Apbb3 (amyloid beta precursor protein binding family B member 3) - Rat Genome Database

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Gene: Apbb3 (amyloid beta precursor protein binding family B member 3) Chinchilla lanigera
Analyze
Symbol: Apbb3
Name: amyloid beta precursor protein binding family B member 3
RGD ID: 8886137
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); low-density lipoprotein particle receptor binding (ortholog); INVOLVED IN negative regulation of cell cycle phase transition (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of protein secretion (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 31 (ortholog); familial adenomatous polyposis 1 (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); cytosol (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: amyloid beta (A4) precursor protein-binding, family B, member 3; amyloid beta A4 precursor protein-binding family B member 3
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955418120,119 - 125,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955418118,577 - 126,021 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Apbb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955418120,119 - 125,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955418118,577 - 126,021 (+)NCBIChiLan1.0ChiLan1.0
APBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385140,558,268 - 140,564,598 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5140,558,268 - 140,564,781 (-)EnsemblGRCh38hg38GRCh38
GRCh375139,937,853 - 139,944,183 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365139,918,037 - 139,924,373 (-)NCBINCBI36Build 36hg18NCBI36
Celera5136,014,603 - 136,020,939 (-)NCBICelera
Cytogenetic Map5q31.3NCBI
HuRef5135,083,190 - 135,089,524 (-)NCBIHuRef
CHM1_15139,371,101 - 139,377,437 (-)NCBICHM1_1
T2T-CHM13v2.05141,083,699 - 141,090,029 (-)NCBIT2T-CHM13v2.0
Apbb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391836,804,207 - 36,812,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1836,804,207 - 36,812,419 (-)EnsemblGRCm39 Ensembl
GRCm381836,671,154 - 36,679,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1836,671,154 - 36,679,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv371836,830,813 - 36,839,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361836,797,133 - 36,805,340 (-)NCBIMGSCv36mm8
Celera1837,120,261 - 37,128,499 (-)NCBICelera
Cytogenetic Map18B2NCBI
cM Map1819.46NCBI
Apbb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81828,547,205 - 28,554,383 (-)NCBIGRCr8
mRatBN7.21828,273,168 - 28,280,347 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1828,270,545 - 28,280,094 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1828,400,313 - 28,407,491 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01829,162,404 - 29,169,582 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01828,497,642 - 28,504,820 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01829,497,865 - 29,504,995 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1829,497,863 - 29,504,995 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01829,202,939 - 29,210,069 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41829,310,421 - 29,317,546 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11829,337,068 - 29,344,192 (-)NCBI
Celera1828,000,350 - 28,007,475 (-)NCBICelera
Cytogenetic Map18p11NCBI
APBB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24135,815,801 - 135,822,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15133,955,352 - 133,961,698 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05135,922,662 - 135,928,995 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15142,039,819 - 142,046,157 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5142,039,818 - 142,046,157 (-)Ensemblpanpan1.1panPan2
APBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1235,753,212 - 35,759,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl235,753,241 - 35,759,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha232,791,445 - 32,797,399 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0236,207,844 - 36,213,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl236,207,844 - 36,213,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1233,260,715 - 33,266,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0234,128,254 - 34,134,207 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0234,880,947 - 34,886,901 (-)NCBIUU_Cfam_GSD_1.0
Apbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213152,079,566 - 152,085,626 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365319,526,185 - 9,531,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365319,525,879 - 9,531,943 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APBB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2142,313,777 - 142,320,730 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12142,307,049 - 142,320,725 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22148,257,916 - 148,264,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12343,202,835 - 43,209,401 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2343,203,152 - 43,209,109 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603434,675,252 - 34,681,584 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apbb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474333,322,792 - 33,328,391 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474333,322,496 - 33,328,567 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004714   ⟹   ENSCLAP00000004628
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955418120,119 - 125,711 (+)Ensembl
RefSeq Acc Id: XM_005382021   ⟹   XP_005382078
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955418119,977 - 126,021 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005382024   ⟹   XP_005382081
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955418119,977 - 126,021 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512904   ⟹   XP_013368358
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955418119,977 - 126,021 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512905   ⟹   XP_013368359
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955418118,577 - 126,021 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005382078 (Get FASTA)   NCBI Sequence Viewer  
  XP_005382081 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368358 (Get FASTA)   NCBI Sequence Viewer  
  XP_013368359 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000004628
  ENSCLAP00000004628.1
Reference Protein Sequences
RefSeq Acc Id: XP_005382078   ⟸   XM_005382021
- Peptide Label: isoform X3
- UniProtKB: A0A8C2UR62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005382081   ⟸   XM_005382024
- Peptide Label: isoform X1
- UniProtKB: A0A8C2UR62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368359   ⟸   XM_013512905
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UR62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013368358   ⟸   XM_013512904
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UR62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000004628   ⟸   ENSCLAT00000004714
Protein Domains
PID   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000004714 ENTREZGENE
  ENSCLAT00000004714.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro APBB1/2/3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
NCBI Gene Apbb3 ENTREZGENE
PANTHER AMYLOID-BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 3 UniProtKB/TrEMBL
  PTHR14058 UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PROSITE PID UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART PTB UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0A8C2UR62 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Apbb3  amyloid beta precursor protein binding family B member 3    amyloid beta (A4) precursor protein-binding, family B, member 3  Symbol and/or name change 5135510 APPROVED