RRM1 (ribonucleotide reductase catalytic subunit M1) - Rat Genome Database

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Gene: RRM1 (ribonucleotide reductase catalytic subunit M1) Homo sapiens
Analyze
Symbol: RRM1
Name: ribonucleotide reductase catalytic subunit M1
RGD ID: 737409
HGNC Page HGNC:10451
Description: Enables identical protein binding activity and ribonucleoside-diphosphate reductase activity. Involved in DNA metabolic process; nucleoside phosphate metabolic process; and positive regulation of cell cycle process. Located in ribonucleoside-diphosphate reductase complex. Implicated in chronic progressive external ophthalmoplegia. Biomarker of lung non-small cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: PEOB6; R1; ribonucleoside-diphosphate reductase large subunit; ribonucleoside-diphosphate reductase subunit M1; ribonucleotide reductase large subunit; ribonucleotide reductase M1 polypeptide; ribonucleotide reductase, large subunit; ribonucleotide reductase, R1 subunit; RIR1; RR1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38114,094,685 - 4,138,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl114,094,707 - 4,138,932 (+)EnsemblGRCh38hg38GRCh38
GRCh37114,115,915 - 4,160,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36114,072,500 - 4,116,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 34114,072,586 - 4,116,681NCBI
Celera114,120,880 - 4,164,701 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,849,345 - 3,893,165 (+)NCBIHuRef
CHM1_1114,115,391 - 4,159,561 (+)NCBICHM1_1
T2T-CHM13v2.0114,159,950 - 4,204,024 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (EXP)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbon nanotube  (EXP,ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (EXP)
gemcitabine  (EXP)
graphite  (EXP)
hydrogen peroxide  (EXP)
indometacin  (ISO)
ivermectin  (EXP)
lead(0)  (EXP)
lidocaine  (ISO)
menadione  (EXP)
methimazole  (ISO)
methylseleninic acid  (EXP)
Mitotane  (EXP)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (EXP)
quinoline  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
senecionine  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (ISO)
sunitinib  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vorinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
2. Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats. Dragan YP, etal., Mol Carcinog. 2004 Jul;40(3):150-9.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU. Zhu H, etal., Brain Res. 2005 Mar 2;1036(1-2):7-17.
Additional References at PubMed
PMID:1627826   PMID:1677928   PMID:1840662   PMID:3044582   PMID:3275546   PMID:3891388   PMID:7557993   PMID:8125298   PMID:8188248   PMID:8386696   PMID:8889548   PMID:9933563  
PMID:10441745   PMID:10716435   PMID:11517226   PMID:11719458   PMID:11781084   PMID:12477932   PMID:12578384   PMID:12615712   PMID:12687015   PMID:12789263   PMID:14583450   PMID:14702039  
PMID:14729598   PMID:15172981   PMID:15277258   PMID:15324660   PMID:15342556   PMID:15489334   PMID:16169070   PMID:16376858   PMID:16476973   PMID:16481328   PMID:16966686   PMID:17064812  
PMID:17065054   PMID:17131328   PMID:17486094   PMID:17602053   PMID:17726094   PMID:18414411   PMID:18483375   PMID:18494946   PMID:18636187   PMID:18997010   PMID:19304340   PMID:19543324  
PMID:19552012   PMID:20021860   PMID:20028759   PMID:20043067   PMID:20159953   PMID:20211060   PMID:20226083   PMID:20453000   PMID:20467918   PMID:20587610   PMID:20627363   PMID:20811706  
PMID:20819778   PMID:20868593   PMID:21145461   PMID:21220199   PMID:21264835   PMID:21319273   PMID:21336276   PMID:21370501   PMID:21382349   PMID:21394302   PMID:21424698   PMID:21628579  
PMID:21642870   PMID:21873635   PMID:22134350   PMID:22268729   PMID:22632967   PMID:22705007   PMID:22863883   PMID:22939629   PMID:23086647   PMID:23155271   PMID:23166591   PMID:23249808  
PMID:23376485   PMID:23401439   PMID:23519412   PMID:23552804   PMID:23803067   PMID:23922955   PMID:23948418   PMID:23982437   PMID:23991987   PMID:24024897   PMID:24045016   PMID:24155212  
PMID:24215511   PMID:24253041   PMID:24266856   PMID:24361227   PMID:24434653   PMID:24578158   PMID:24591771   PMID:24595080   PMID:24614341   PMID:24861915   PMID:25032731   PMID:25078585  
PMID:25113059   PMID:25227663   PMID:25256246   PMID:25416956   PMID:25497672   PMID:25560468   PMID:25638032   PMID:25837929   PMID:25840756   PMID:25921289   PMID:26028097   PMID:26083014  
PMID:26186194   PMID:26200905   PMID:26228206   PMID:26252353   PMID:26254808   PMID:26264872   PMID:26323924   PMID:26344197   PMID:26496610   PMID:26508657   PMID:26511642   PMID:26542178  
PMID:26612755   PMID:26637889   PMID:26638075   PMID:26650486   PMID:26718430   PMID:26752685   PMID:26828016   PMID:26972000   PMID:27173327   PMID:27179014   PMID:27342126   PMID:27566080  
PMID:27587543   PMID:27908619   PMID:28066957   PMID:28380382   PMID:28411237   PMID:28416140   PMID:28442502   PMID:28507282   PMID:28514442   PMID:28515276   PMID:28624910   PMID:29149599  
PMID:29214667   PMID:29467282   PMID:29564676   PMID:29845934   PMID:29865035   PMID:30033366   PMID:30150681   PMID:30458017   PMID:30503554   PMID:30711629   PMID:30833792   PMID:31024071  
PMID:31046837   PMID:31091453   PMID:31340801   PMID:31478661   PMID:31586073   PMID:31617661   PMID:31822713   PMID:32296183   PMID:32324262   PMID:32687490   PMID:32712628   PMID:32786267  
PMID:32842027   PMID:32941674   PMID:33239621   PMID:33306668   PMID:33545068   PMID:33742100   PMID:33921102   PMID:33957083   PMID:33961781   PMID:34111175   PMID:34135160   PMID:34353292  
PMID:34373451   PMID:34901782   PMID:34921012   PMID:35013556   PMID:35256949   PMID:35271311   PMID:35384245   PMID:35509820   PMID:35563538   PMID:35696571   PMID:35831314   PMID:35944360  
PMID:36114006   PMID:36168627   PMID:36215168   PMID:36261009   PMID:36398858   PMID:36866763   PMID:37827155   PMID:38040978   PMID:38113892  


Genomics

Comparative Map Data
RRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38114,094,685 - 4,138,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl114,094,707 - 4,138,932 (+)EnsemblGRCh38hg38GRCh38
GRCh37114,115,915 - 4,160,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36114,072,500 - 4,116,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 34114,072,586 - 4,116,681NCBI
Celera114,120,880 - 4,164,701 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,849,345 - 3,893,165 (+)NCBIHuRef
CHM1_1114,115,391 - 4,159,561 (+)NCBICHM1_1
T2T-CHM13v2.0114,159,950 - 4,204,024 (+)NCBIT2T-CHM13v2.0
Rrm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397102,090,902 - 102,118,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7102,090,902 - 102,118,978 (+)EnsemblGRCm39 Ensembl
GRCm387102,441,695 - 102,469,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,441,695 - 102,469,771 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,590,209 - 109,618,285 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,315,688 - 102,342,747 (+)NCBIMGSCv36mm8
Celera7102,809,638 - 102,837,567 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map754.72NCBI
Rrm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,235,904 - 166,260,206 (+)NCBIGRCr8
mRatBN7.21156,823,960 - 156,848,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,823,960 - 156,848,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,801,707 - 164,826,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,981,799 - 172,006,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,859,508 - 164,883,799 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,538,387 - 167,562,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,538,263 - 167,562,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,726,994 - 173,751,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,930,994 - 159,937,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1154,890,871 - 154,915,173 (+)NCBICelera
Cytogenetic Map1q32NCBI
Rrm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,850,530 - 19,905,266 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,850,523 - 19,904,879 (+)NCBIChiLan1.0ChiLan1.0
RRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v296,348,683 - 6,392,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,588,407 - 5,632,547 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,956,528 - 3,999,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1114,068,119 - 4,110,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl114,068,119 - 4,110,474 (+)Ensemblpanpan1.1panPan2
RRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,595,838 - 26,631,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,595,914 - 26,631,135 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,365,162 - 26,400,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,805,233 - 26,840,936 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,805,323 - 26,840,930 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,595,614 - 26,630,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,811,885 - 26,847,337 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,714,390 - 26,749,830 (+)NCBIUU_Cfam_GSD_1.0
Rrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,215,865 - 59,249,179 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936498815,399 - 848,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936498815,401 - 848,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,025,073 - 6,065,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,026,151 - 6,065,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.296,818,979 - 6,880,069 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,606,112 - 62,649,979 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,604,486 - 62,650,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604363,252,138 - 63,296,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248175,523,665 - 5,568,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,523,648 - 5,568,997 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RRM1
27 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.4(chr11:3745061-7846057)x3 copy number gain See cases [RCV000053616] Chr11:3745061..7846057 [GRCh38]
Chr11:3766291..7867604 [GRCh37]
Chr11:3722867..7824180 [NCBI36]
Chr11:11p15.4
pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
NM_001033.3(RRM1):c.1057C>T (p.Pro353Ser) single nucleotide variant Malignant melanoma [RCV000069351] Chr11:4122159 [GRCh38]
Chr11:4143389 [GRCh37]
Chr11:4099965 [NCBI36]
Chr11:11p15.4
not provided
GRCh37/hg19 11p15.5-15.4(chr11:10701-5080415)x2 copy number gain See cases [RCV001310286] Chr11:10701..5080415 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh38/hg38 11p15.4(chr11:3685244-4414881)x3 copy number gain See cases [RCV000141996] Chr11:3685244..4414881 [GRCh38]
Chr11:3706474..4436111 [GRCh37]
Chr11:3663050..4392687 [NCBI36]
Chr11:11p15.4
uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.4(chr11:3898872-4853895)x1 copy number loss See cases [RCV000240109] Chr11:3898872..4853895 [GRCh37]
Chr11:11p15.4
uncertain significance
GRCh37/hg19 11p15.5-15.4(chr11:193187-5291338)x3 copy number gain See cases [RCV000446036] Chr11:193187..5291338 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-6644927)x3 copy number gain See cases [RCV000449417] Chr11:230615..6644927 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.4(chr11:3629582-4677492)x3 copy number gain See cases [RCV000511398] Chr11:3629582..4677492 [GRCh37]
Chr11:11p15.4
likely benign
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-9704511)x3 copy number gain not provided [RCV000683369] Chr11:230615..9704511 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_001033.5(RRM1):c.361T>C (p.Leu121=) single nucleotide variant not provided [RCV000906596] Chr11:4107509 [GRCh38]
Chr11:4128739 [GRCh37]
Chr11:11p15.4
benign
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Silver-Russell syndrome 1 [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
NM_001033.5(RRM1):c.1659C>T (p.Tyr553=) single nucleotide variant not provided [RCV000892625] Chr11:4127223 [GRCh38]
Chr11:4148453 [GRCh37]
Chr11:11p15.4
benign
NM_001033.5(RRM1):c.1490G>A (p.Arg497His) single nucleotide variant not provided [RCV000956887] Chr11:4127054 [GRCh38]
Chr11:4148284 [GRCh37]
Chr11:11p15.4
likely benign
GRCh37/hg19 11p15.5-15.4(chr11:230616-8250724)x3 copy number gain not provided [RCV002472435] Chr11:230616..8250724 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:210300-8664358)x3 copy number gain Silver-Russell syndrome 1 [RCV001263222] Chr11:210300..8664358 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-4851537)x3 copy number gain See cases [RCV001263059] Chr11:230615..4851537 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-5525355)x3 copy number gain not provided [RCV001825269] Chr11:230615..5525355 [GRCh37]
Chr11:11p15.5-15.4
not provided
NC_000011.10:g.(499700_4999400)_(5279346_5279697)del deletion Thalassemia, gamma-delta-beta [RCV000015529] Chr11:4999400..5279346 [GRCh38]
Chr11:11p15.5-15.4
pathogenic
GRCh37/hg19 11p15.5-14.2(chr11:230615-26881146)x3 copy number gain See cases [RCV002286351] Chr11:230615..26881146 [GRCh37]
Chr11:11p15.5-14.2
pathogenic
NM_001033.5(RRM1):c.1142G>A (p.Arg381His) single nucleotide variant Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 [RCV003447337]|RRM1-related disorder [RCV003153041] Chr11:4123206 [GRCh38]
Chr11:4144436 [GRCh37]
Chr11:11p15.4
pathogenic|uncertain significance
NM_001033.5(RRM1):c.1681G>C (p.Val561Leu) single nucleotide variant Inborn genetic diseases [RCV003288233] Chr11:4127245 [GRCh38]
Chr11:4148475 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1703A>G (p.Tyr568Cys) single nucleotide variant Inborn genetic diseases [RCV002879820] Chr11:4129084 [GRCh38]
Chr11:4150314 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1964T>C (p.Met655Thr) single nucleotide variant Inborn genetic diseases [RCV002864887] Chr11:4133621 [GRCh38]
Chr11:4154851 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1562G>A (p.Ser521Asn) single nucleotide variant Inborn genetic diseases [RCV002708239] Chr11:4127126 [GRCh38]
Chr11:4148356 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.2014A>G (p.Ile672Val) single nucleotide variant Inborn genetic diseases [RCV002744602] Chr11:4135094 [GRCh38]
Chr11:4156324 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.304T>C (p.Tyr102His) single nucleotide variant Inborn genetic diseases [RCV002896829] Chr11:4107452 [GRCh38]
Chr11:4128682 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.829A>G (p.Arg277Gly) single nucleotide variant Inborn genetic diseases [RCV002652698] Chr11:4119881 [GRCh38]
Chr11:4141111 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1747G>T (p.Val583Phe) single nucleotide variant Inborn genetic diseases [RCV002724190] Chr11:4129128 [GRCh38]
Chr11:4150358 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.388C>T (p.Arg130Cys) single nucleotide variant Inborn genetic diseases [RCV002944572] Chr11:4109644 [GRCh38]
Chr11:4130874 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1640C>G (p.Ala547Gly) single nucleotide variant Inborn genetic diseases [RCV003200427] Chr11:4127204 [GRCh38]
Chr11:4148434 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.2069C>G (p.Thr690Ser) single nucleotide variant Inborn genetic diseases [RCV003219398] Chr11:4135149 [GRCh38]
Chr11:4156379 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.2261A>C (p.Lys754Thr) single nucleotide variant Inborn genetic diseases [RCV003304821] Chr11:4138265 [GRCh38]
Chr11:4159495 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1321G>A (p.Val441Ile) single nucleotide variant Inborn genetic diseases [RCV003345600] Chr11:4126684 [GRCh38]
Chr11:4147914 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.58T>C (p.Ser20Pro) single nucleotide variant not provided [RCV003456762] Chr11:4102031 [GRCh38]
Chr11:4123261 [GRCh37]
Chr11:11p15.4
uncertain significance
NM_001033.5(RRM1):c.1141C>T (p.Arg381Cys) single nucleotide variant Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 [RCV003447444] Chr11:4123205 [GRCh38]
Chr11:4144435 [GRCh37]
Chr11:11p15.4
pathogenic
GRCh37/hg19 11p15.5-15.4(chr11:230615-8821443)x3 copy number gain Russell-Silver syndrome [RCV003444025] Chr11:230615..8821443 [GRCh37]
Chr11:11p15.5-15.4
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4261
Count of miRNA genes:1007
Interacting mature miRNAs:1219
Transcripts:ENST00000300738, ENST00000423050, ENST00000526304, ENST00000526350, ENST00000526865, ENST00000528442, ENST00000528470, ENST00000529109, ENST00000530368, ENST00000531591, ENST00000532170, ENST00000532710, ENST00000533349, ENST00000533495, ENST00000534285, ENST00000537197
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-X59617  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37114,159,701 - 4,159,893UniSTSGRCh37
Build 36114,116,277 - 4,116,469RGDNCBI36
Celera114,164,297 - 4,164,488RGD
Cytogenetic Map11p15.5UniSTS
HuRef113,892,761 - 3,892,952UniSTS
GeneMap99-GB4 RH Map1136.62UniSTS
RH80019  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37114,147,924 - 4,148,173UniSTSGRCh37
Build 36114,104,500 - 4,104,749RGDNCBI36
Celera114,152,511 - 4,152,760RGD
Cytogenetic Map11p15.5UniSTS
HuRef113,881,238 - 3,881,487UniSTS
GDB:197861  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37114,159,687 - 4,159,936UniSTSGRCh37
Build 36114,116,263 - 4,116,512RGDNCBI36
Celera114,164,283 - 4,164,531RGD
Cytogenetic Map11p15.5UniSTS
HuRef113,892,747 - 3,892,995UniSTS
RH35854  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37114,114,206 - 4,114,359UniSTSGRCh37
Build 36114,070,782 - 4,070,935RGDNCBI36
Celera114,119,162 - 4,119,315RGD
Cytogenetic Map11p15.5UniSTS
HuRef113,847,627 - 3,847,780UniSTS
GeneMap99-GB4 RH Map1136.32UniSTS
MARC_11583-11584:1002656974:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37114,142,908 - 4,143,416UniSTSGRCh37
Build 36114,099,484 - 4,099,992RGDNCBI36
Celera114,147,498 - 4,148,006RGD
HuRef113,876,226 - 3,876,734UniSTS
RRMI  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11p15.5UniSTS
GeneMap99-GB4 RH Map1138.68UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2238 1725 1348 345 1252 190 4314 1747 2029 319 1420 1561 171 1 1178 2746 5
Low 201 1258 378 279 693 275 43 448 1705 100 39 52 4 26 42 1 2
Below cutoff 8 6 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC015689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF107045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF391285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK222786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF681281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM464333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP229960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ775841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB853003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L10342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000300738   ⟹   ENSP00000300738
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,799 - 4,138,932 (+)Ensembl
RefSeq Acc Id: ENST00000526304
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,119,062 - 4,123,270 (+)Ensembl
RefSeq Acc Id: ENST00000526350
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,852 - 4,107,570 (+)Ensembl
RefSeq Acc Id: ENST00000526865
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,805 - 4,106,147 (+)Ensembl
RefSeq Acc Id: ENST00000528442   ⟹   ENSP00000432555
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,111,975 - 4,123,384 (+)Ensembl
RefSeq Acc Id: ENST00000528470
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,119,069 - 4,123,271 (+)Ensembl
RefSeq Acc Id: ENST00000529109
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,122,109 - 4,126,817 (+)Ensembl
RefSeq Acc Id: ENST00000530368
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,101,928 - 4,106,223 (+)Ensembl
RefSeq Acc Id: ENST00000531591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,121,675 - 4,126,949 (+)Ensembl
RefSeq Acc Id: ENST00000532170   ⟹   ENSP00000435656
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,799 - 4,138,870 (+)Ensembl
RefSeq Acc Id: ENST00000532710
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,707 - 4,107,480 (+)Ensembl
RefSeq Acc Id: ENST00000533349   ⟹   ENSP00000434069
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,094,843 - 4,138,875 (+)Ensembl
RefSeq Acc Id: ENST00000533495   ⟹   ENSP00000436377
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,116,243 - 4,138,875 (+)Ensembl
RefSeq Acc Id: ENST00000534285   ⟹   ENSP00000431464
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl114,116,078 - 4,138,446 (+)Ensembl
RefSeq Acc Id: NM_001033   ⟹   NP_001024
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38114,094,799 - 4,138,932 (+)NCBI
GRCh37114,115,791 - 4,160,116 (+)NCBI
Build 36114,072,500 - 4,116,682 (+)NCBI Archive
HuRef113,849,345 - 3,893,165 (+)ENTREZGENE
CHM1_1114,115,382 - 4,159,610 (+)NCBI
T2T-CHM13v2.0114,160,064 - 4,204,024 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318064   ⟹   NP_001304993
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38114,094,685 - 4,138,925 (+)NCBI
CHM1_1114,115,382 - 4,159,610 (+)NCBI
T2T-CHM13v2.0114,159,950 - 4,204,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001318065   ⟹   NP_001304994
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38114,116,078 - 4,138,925 (+)NCBI
CHM1_1114,136,755 - 4,159,610 (+)NCBI
T2T-CHM13v2.0114,181,332 - 4,204,017 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001330193   ⟹   NP_001317122
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38114,116,078 - 4,138,925 (+)NCBI
T2T-CHM13v2.0114,181,332 - 4,204,017 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001024   ⟸   NM_001033
- Peptide Label: isoform 1
- UniProtKB: Q9UNN2 (UniProtKB/Swiss-Prot),   P23921 (UniProtKB/Swiss-Prot),   Q53GZ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304993   ⟸   NM_001318064
- Peptide Label: isoform 2
- UniProtKB: B4E0I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304994   ⟸   NM_001318065
- Peptide Label: isoform 3
- UniProtKB: B4DXD1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317122   ⟸   NM_001330193
- Peptide Label: isoform 4
- UniProtKB: E9PL69 (UniProtKB/TrEMBL),   B4DXB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000435656   ⟸   ENST00000532170
RefSeq Acc Id: ENSP00000434069   ⟸   ENST00000533349
RefSeq Acc Id: ENSP00000436377   ⟸   ENST00000533495
RefSeq Acc Id: ENSP00000431464   ⟸   ENST00000534285
RefSeq Acc Id: ENSP00000300738   ⟸   ENST00000300738
RefSeq Acc Id: ENSP00000432555   ⟸   ENST00000528442
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23921-F1-model_v2 AlphaFold P23921 1-792 view protein structure

Promoters
RGD ID:6789335
Promoter ID:HG_KWN:12083
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001033,   UC009YEH.1,   UC009YEI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36114,072,336 - 4,072,836 (+)MPROMDB
RGD ID:7219419
Promoter ID:EPDNEW_H15454
Type:initiation region
Name:RRM1_1
Description:ribonucleotide reductase catalytic subunit M1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38114,094,805 - 4,094,865EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10451 AgrOrtholog
COSMIC RRM1 COSMIC
Ensembl Genes ENSG00000167325 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000300738 ENTREZGENE
  ENST00000300738.10 UniProtKB/Swiss-Prot
  ENST00000528442.5 UniProtKB/TrEMBL
  ENST00000532170.5 UniProtKB/TrEMBL
  ENST00000533349.5 UniProtKB/TrEMBL
  ENST00000533495.5 UniProtKB/TrEMBL
  ENST00000534285 ENTREZGENE
  ENST00000534285.5 UniProtKB/TrEMBL
Gene3D-CATH 3.20.70.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000167325 GTEx
HGNC ID HGNC:10451 ENTREZGENE
Human Proteome Map RRM1 Human Proteome Map
InterPro ATP-cone_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NrdE_NrdA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNR_lg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNR_lsu_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNR_R1-su_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rrm1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6240 UniProtKB/Swiss-Prot
NCBI Gene 6240 ENTREZGENE
OMIM 180410 OMIM
PANTHER PTHR11573 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-cone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribonuc_red_lgC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribonuc_red_lgN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA298 PharmGKB, RGD
PRINTS RIBORDTASEM1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATP_CONE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  RIBORED_LARGE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PFL-like glycyl radical enzymes UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DXB0 ENTREZGENE, UniProtKB/TrEMBL
  B4DXD1 ENTREZGENE, UniProtKB/TrEMBL
  B4E0I8 ENTREZGENE, UniProtKB/TrEMBL
  E9PJ62_HUMAN UniProtKB/TrEMBL
  E9PL69 ENTREZGENE, UniProtKB/TrEMBL
  E9PP77_HUMAN UniProtKB/TrEMBL
  E9PRY9_HUMAN UniProtKB/TrEMBL
  H0YCY7_HUMAN UniProtKB/TrEMBL
  P23921 ENTREZGENE
  Q53GZ5 ENTREZGENE, UniProtKB/TrEMBL
  Q9UNN2 ENTREZGENE
  RIR1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q9UNN2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 RRM1  ribonucleotide reductase catalytic subunit M1  RRM1  ribonucleotide reductase M1  Symbol and/or name change 5135510 APPROVED