GBA2 (glucosylceramidase beta 2) - Rat Genome Database

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Gene: GBA2 (glucosylceramidase beta 2) Pan paniscus
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Symbol: GBA2
Name: glucosylceramidase beta 2
RGD ID: 12031762
Description: ENCODES a protein that exhibits beta-glucosidase activity (inferred); glucosylceramidase activity (inferred); glucosyltransferase activity (inferred); INVOLVED IN bile acid metabolic process (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytosol (inferred); endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: non-lysosomal glucosylceramidase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,839,627 - 88,851,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,845,445 - 88,857,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,587,876 - 35,599,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,390,407 - 36,402,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,390,409 - 36,402,949 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GBA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,839,627 - 88,851,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,845,445 - 88,857,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0935,587,876 - 35,599,971 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,390,407 - 36,402,949 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,390,409 - 36,402,949 (-)Ensemblpanpan1.1panPan2
GBA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,736,866 - 35,749,228 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,736,866 - 35,749,228 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,736,863 - 35,749,225 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,726,863 - 35,739,225 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,726,863 - 35,739,225NCBI
Celera935,670,413 - 35,682,776 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,692,483 - 35,704,845 (-)NCBIHuRef
CHM1_1935,737,266 - 35,749,629 (-)NCBICHM1_1
T2T-CHM13v2.0935,757,546 - 35,769,909 (-)NCBIT2T-CHM13v2.0
Gba2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,566,928 - 43,578,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,566,928 - 43,578,873 (-)EnsemblGRCm39 Ensembl
GRCm38443,566,928 - 43,578,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,566,928 - 43,578,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,579,800 - 43,591,736 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,588,037 - 43,599,649 (-)NCBIMGSCv36mm8
Celera443,600,917 - 43,612,853 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map423.05NCBI
Gba2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,618,176 - 62,630,160 (-)NCBIGRCr8
mRatBN7.2557,822,389 - 57,834,522 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,822,389 - 57,834,072 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,802,219 - 59,813,868 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,621,035 - 61,632,684 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,592,498 - 61,604,154 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,068,081 - 59,079,719 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,068,081 - 59,079,719 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0563,592,675 - 63,604,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,045,397 - 60,057,035 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,045,575 - 60,057,254 (-)NCBI
Celera556,402,961 - 56,414,599 (-)NCBICelera
Cytogenetic Map5q22NCBI
Gba2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955472553,556 - 564,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955472553,556 - 564,411 (+)NCBIChiLan1.0ChiLan1.0
GBA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,264,959 - 52,277,298 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,265,070 - 52,277,213 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,832,513 - 50,844,997 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,329,882 - 53,342,367 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,329,897 - 53,342,066 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,874,428 - 51,886,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,857,946 - 51,870,446 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01152,560,096 - 52,572,581 (-)NCBIUU_Cfam_GSD_1.0
Gba2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,183,253 - 167,194,759 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,730,833 - 3,742,531 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,730,833 - 3,742,526 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GBA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,455,240 - 236,468,210 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,456,238 - 236,467,887 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21264,181,426 - 264,193,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GBA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,852,048 - 44,865,542 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,852,203 - 44,868,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,956,699 - 41,969,099 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gba2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248685,045,594 - 5,056,416 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248685,045,566 - 5,056,419 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000061844   ⟹   ENSPPAP00000038935
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,390,409 - 36,402,949 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061849   ⟹   ENSPPAP00000038940
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,390,710 - 36,402,421 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061852   ⟹   ENSPPAP00000038943
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl936,391,017 - 36,402,421 (-)Ensembl
RefSeq Acc Id: XM_003829839   ⟹   XP_003829887
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,839,632 - 88,851,447 (+)NCBI
NHGRI_mPanPan1988,845,567 - 88,857,385 (+)NCBI
Mhudiblu_PPA_v0935,587,878 - 35,599,971 (-)NCBI
PanPan1.1936,390,409 - 36,402,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955235   ⟹   XP_008953483
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,839,632 - 88,851,447 (+)NCBI
NHGRI_mPanPan1988,845,567 - 88,857,385 (+)NCBI
Mhudiblu_PPA_v0935,587,876 - 35,599,687 (-)NCBI
PanPan1.1936,390,407 - 36,402,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024930211   ⟹   XP_024785979
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,839,627 - 88,850,837 (+)NCBI
NHGRI_mPanPan1988,845,445 - 88,856,775 (+)NCBI
Mhudiblu_PPA_v0935,588,476 - 35,599,816 (-)NCBI
PanPan1.1936,390,995 - 36,402,556 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063594406   ⟹   XP_063450476
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,839,632 - 88,851,447 (+)NCBI
RefSeq Acc Id: XM_063594407   ⟹   XP_063450477
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21188,839,632 - 88,851,447 (+)NCBI
RefSeq Acc Id: XP_008953483   ⟸   XM_008955235
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CAF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003829887   ⟸   XM_003829839
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CAF1 (UniProtKB/TrEMBL),   A0A2R9CAF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785979   ⟸   XM_024930211
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CD68 (UniProtKB/TrEMBL),   A0A2R9CAF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000038940   ⟸   ENSPPAT00000061849
RefSeq Acc Id: ENSPPAP00000038935   ⟸   ENSPPAT00000061844
RefSeq Acc Id: ENSPPAP00000038943   ⟸   ENSPPAT00000061852
RefSeq Acc Id: XP_063450476   ⟸   XM_063594406
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063450477   ⟸   XM_063594407
- Peptide Label: isoform X3

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042172 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061844.1 UniProtKB/TrEMBL
  ENSPPAT00000061849.1 UniProtKB/TrEMBL
  ENSPPAT00000061852.1 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
InterPro 6-hairpin_glycosidase_sf UniProtKB/TrEMBL
  6hp_glycosidase-like_sf UniProtKB/TrEMBL
  B_Glucosidase_GBA2-typ UniProtKB/TrEMBL
  GH116_catalytic UniProtKB/TrEMBL
  GH116_N UniProtKB/TrEMBL
KEGG Report pps:100989101 UniProtKB/TrEMBL
NCBI Gene GBA2 ENTREZGENE
PANTHER BILE ACID BETA-GLUCOSIDASE-RELATED UniProtKB/TrEMBL
  NON-LYSOSOMAL GLUCOSYLCERAMIDASE UniProtKB/TrEMBL
Pfam DUF608 UniProtKB/TrEMBL
  Glyco_hydr_116N UniProtKB/TrEMBL
PIRSF Beta_gluc_GBA2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48208 UniProtKB/TrEMBL
UniProt A0A2R9CAF1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CAF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CD68 ENTREZGENE, UniProtKB/TrEMBL