Gba2 (glucosylceramidase beta 2) - Rat Genome Database

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Gene: Gba2 (glucosylceramidase beta 2) Chinchilla lanigera
Analyze
Symbol: Gba2
Name: glucosylceramidase beta 2
RGD ID: 8865576
Description: ENCODES a protein that exhibits beta-glucosidase activity (ortholog); glucosylceramidase activity (ortholog); glucosyltransferase activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); central nervous system neuron development (ortholog); cholesterol metabolic process (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum membrane (ortholog); Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glucosidase, beta (bile acid) 2; non-lysosomal glucosylceramidase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472553,556 - 564,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472553,556 - 564,411 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gba2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472553,556 - 564,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472553,556 - 564,411 (+)NCBIChiLan1.0ChiLan1.0
GBA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,736,866 - 35,749,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,736,866 - 35,749,228 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,736,863 - 35,749,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,726,863 - 35,739,225 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,726,863 - 35,739,225NCBI
Celera935,670,413 - 35,682,776 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,692,483 - 35,704,845 (-)NCBIHuRef
CHM1_1935,737,266 - 35,749,629 (-)NCBICHM1_1
T2T-CHM13v2.0935,757,546 - 35,769,909 (-)NCBIT2T-CHM13v2.0
Gba2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,566,928 - 43,578,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,566,928 - 43,578,873 (-)EnsemblGRCm39 Ensembl
GRCm38443,566,928 - 43,578,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,566,928 - 43,578,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,579,800 - 43,591,736 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,588,037 - 43,599,649 (-)NCBIMGSCv36mm8
Celera443,600,917 - 43,612,853 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Gba2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,618,176 - 62,630,160 (-)NCBIGRCr8
mRatBN7.2557,822,389 - 57,834,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,822,389 - 57,834,072 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,802,219 - 59,813,868 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,621,035 - 61,632,684 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,592,498 - 61,604,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,068,081 - 59,079,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,068,081 - 59,079,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,592,675 - 63,604,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,045,397 - 60,057,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,045,575 - 60,057,254 (-)NCBI
Celera556,402,961 - 56,414,599 (-)NCBICelera
Cytogenetic Map5q22NCBI
GBA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,839,627 - 88,851,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,845,445 - 88,857,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,587,876 - 35,599,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,390,407 - 36,402,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,390,409 - 36,402,949 (-)Ensemblpanpan1.1panPan2
GBA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,264,959 - 52,277,298 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,265,070 - 52,277,213 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,832,513 - 50,844,997 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,329,882 - 53,342,367 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,329,897 - 53,342,066 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,874,428 - 51,886,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,857,946 - 51,870,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,560,096 - 52,572,581 (-)NCBIUU_Cfam_GSD_1.0
Gba2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,183,253 - 167,194,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,730,833 - 3,742,531 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,730,833 - 3,742,526 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GBA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,455,240 - 236,468,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,456,238 - 236,467,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,181,426 - 264,193,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GBA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,852,048 - 44,865,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,852,203 - 44,868,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,956,699 - 41,969,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gba2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,045,594 - 5,056,416 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,045,566 - 5,056,419 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008829   ⟹   ENSCLAP00000008701
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955472553,556 - 564,411 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000008830   ⟹   ENSCLAP00000008702
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955472554,775 - 560,295 (+)Ensembl
RefSeq Acc Id: XM_005401007   ⟹   XP_005401064
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955472553,556 - 564,411 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005401064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000008701
  ENSCLAP00000008701.1
  ENSCLAP00000008702.1
Reference Protein Sequences
RefSeq Acc Id: XP_005401064   ⟸   XM_005401007
- UniProtKB: A0A8C2YM34 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000008702   ⟸   ENSCLAT00000008830
RefSeq Acc Id: ENSCLAP00000008701   ⟸   ENSCLAT00000008829
Protein Domains
Glycosyl-hydrolase family 116 catalytic region   Glycosyl-hydrolase family 116 N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006092 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008829 ENTREZGENE
  ENSCLAT00000008829.1 UniProtKB/TrEMBL
  ENSCLAT00000008830.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/TrEMBL
  6hp_glycosidase-like_sf UniProtKB/TrEMBL
  B_Glucosidase_GBA2-typ UniProtKB/TrEMBL
  GH116_catalytic UniProtKB/TrEMBL
  GH116_N UniProtKB/TrEMBL
NCBI Gene Gba2 ENTREZGENE
PANTHER BILE ACID BETA-GLUCOSIDASE-RELATED UniProtKB/TrEMBL
  NON-LYSOSOMAL GLUCOSYLCERAMIDASE UniProtKB/TrEMBL
Pfam DUF608 UniProtKB/TrEMBL
  Glyco_hydr_116N UniProtKB/TrEMBL
PIRSF Beta_gluc_GBA2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48208 UniProtKB/TrEMBL
UniProt A0A8C2V1U2_CHILA UniProtKB/TrEMBL
  A0A8C2YM34 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Gba2  glucosylceramidase beta 2    glucosidase, beta (bile acid) 2  Symbol and/or name change 5135510 APPROVED