Gene: Gba2 (glucosidase beta 2)
Rattus norvegicus
Symbol:
Gba2
Name:
glucosidase beta 2
Description:
ENCODES a protein that exhibits beta-glucosidase activity (ortholog); INVOLVED IN bile acid metabolic process (ortholog); glycoside catabolic process (ortholog); FOUND IN integral to membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; N-nitrosodiethylamine
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
beta-glucocerebrosidase 2; beta-glucosidase 2; bile acid beta-glucosidase; Gba2_predicted; glucosidase beta 2 (predicted); glucosylceramidase 2; LOC298399; NLGase; non-lysosomal glucosylceramidase
Orthologs:
Homo sapiens : GBA2
(glucosidase, beta (bile acid) 2)
HGNC
Gba2
(glucosidase beta 2)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 5 q22 NCBI RGSC Genome Assembly v5.0 5 63,592,675 - 63,604,313 - NCBI RGSC Genome Assembly v3.4 5 60,045,397 - 60,057,035 - NCBI Rat Celera Assembly 5 56,402,961 - 56,414,599 - NCBI Genome Assembly 3.1 5 60,045,575 - 60,057,254 - NCBI
Model
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1313721 6480464 Tetrachlorodibenzodioxin results in decreased expression of GBA2 mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1313722 6480464 Tetrachlorodibenzodioxin affects the expression of GBA2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of GBA2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1313722 6480464 Tetrachlorodibenzodioxin results in decreased expression of GBA2 mRNA CTD PMID:19684285 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of GBA2 mRNA CTD PMID:21346803 2-methylcholine affects expression ISO RGD:1313721 6480464 beta-methylcholine affects the expression of GBA2 mRNA CTD PMID:21179406 3,3',4,4'-tetrachlorobiphenyl multiple interactions ISO RGD:1313722 6480464 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of GBA2 mRNA] CTD PMID:19467301 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1313722 6480464 4,4'-diaminodiphenylmethane results in decreased expression of GBA2 mRNA CTD PMID:18648102 cobalt dichloride decreases expression ISO RGD:1313721 6480464 cobaltous chloride results in decreased expression of GBA2 mRNA CTD PMID:19320972 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GBA2 mRNA CTD PMID:18164116 paracetamol affects expression ISO RGD:1313722 6480464 Acetaminophen affects the expression of GBA2 mRNA CTD PMID:17562736 phenobarbital increases expression ISO RGD:1313722 6480464 Phenobarbital results in increased expression of GBA2 mRNA CTD PMID:19270015 tetracycline increases expression ISO RGD:1313722 6480464 Tetracycline results in increased expression of GBA2 mRNA CTD PMID:16917069 valproic acid affects expression ISO RGD:1313722 6480464 Valproic Acid affects the expression of GBA2 mRNA CTD PMID:17292431
Gene Ontology Annotations
Biological Process bile acid metabolic process ISO RGD:1313721 1624291 PMID:17105727 RGD PMID:17105727 bile acid metabolic process ISS UniProtKB:Q9HCG7 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024 glucosylceramide catabolic process IEA InterPro:IPR014551 1600115 GO_REF:0000002 InterPro GO_REF:0000002 glycoside catabolic process ISO RGD:1313721 1624291 PMID:17105727 RGD PMID:17105727 glycoside catabolic process ISS UniProtKB:Q9HCG7 1600115 GO_REF:0000024 UniProtKB GO_REF:0000024
70189 Mcs5 Mammary carcinoma susceptibility QTL 5 10.51 Mammary tumor susceptibility 5 58063971 139156771 Rat 634305 Mamtr1 Mammary tumor resistance QTL 1 .0001 Mammary tumor resistance 7,12-dimethylbenzanthracene induced 5 12880403 119333229 Rat 1298067 Scl15 Serum cholesterol level QTL 15 4.8 .001 Lipid level cholesterol 5 35474610 80474610 Rat 1331801 Rf33 Renal function QTL 33 4.149 Renal function renal vascular resistance 5 45499364 135916908 Rat 61359 Eaex Experimental allergic encephalomyelitis QTL x 3 Brain/spinal cord inflammation onset of disease 5 57974567 102974567 Rat 70212 Niddm25 Non-insulin dependent diabetes mellitus QTL 25 3.54 Glucose level fasting 5 1 138272129 Rat 1302786 Kidm8 Kidney mass QTL 8 28.15 Kidney mass 5 35474610 80474610 Rat 1300115 Hrtrt7 Heart rate QTL 7 2.76 Heart rate salt-loaded 5 49767270 89261520 Rat 1331773 Scl26 Serum cholesterol QTL 26 3.065 Lipid level cholesterol 5 45499364 90620456 Rat 1331782 Rf36 Renal function QTL 36 3.296 Renal function renal blood flow 5 35390492 101506667 Rat 1331771 Rf35 Renal function QTL 35 4.36965 Renal function renal blood flow 5 378448 90620456 Rat 1331756 Rf34 Renal function QTL 34 4.16275 Renal function renal blood flow 5 1 94516069 Rat 1549845 Scl44 Serum cholesterol level QTL 44 6 Lipid level serum cholesterol, post dietary 5 41498818 155121024 Rat 1576314 Eutr1 Estrogen induced uterine response QTL 1 Uterine inflammation estrogen-induced 5 1220773 79863911 Rat 1576317 Eutr2 Estrogen induced uterine response QTL 2 .01 Uterine inflammation estrogen-induced 5 35911094 109163425 Rat 1598807 Glom12 Glomerulus QTL 12 2.7 Renal pathology glomerular injury score 5 35474610 80474610 Rat 1578766 Tcas11 Tongue tumor susceptibility QTL 11 4.12 Tongue tumor susceptibility tongue tumor number 5 17517235 168005953 Rat 1578776 Stresp18 Stress response QTL 18 2.9 Stress response thymus weight 5 30030683 75030683 Rat 1641912 Alcrsp18 Alcohol response QTL 18 Alcohol response loss of righting reflex 5 36386126 148460381 Rat 1641922 Alcrsp8 Alcohol response QTL 8 Alcohol response blood ethanol concentration 5 36386126 71377566 Rat 1358353 Srcrtb2 Stress Responsive Cort Basal QTL 2 3.48 .003 Hypothalamic-pituitary-adrenal axis corticosterone 5 19206257 77484299 Rat 2290448 Scl54 Serum cholesterol level QTL 54 2.93 Lipid level cholesterol level 5 32701659 138272129 Rat 1600358 Mamtr5 Mammary tumor resistance QTL 5 Mammary tumor resistance 5 19206257 64206257 Rat 2303574 Gluco42 Glucose level QTL 42 2 Glucose level fasting 5 57040762 102040762 Rat 2303615 Vencon7 Ventilatory control QTL 7 .001 Ventilatory control re-oxygenation after hypoxia 5 54207464 99207464 Rat 2316959 Gluco59 Glucose level QTL 59 4.7 Glucose level postprandial 5 17517235 119332868 Rat 6903292 Stl28 Serum triglyceride level QTL 28 2.6 .0073 Lipid level triglyceride level 5 30606308 75606308 Rat 6903306 Scl35 Serum cholesterol QTL 35 2.6 .0073 Lipid level cholesterol level 5 30606308 75606308 Rat 1576312 Emca8 Estrogen-induced mammary cancer QTL 8 4.1 Mammary tumor susceptibility estradiol-induced 5 52434178 148460381 Rat
Gene Ontology Annotations
