatgenetic disease  ISOPPP1CB (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Ppp1cbRatNoonan syndrome  ISOPPP1CB (Homo sapiens)8554872ClinVar Annotator: match by term: Noonan syndromeClinVarPMID:25741868 more ...
Ppp1cbRatNoonan syndrome-like disorder with loose anagen hair 2  ISOPPP1CB (Homo sapiens)8554872ClinVar more ...ClinVarPMID:24033266 more ...
Ppp1cbRatRASopathy  ISOPPP1CB (Homo sapiens)8554872ClinVar Annotator: match by term: RASopathyClinVarPMID:25741868 more ...
Ppp1cbRatTatton-Brown-Rahman syndrome  ISOPPP1CB (Homo sapiens)8554872ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndromeClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Ppp1cbRatNoonan syndrome-like disorder with loose anagen hair 2  ISOPPP1CB (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
Ppp1cbRat1,2-dimethylhydrazine multiple interactionsISOPpp1cb (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PPP1CB mRNACTDPMID:22206623
Ppp1cbRat1,2-dimethylhydrazine decreases expressionISOPpp1cb (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PPP1CB mRNACTDPMID:22206623
Ppp1cbRat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOPpp1cb (Mus musculus)64804642 more ...CTDPMID:31388691
Ppp1cbRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPpp1cb (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PPP1CB mRNACTDPMID:21570461
Ppp1cbRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PPP1CB mRNACTDPMID:32109520 more ...
Ppp1cbRat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Ppp1cbRat2,6-dimethoxyphenol multiple interactionsISOPPP1CB (Homo sapiens)6480464[pyrogallol 1 and 3-dimethyl ether co-treated with Furaldehyde] results in decreased expression of and affects the localization of PPP1CB proteinCTDPMID:38598786
Ppp1cbRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOPPP1CB (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PPP1CB mRNACTDPMID:28628672
Ppp1cbRat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of PPP1CB mRNACTDPMID:19162173
Ppp1cbRat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of PPP1CB mRNACTDPMID:33565098
Ppp1cbRat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of PPP1CB mRNACTDPMID:36041667
Ppp1cbRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of PPP1CB mRNACTDPMID:24780913
Ppp1cbRat7,12-dimethyltetraphene affects expressionISOPpp1cb (Mus musculus)64804649 more ...CTDPMID:21785161
Ppp1cbRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of PPP1CB mRNACTDPMID:31881176
Ppp1cbRatacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of PPP1CB mRNACTDPMID:28959563
Ppp1cbRatactinomycin D multiple interactionsISOPPP1CB (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of PPP1CB proteinCTDPMID:38460933
Ppp1cbRatall-trans-retinoic acid decreases expressionISOPPP1CB (Homo sapiens)6480464Tretinoin results in decreased expression of PPP1CB mRNACTDPMID:15498508
Ppp1cbRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PPP1CB mRNACTDPMID:16483693
Ppp1cbRatampicillin multiple interactionsEXP 6480464[Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in increased expression of PPP1CB proteinCTDPMID:30545405
Ppp1cbRataristolochic acid A decreases expressionISOPPP1CB (Homo sapiens)6480464aristolochic acid I results in decreased expression of PPP1CB mRNACTDPMID:33212167

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Biological Process
1 to 20 of 22 rows

  
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Original Reference(s)
Ppp1cbRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Ppp1cbRatchromatin remodeling involved_inIEAGO:01407911600115GO_REF:0000108GOCGO_REF:0000108
Ppp1cbRatcircadian regulation of gene expression involved_inISSUniProtKB:P621411600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatcircadian regulation of gene expression involved_inIBAMGI:104871 and PANTHER:PTN0001858071600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppp1cbRatcircadian regulation of gene expression involved_inISOPpp1cb (Mus musculus)1624291 PMID:21930935RGDPMID:21930935
Ppp1cbRatentrainment of circadian clock by photoperiod involved_inISSUniProtKB:P621411600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatentrainment of circadian clock by photoperiod involved_inISOPpp1cb (Mus musculus)1624291 PMID:21712997RGDPMID:21712997
Ppp1cbRatglycogen metabolic process involved_inIEAUniProtKB-KW:KW-03211600115GO_REF:0000043UniProtGO_REF:0000043
Ppp1cbRatprotein dephosphorylation  IDA 2304267 RGD 
Ppp1cbRatprotein dephosphorylation involved_inISOPpp1cb (Mus musculus)1624291 PMID:21930935RGDPMID:21930935
Ppp1cbRatprotein dephosphorylation acts_upstream_of_or_withinISOPpp1cb (Mus musculus)1624291 PMID:14640981RGDPMID:14640981
Ppp1cbRatregulation of cell adhesion involved_inISSUniProtKB:P621401600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatregulation of cell adhesion involved_inISOPPP1CB (Homo sapiens)1624291 PMID:20354225RGDPMID:20354225
Ppp1cbRatregulation of circadian rhythm involved_inISOPPP1CB (Homo sapiens)1624291 PMID:21712997RGDPMID:21712997
Ppp1cbRatregulation of circadian rhythm involved_inIBAMGI:104871 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppp1cbRatregulation of circadian rhythm involved_inISSUniProtKB:P621401600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatregulation of circadian rhythm involved_inISSUniProtKB:P621411600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatregulation of circadian rhythm involved_inISOPpp1cb (Mus musculus)1624291 PMID:21712997 and PMID:21930935RGDPMID:21712997 and PMID:21930935
Ppp1cbRatregulation of glycogen biosynthetic process  IDA 2304267 RGD 
Ppp1cbRatregulation of glycogen catabolic process  IDA 2304267 RGD 
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Cellular Component
1 to 14 of 14 rows

  
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Original Reference(s)
Ppp1cbRatchromosome, telomeric region located_inISOPPP1CB (Homo sapiens)1624291 PMID:24270157RGDPMID:24270157
Ppp1cbRatcytoplasm is_active_inIBAFB:FBgn0000711 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppp1cbRatcytoplasm located_inISOPpp1cb (Mus musculus)1624291 PMID:21471512RGDPMID:21471512
Ppp1cbRatcytosol located_inTAS 1600115Reactome:R-NUL-421062ReactomeReactome:R-NUL-421062
Ppp1cbRatcytosol located_inISOPPP1CB (Homo sapiens)1624291 RGDGO_REF:0000052
Ppp1cbRatcytosol located_inTAS 1600115Reactome:R-RNO-163609ReactomeReactome:R-RNO-163609
Ppp1cbRatglycogen granule  IDA 2304267 RGD 
Ppp1cbRatnucleolus located_inIEAUniProtKB-SubCell:SL-01881600115GO_REF:0000044UniProtGO_REF:0000044
Ppp1cbRatnucleoplasm located_inIEAUniProtKB-SubCell:SL-01901600115GO_REF:0000044UniProtGO_REF:0000044
Ppp1cbRatnucleoplasm located_inISOPPP1CB (Homo sapiens)1624291 RGDGO_REF:0000052
Ppp1cbRatnucleus is_active_inIBACGD:CAL0000191628 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ppp1cbRatprotein phosphatase type 1 complex  IDA 2304267 RGD 
Ppp1cbRatPTW/PP1 phosphatase complex part_ofISSUniProtKB:P621401600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatPTW/PP1 phosphatase complex part_ofISOPPP1CB (Homo sapiens)1624291 PMID:20354225 and PMID:20516061RGDPMID:20354225 and PMID:20516061
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Molecular Function
1 to 20 of 26 rows

  
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Original Reference(s)
Ppp1cbRatcalmodulin-dependent protein phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Ppp1cbRathistone H2AXS140 phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Ppp1cbRatMAP kinase serine/threonine phosphatase activity enablesIEAEC:3.1.3.161600115GO_REF:0000003UniProtGO_REF:0000003
Ppp1cbRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Ppp1cbRatmyosin phosphatase activity enablesISSUniProtKB:P621431600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatmyosin-light-chain-phosphatase activity enablesISSUniProtKB:P621401600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatmyosin-light-chain-phosphatase activity enablesISOPPP1CB (Homo sapiens)1624291 PMID:20354225RGDPMID:20354225
Ppp1cbRatphosphatase activity enablesISSUniProtKB:P621411600115GO_REF:0000024UniProtGO_REF:0000024
Ppp1cbRatphosphatase activity enablesISOPpp1cb (Mus musculus)1624291 PMID:21930935RGDPMID:21930935
Ppp1cbRatphosphoprotein phosphatase activity  IDA 2304267 RGD 
Ppp1cbRatphosphoprotein phosphatase activity enablesIEAUniProtKB-KW:KW-09041600115GO_REF:0000043UniProtGO_REF:0000043
Ppp1cbRatphosphoprotein phosphatase activity enablesIEAARBA:ARBA000276511600115GO_REF:0000117UniProtGO_REF:0000117
Ppp1cbRatprotein binding  IPIPpp1r12a (Rattus norvegicus) and Pawr (Rattus norvegicus)9835415 RGD 
Ppp1cbRatprotein binding enablesISOPpp1cb (Mus musculus)1624291PR:Q9CW07 PMID:21471512RGDPMID:21471512
Ppp1cbRatprotein binding enablesISOPPP1CB (Homo sapiens)1624291UniProtKB:A0A0S2Z4Q8 more ...RGDPMID:11067852 more ...
Ppp1cbRatprotein binding enablesIPIUniProtKB:O358678554111PMID:18216290IntAct 
Ppp1cbRatprotein binding enablesIPIUniProtKB:P098952316860PMID:7649987IntAct 
Ppp1cbRatprotein kinase binding enablesISOPPP1CB (Homo sapiens)1624291UniProtKB:O60285 and PMID:20354225RGDPMID:20354225
Ppp1cbRatprotein serine/threonine phosphatase activity enablesTAS 1600115Reactome:R-RNO-163609ReactomeReactome:R-RNO-163609
Ppp1cbRatprotein serine/threonine phosphatase activity enablesISOPpp1cb (Mus musculus)1624291 PMID:14640981RGDPMID:14640981
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
Ppp1cbRatinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Ppp1cbRatlong term potentiation  IEA 6907045 KEGGrno:04720

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#
Reference Title
Reference Citation
1. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
2. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
3. Differential expression of protein phosphatase 1 isoforms in mammalian brain. da Cruz e Silva EF, etal., J Neurosci 1995 May;15(5 Pt 1):3375-89.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. AMP-activated protein kinase: also regulated by ADP? Hardie DG, etal., Trends Biochem Sci. 2011 Sep;36(9):470-7. doi: 10.1016/j.tibs.2011.06.004. Epub 2011 Jul 23.
6. Interaction of the ribosomal protein, L5, with protein phosphatase type 1. Hirano K, etal., J Biol Chem. 1995 Aug 25;270(34):19786-90.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. Moorhead G, etal., FEBS Lett. 1995 Apr 3;362(2):101-5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Par-4: a new activator of myosin phosphatase. Vetterkind S, etal., Mol Biol Cell. 2010 Apr 1;21(7):1214-24. doi: 10.1091/mbc.E09-08-0711. Epub 2010 Feb 3.
17. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
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PMID:1653777   PMID:2174876   PMID:9755872   PMID:11162467   PMID:12065664   PMID:14640981   PMID:15247246   PMID:15489334   PMID:19199708   PMID:20124353   PMID:20354225   PMID:20516061  
PMID:21423176   PMID:21471512   PMID:21630459   PMID:21700703   PMID:21712997   PMID:21930935   PMID:24270157   PMID:25931508   PMID:26702053  



Ppp1cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8629,681,099 - 29,712,835 (-)NCBIGRCr8
mRatBN7.2623,958,813 - 23,992,841 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl623,960,998 - 23,992,824 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx624,260,597 - 24,292,337 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0624,576,477 - 24,608,213 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0624,065,465 - 24,097,720 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0623,548,507 - 23,581,136 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0633,416,540 - 33,448,276 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,067,544 - 24,099,280 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1624,070,497 - 24,102,233 (-)NCBI
Celera623,460,146 - 23,491,883 (-)NCBICelera
Cytogenetic Map6q14NCBI
PPP1CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38228,751,604 - 28,802,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl228,751,640 - 28,802,940 (+)EnsemblGRCh38hg38GRCh38
GRCh37228,974,470 - 29,025,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36228,828,118 - 28,879,310 (+)NCBINCBI36Build 36hg18NCBI36
Build 34228,886,264 - 28,937,456NCBI
Celera228,820,144 - 28,871,300 (+)NCBICelera
Cytogenetic Map2p23.2NCBI
HuRef228,716,532 - 28,767,764 (+)NCBIHuRef
CHM1_1228,904,700 - 28,955,863 (+)NCBICHM1_1
T2T-CHM13v2.0228,795,220 - 28,846,552 (+)NCBIT2T-CHM13v2.0
Ppp1cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39532,616,192 - 32,651,057 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl532,616,187 - 32,674,777 (+)EnsemblGRCm39 Ensembl
GRCm38532,458,848 - 32,493,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl532,458,843 - 32,517,433 (+)EnsemblGRCm38mm10GRCm38
MGSCv37532,761,343 - 32,796,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36532,735,841 - 32,769,335 (+)NCBIMGSCv36mm8
Celera529,932,959 - 29,967,634 (+)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.33NCBI
Ppp1cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546910,662,032 - 10,682,398 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546910,657,029 - 10,682,398 (+)NCBIChiLan1.0ChiLan1.0
PPP1CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21297,705,718 - 97,757,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A97,709,065 - 97,761,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A28,758,176 - 28,809,561 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A28,863,650 - 28,889,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A28,862,083 - 28,889,401 (+)Ensemblpanpan1.1panPan2
PPP1CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11722,680,691 - 22,699,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1722,679,783 - 22,699,999 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1722,457,238 - 22,494,559 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01723,225,044 - 23,264,565 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1723,225,011 - 23,268,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11722,524,746 - 22,562,152 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01722,577,001 - 22,614,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01722,693,483 - 22,730,878 (+)NCBIUU_Cfam_GSD_1.0
Ppp1cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629266,837,482 - 66,858,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364933,981,370 - 4,002,667 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364933,981,364 - 4,002,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3110,437,688 - 110,474,891 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13110,437,681 - 110,474,896 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23117,257,014 - 117,275,122 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1CB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11478,802,295 - 78,852,683 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1478,804,548 - 78,852,682 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604533,280,709 - 33,332,417 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1cb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473810,689,152 - 10,730,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473810,689,395 - 10,730,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ppp1cb
129 total Variants

Predicted Target Of
Summary Value
Count of predictions:684
Count of miRNA genes:294
Interacting mature miRNAs:365
Transcripts:ENSRNOT00000006190
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61753252124011952Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat

1 to 10 of 34 rows
RH139638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,991,569 - 23,991,761 (+)MAPPERmRatBN7.2
Rnor_6.0623,579,887 - 23,580,078NCBIRnor6.0
Rnor_5.0633,447,111 - 33,447,302UniSTSRnor5.0
RGSC_v3.4624,098,115 - 24,098,306UniSTSRGSC3.4
Celera623,490,718 - 23,490,909UniSTS
Cytogenetic Map6q13UniSTS
RH140505  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2623,991,661 - 23,991,752 (+)MAPPERmRatBN7.2
Rnor_6.0623,579,979 - 23,580,069NCBIRnor6.0
Rnor_5.0633,447,203 - 33,447,293UniSTSRnor5.0
RGSC_v3.4624,098,207 - 24,098,297UniSTSRGSC3.4
Celera623,490,810 - 23,490,900UniSTS
Cytogenetic Map6q13UniSTS
AA901261  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6q13UniSTS
Ppp1cb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,356,391 - 68,356,761 (+)MAPPERmRatBN7.2
Rnor_6.0171,924,104 - 71,924,473NCBIRnor6.0
Rnor_5.0173,311,615 - 73,311,984UniSTSRnor5.0
RGSC_v3.4168,210,694 - 68,211,063UniSTSRGSC3.4
RGSC_v3.4167,082,822 - 67,083,191UniSTSRGSC3.4
Celera168,734,949 - 68,735,318UniSTS
Cytogenetic Map6q13UniSTS
Ppp1cb  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,355,837 - 68,356,274 (+)MAPPERmRatBN7.2
mRatBN7.21922,982,218 - 22,982,680 (+)MAPPERmRatBN7.2
Rnor_6.0171,923,550 - 71,923,986NCBIRnor6.0
Rnor_6.01929,370,983 - 29,371,444NCBIRnor6.0
Rnor_5.01940,279,142 - 40,279,603UniSTSRnor5.0
Rnor_5.0173,311,061 - 73,311,497UniSTSRnor5.0
Cytogenetic Map6q13UniSTS
Cytogenetic Map19q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006190   ⟹   ENSRNOP00000006190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,960,999 - 23,992,824 (-)Ensembl
Rnor_6.0 Ensembl623,549,317 - 23,581,052 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099315   ⟹   ENSRNOP00000076771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,965,641 - 23,983,570 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102151   ⟹   ENSRNOP00000086316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,962,766 - 23,992,471 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119348   ⟹   ENSRNOP00000091459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl623,960,998 - 23,983,570 (-)Ensembl
RefSeq Acc Id: NM_013065   ⟹   NP_037197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,681,099 - 29,712,835 (-)NCBI
mRatBN7.2623,960,998 - 23,992,735 (-)NCBI
Rnor_6.0623,549,316 - 23,581,052 (-)NCBI
Rnor_5.0633,416,540 - 33,448,276 (-)NCBI
RGSC_v3.4624,067,544 - 24,099,280 (-)RGD
Celera623,460,146 - 23,491,883 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111812   ⟹   XP_038967740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8629,681,099 - 29,712,655 (-)NCBI
mRatBN7.2623,958,813 - 23,992,770 (-)NCBI
RefSeq Acc Id: NP_037197   ⟸   NM_013065
- UniProtKB: P62142 (UniProtKB/Swiss-Prot),   A6HA24 (UniProtKB/TrEMBL),   A0A8I6ABP0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006190   ⟸   ENSRNOT00000006190
RefSeq Acc Id: XP_038967740   ⟸   XM_039111812
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000091459   ⟸   ENSRNOT00000119348
Ensembl Acc Id: ENSRNOP00000076771   ⟸   ENSRNOT00000099315
Name Modeler Protein Id AA Range Protein Structure
AF-P62142-F1-model_v2 AlphaFold P62142 1-327 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694419
Promoter ID:EPDNEW_R4944
Type:multiple initiation site
Name:Ppp1cb_1
Description:protein phosphatase 1 catalytic subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0623,581,000 - 23,581,060EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38379 BioCyc
Ensembl Genes ENSRNOG00000004612 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006190.5 UniProtKB/Swiss-Prot
  ENSRNOT00000099315.1 UniProtKB/TrEMBL
  ENSRNOT00000102151.1 UniProtKB/TrEMBL
  ENSRNOT00000119348.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623630 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_catalytic_subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25594 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72523 IMAGE-MGC_LOAD
NCBI Gene 25594 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT-RELATED UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN PHOSPHATASE PP1-BETA CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STPPase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PPP1CB RGD
PhenoGen Ppp1cb PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004612 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZJA1_RAT UniProtKB/TrEMBL
  A0A8I6A5W1_RAT UniProtKB/TrEMBL
  A0A8I6ABP0 ENTREZGENE, UniProtKB/TrEMBL
  A6HA24 ENTREZGENE, UniProtKB/TrEMBL
  P62142 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P37140 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp1cb  protein phosphatase 1 catalytic subunit beta  Ppp1cb  protein phosphatase 1, catalytic subunit, beta isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ppp1cb  protein phosphatase 1, catalytic subunit, beta isozyme  Ppp1cb  protein phosphatase 1, catalytic subunit, beta isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppp1cb  Protein phosphatase 1, catalytic subunit, beta isoform      Symbol and Name status set to approved 70586 APPROVED