Ei24 (EI24 autophagy associated transmembrane protein)

Gene: Ei24 (EI24 autophagy associated transmembrane protein) Chinchilla lanigera

Analyze

Symbol:

Ei24

Name:

EI24 autophagy associated transmembrane protein

RGD ID:

8837074

Description:

ENCODES a protein that exhibits importin-alpha family protein binding (ortholog); INVOLVED IN autophagy (ortholog); cellular response to UV-C (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage (ortholog); ASSOCIATED WITH Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); holoprosencephaly 11 (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); Golgi apparatus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

etoposide induced 2.4; etoposide-induced protein 2.4 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	26,574,866 - 26,585,161 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	26,574,814 - 26,586,154 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chromosome 11, Partial Trisomy 11q (ISO)

Dwarfism (ISO)

holoprosencephaly 11 (ISO)

intellectual disability (ISO)

Jacobsen Syndrome (ISO)

Prostatic Neoplasms (ISO)

schizophrenia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagy (ISO)

cellular response to UV-C (ISO)

intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

negative regulation of cell growth (ISO)

negative regulation of protein import into nucleus (ISO)

neuromuscular process controlling balance (ISO)

positive regulation of intrinsic apoptotic signaling pathway (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

cytosol (ISO)

endoplasmic reticulum (ISO)

Golgi apparatus (ISO)

Molecular Function

importin-alpha family protein binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ei24
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	26,574,866 - 26,585,161 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	26,574,814 - 26,586,154 (+)	NCBI	ChiLan1.0	ChiLan1.0

EI24
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	125,569,477 - 125,584,684 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	125,569,280 - 125,584,684 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	125,439,373 - 125,454,579 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	124,944,508 - 124,959,785 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	124,944,507 - 124,959,784	NCBI
Celera	11	122,599,610 - 122,614,886 (+)	NCBI		Celera
Cytogenetic Map	11	q24.2	NCBI
HuRef	11	121,380,862 - 121,396,124 (+)	NCBI		HuRef
CHM1_1	11	125,325,451 - 125,340,728 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	125,598,125 - 125,613,333 (+)	NCBI		T2T-CHM13v2.0

Ei24
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	36,690,449 - 36,708,630 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	36,690,455 - 36,708,689 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	36,779,153 - 36,797,334 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	36,779,159 - 36,797,393 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	36,586,740 - 36,604,653 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	36,528,826 - 36,546,739 (-)	NCBI		MGSCv36	mm8
Celera	9	33,981,501 - 33,999,718 (-)	NCBI		Celera
Cytogenetic Map	9	A4	NCBI
cM Map	9	20.68	NCBI

Ei24
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	44,683,138 - 44,699,502 (-)	NCBI		GRCr8
mRatBN7.2	8	36,494,289 - 36,510,653 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	36,494,289 - 36,510,571 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	40,503,825 - 40,520,077 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	38,786,883 - 38,803,143 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	36,649,771 - 36,666,023 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	39,254,883 - 39,271,238 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	39,254,889 - 39,266,959 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	39,257,600 - 39,273,481 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	38,028,043 - 38,044,316 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	38,036,808 - 38,053,082 (-)	NCBI
Celera	8	37,930,578 - 37,946,563 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

EI24
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	126,258,080 - 126,273,317 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	127,362,564 - 127,377,780 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	120,389,136 - 120,404,347 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	124,302,289 - 124,317,346 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	124,302,289 - 124,317,346 (+)	Ensembl	panpan1.1		panPan2

EI24
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	8,949,886 - 8,963,967 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	8,950,883 - 8,963,967 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	8,995,125 - 9,009,082 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	8,890,483 - 8,904,437 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	8,890,357 - 8,904,437 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	8,962,275 - 8,976,216 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	8,932,736 - 8,946,687 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	8,969,329 - 8,983,282 (-)	NCBI		UU_Cfam_GSD_1.0

Ei24
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	107,708,434 - 107,722,877 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936743	1,958,829 - 1,969,540 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936743	1,957,948 - 1,970,885 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EI24
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	52,704,570 - 52,720,938 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	52,704,560 - 52,724,966 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	58,354,873 - 58,374,166 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EI24
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	116,711,922 - 116,727,208 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	116,714,578 - 116,726,216 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	9,343,470 - 9,358,915 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ei24
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624927	1,548,544 - 1,566,108 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005378462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01013199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01013200	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01039359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000022584 ⟹ ENSCLAP00000022379

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955412	26,574,866 - 26,585,161 (+)	Ensembl

RefSeq Acc Id:

XM_005378462 ⟹ XP_005378519

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955412	26,574,814 - 26,586,154 (+)	NCBI

Sequence:

show sequence

TCATGGTTCGTATGTTTCCAGGTCCTTCATGATGAGCTATTTGGGACACTCCTCTCTCTGTGTA
GTTGATAAGACGTCTGGTTGGTGAAGAGATGGCAGACAGTGTCAGAACCTTTCTCCAGGACCTT
GGCAGGGGAATCAAAGACTCCATCTGGGGCATTTGTACCATCTCAAAGATAGATGCTCGAATCC
AGCAGAAGAGAGAGGAGCAGCGTCGAAGAAGGGCTAGTAGTGTCTTGGCTCAGAGGAGAACCCA
GAGTATAGAGCGGAAGAAAGAAAGTGAGTCATGTATTGCTAGAAGAATTTTCCAGTGCTGTGCT
TGGAATGGTGGAGTATTCTGGTTAAGTCTCCTCTTGTTTTATCGAGTATTTATTCCTGTGCTTC
AGTCAGTAACAGCCCGGATTATTGGTGATCCATCCCTGCATGGAGACATTTGGTCTTGGCTGGA
ATTCTTCCTCACGTCGGTGTTCAGCGCTCTTTGGGTGCTCCCCCTGTTTGTGCTCAGCAAAATT
GTGAATGCCATTTGGTTTCAAGATATAGCTGACCTGGCATTTGAGGTATCGGGGAGAAAGCCTC
AACCATTCCCCAGCGTCAGCAAAATAATTGCTGACATGCTCTTCAACCTTTTGCTGCAGGCTCT
TTTCCTTATCCAGGGGATGTTTGTGAGTCTCTTTCCCATTCATCTTGTTGGTCAGCTGGTCAGT
CTGTTGCATATGTCCCTTCTCTACTCACTGTACTGCTTCGAGTATCGTTGGTTCAATAAAGGAA
TTGAAATGCATCAGCGGTTGTCAAACATAGAAAGGAATTGGCCTTACTACTTTGGATTTGGTCT
GCCCTTGGCTTTCCTCACAGCAATGCAGTCCTCGTATATTATCAGTGGCTGCCTCTTCTCTATC
CTTTTTCCTTTATTCATCATCAGCGCCAATGAAGCAAAGACCCCTGGAAAAGCATACCTTTTCC
AGTTGCGCCTCTTCTCCTTGGTGGTCTTCTTAAGCAACAGACTCTTCCATAAGACAGTCTATCT
GCAGTCTGCGCTGAGCAGCTCCACCTCTGCAGAGAAGTTCCCCTCACCGCATCCATCTCCTGCC
AAACTGAAGGCTGCTGCAGGCCACTGAGTCACCTGCCGTCCAGGGGCGATGGGTGGGGTTGGAG
GGAGGCTGTGGCAGCTCTTTTCTCTATTCTCCTTCCCTGGCCAGGAAAGGCAGGGCCCATTCTG
CCAAGGGTCCTCAGCGTATTCCCTTCTCTTTGAAGAATTGGAATTTTTGTCTCTGGTGCATGTA
GGGCAGAATCTTCCCGACACCAGTGCGTGGATTTTTAACACCATCATGAGTCTGAATGGACCAC
AGGTTTTTCTGTAGCTGTTTTCTAGCATTTGCCAGCCCCTGTGCCTGGACTGATTGGAATACTT
TGGTTTTTTCCCCTGTGCCATTTACCCTCCTCTGTCCTTTCTGCCTTCTAGCCCCTTTGGATGA
ATGAGTTTTGTAATTCTAGCTGTTGTATTTTGTGGATTTGTTATTTTTGTTTTTCTGTGAAGCA
CATACATTGGATGTGGGAGGAAAAGGAGTACATTGTCTCAGTTGCTCCTGCTCACTCCCGTTAT
AGCCATCACTGTCTTGTTTCTCGTAACTCAGGTTAGGTTTTGGTCTCTCTTGCTCTACTGCAAA
AAAGAAAAAAAGAGCTTGAAGAGATAGGACAGAAGGAAAGACCTCACAGCCAGATCAGCTAGGT
TTTGAGGAATAATTTTCTTTCTTCCCCTTGAAGGGGAAAAGGCTTTTCTTTCACTGGTACATTT
AAAGCTCCCCAGCTGTGGGGAGGTACCGATTCTGGACAAGTGCCACCGCAACAGAGAATGCCCA
GAGAACCTGAACTTTTCAGCTCTGAAGGGTGGAAATTTACTGTTGGCCACTGCCGTGTCTCACT
GGTATTTCAAAGGAATATTGGGTGCTGCAAATAGGAACTGAAGGGGTATACTTATTAAACCCAT
TAAACCTGTGAGTGGTGATGTTTTTTGTCCTTTTAAGAGACTAAATATGGGGAGGGAGGGCGGA
TGTCAAAACACTTGTAAAATTTTAAAATGTCACAATTAAACGTAAGCTGGCTTCCCAGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005378519	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022379
	ENSCLAP00000022379.1

RefSeq Acc Id:

XP_005378519 ⟸ XM_005378462

- UniProtKB:

A0A8C2W538 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADSVRTFLQDLGRGIKDSIWGICTISKIDARIQQKREEQRRRRASSVLAQRRTQSIERKKESE
SCIARRIFQCCAWNGGVFWLSLLLFYRVFIPVLQSVTARIIGDPSLHGDIWSWLEFFLTSVFSA
LWVLPLFVLSKIVNAIWFQDIADLAFEVSGRKPQPFPSVSKIIADMLFNLLLQALFLIQGMFVS
LFPIHLVGQLVSLLHMSLLYSLYCFEYRWFNKGIEMHQRLSNIERNWPYYFGFGLPLAFLTAMQ
SSYIISGCLFSILFPLFIISANEAKTPGKAYLFQLRLFSLVVFLSNRLFHKTVYLQSALSSSTS
AEKFPSPHPSPAKLKAAAGH

hide sequence

RefSeq Acc Id:

ENSCLAP00000022379 ⟸ ENSCLAT00000022584

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015350	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022584	ENTREZGENE
	ENSCLAT00000022584.1	UniProtKB/TrEMBL
NCBI Gene	Ei24	ENTREZGENE
PANTHER	ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG	UniProtKB/TrEMBL
	PTHR21389	UniProtKB/TrEMBL
Pfam	EI24	UniProtKB/TrEMBL
UniProt	A0A8C2W538	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	Ei24	EI24 autophagy associated transmembrane protein		EI24, autophagy associated transmembrane protein	Symbol and/or name change	5135510	APPROVED
2016-08-03	Ei24	EI24, autophagy associated transmembrane protein		etoposide induced 2.4	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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