RRM1 (ribonucleotide reductase catalytic subunit M1)

Gene: RRM1 (ribonucleotide reductase catalytic subunit M1) Canis lupus familiaris

Analyze

Symbol:

RRM1

Name:

ribonucleotide reductase catalytic subunit M1

RGD ID:

12155807

Description:

ENCODES a protein that exhibits ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (ortholog); INVOLVED IN cell proliferation in forebrain (ortholog); male gonad development (ortholog); pyrimidine nucleobase metabolic process (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH adrenocortical carcinoma (ortholog); Animal Disease Models (ortholog); Autosomal Recessive Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions 6 (ortholog); FOUND IN cell projection (ortholog); neuronal cell body (ortholog); nuclear envelope (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC111091537; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase M1 polypeptide; uncharacterized LOC111091537

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	26,595,838 - 26,631,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	26,595,914 - 26,631,135 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	26,365,162 - 26,400,602 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,805,233 - 26,840,936 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,805,323 - 26,840,930 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	26,595,614 - 26,630,876 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,811,885 - 26,847,337 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,714,390 - 26,749,830 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenocortical carcinoma (ISO)

Animal Disease Models (ISO)

Autosomal Recessive Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions 6 (ISO)

delta beta-thalassemia (ISO)

Disease Progression (ISO)

Experimental Liver Neoplasms (ISO)

hepatocellular carcinoma (ISO)

lung adenocarcinoma (ISO)

lung non-small cell carcinoma (ISO)

neural tube defect (ISO)

visual epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

2'-deoxyribonucleotide biosynthetic process (IEA)

cell proliferation in forebrain (ISO)

deoxyribonucleotide biosynthetic process (IEA)

DNA repair (IEA)

male gonad development (ISO)

mitochondrial DNA replication (IEA)

positive regulation of G0 to G1 transition (IEA)

positive regulation of G1/S transition of mitotic cell cycle (IEA)

positive regulation of G2/M transition of mitotic cell cycle (IEA)

protein heterotetramerization (IEA)

pyrimidine nucleobase metabolic process (ISO)

response to ionizing radiation (ISO)

retina development in camera-type eye (ISO)

ribonucleoside diphosphate metabolic process (IEA)

Cellular Component

cell projection (ISO)

cytosol (IEA)

mitochondrion (IEA)

neuronal cell body (ISO)

nuclear envelope (ISO)

ribonucleoside-diphosphate reductase complex (IEA,ISO)

Molecular Function

ATP binding (IEA)

disordered domain specific binding (IEA)

identical protein binding (IEA)

oxidoreductase activity (IEA)

protein binding (ISO)

purine nucleotide binding (IEA)

ribonucleoside-diphosphate reductase activity (IEA)

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenine phoshoribosyltransferase deficiency pathway (ISO)

adenosine monophosphate deaminase deficiency pathway (ISO)

adenylosuccinate lyase deficiency pathway (ISO)

AICA-ribosuria pathway (ISO)

azathioprine pharmacodynamics pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

Kelley-Seegmiller syndrome pathway (ISO)

Lesch-Nyhan syndrome pathway (ISO)

mercaptopurine pharmacodynamics pathway (ISO)

molybdenum cofactor deficiency pathway (ISO)

purine metabolic pathway (ISO)

purine nucleoside phosphorylase deficiency pathway (ISO)

tioguanine pharmacodynamics pathway (ISO)

xanthinuria type I pathway (ISO)

xanthinuria pathway (ISO)

xanthinuria type II pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

RRM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	26,595,838 - 26,631,476 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	26,595,914 - 26,631,135 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	26,365,162 - 26,400,602 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	26,805,233 - 26,840,936 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	26,805,323 - 26,840,930 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	26,595,614 - 26,630,876 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	26,811,885 - 26,847,337 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	26,714,390 - 26,749,830 (+)	NCBI		UU_Cfam_GSD_1.0

RRM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	4,094,685 - 4,138,932 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	4,094,707 - 4,138,932 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	4,115,915 - 4,160,162 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	4,072,500 - 4,116,682 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	4,072,586 - 4,116,681	NCBI
Celera	11	4,120,880 - 4,164,701 (+)	NCBI		Celera
Cytogenetic Map	11	p15.4	NCBI
HuRef	11	3,849,345 - 3,893,165 (+)	NCBI		HuRef
CHM1_1	11	4,115,391 - 4,159,561 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	4,159,950 - 4,204,024 (+)	NCBI		T2T-CHM13v2.0

Rrm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	102,090,902 - 102,118,978 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	102,090,902 - 102,118,978 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	102,441,695 - 102,469,771 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	102,441,695 - 102,469,771 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	109,590,209 - 109,618,285 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	102,315,688 - 102,342,747 (+)	NCBI		MGSCv36	mm8
Celera	7	102,809,638 - 102,837,567 (+)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	54.72	NCBI

Rrm1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	166,235,904 - 166,260,206 (+)	NCBI		GRCr8
mRatBN7.2	1	156,823,960 - 156,848,262 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	156,823,960 - 156,848,261 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	164,801,707 - 164,826,040 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	171,981,799 - 172,006,127 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	164,859,508 - 164,883,799 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	167,538,387 - 167,562,688 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	167,538,263 - 167,562,688 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	173,726,994 - 173,751,295 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	159,930,994 - 159,937,860 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	154,890,871 - 154,915,173 (+)	NCBI		Celera
Cytogenetic Map	1	q32	NCBI

Rrm1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	19,850,530 - 19,905,266 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	19,850,523 - 19,904,879 (+)	NCBI	ChiLan1.0	ChiLan1.0

RRM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	6,348,683 - 6,392,806 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	5,588,407 - 5,632,547 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	3,956,528 - 3,999,205 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	4,068,119 - 4,110,474 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	4,068,119 - 4,110,474 (+)	Ensembl	panpan1.1		panPan2

Rrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	59,215,865 - 59,249,179 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936498	815,399 - 848,793 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936498	815,401 - 848,749 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	6,025,073 - 6,065,143 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	6,026,151 - 6,065,211 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	6,818,979 - 6,880,069 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RRM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	62,606,112 - 62,649,979 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	62,604,486 - 62,650,200 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666043	63,252,138 - 63,296,602 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rrm1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624817	5,523,665 - 5,568,994 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624817	5,523,648 - 5,568,997 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in RRM1
415 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	4		16		5		6		12	8	10	5
Low	1	5	6	6	1	6		6				1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_038430299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038430300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038456349	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038505640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038505641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038568834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038568835	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038633003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038633004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_534027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000009652 ⟹ ENSCAFP00000008963

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	21	26,595,914 - 26,631,135 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845020658 ⟹ ENSCAFP00845016204

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	21	26,805,323 - 26,840,930 (+)	Ensembl

RefSeq Acc Id:

XM_038430299 ⟹ XP_038286227

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	21	26,805,233 - 26,840,936 (+)	NCBI

RefSeq Acc Id:

XM_038430300 ⟹ XP_038286228

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	21	26,807,687 - 26,840,936 (+)	NCBI

RefSeq Acc Id:

XM_038456349 ⟹ XP_038312277

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	21	26,367,616 - 26,400,602 (+)	NCBI

RefSeq Acc Id:

XM_038505640 ⟹ XP_038361568

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	21	26,595,614 - 26,630,876 (+)	NCBI

RefSeq Acc Id:

XM_038505641 ⟹ XP_038361569

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	21	26,598,066 - 26,630,876 (+)	NCBI

RefSeq Acc Id:

XM_038568834 ⟹ XP_038424762

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	21	26,714,390 - 26,749,830 (+)	NCBI

RefSeq Acc Id:

XM_038568835 ⟹ XP_038424763

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	21	26,716,843 - 26,749,830 (+)	NCBI

RefSeq Acc Id:

XM_038633003 ⟹ XP_038488931

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	21	26,811,885 - 26,847,337 (+)	NCBI

RefSeq Acc Id:

XM_038633004 ⟹ XP_038488932

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	21	26,814,338 - 26,847,337 (+)	NCBI

RefSeq Acc Id:

XM_534027 ⟹ XP_534027

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	21	26,595,838 - 26,631,476 (+)	NCBI
Dog10K_Boxer_Tasha	21	26,365,162 - 26,400,602 (+)	NCBI

Sequence:

show sequence

CGAGGCGCTGGCGGCGTCGGGTAACGTCATTCGAGCTCCGTCGCGCCGCTTTTGCGCGGCTTTT
GCGTCTCGGGTGGCGGGAGCGGGAAGGGGATTCGGATTGTCGCGCCTCCGCTCGGTGGAGGAAA
GTGCCCTCTGGCCCCCAAATCAGTCCTTGCACCTGAGCACCCCCGGGAACCGGACCCTTCGCAC
TCTACCTACCACCTTCTCGATCCCGCCGGCGCCTCGGAATTGCAGCCCCGTCTCGATTCCCTCA
GCGCCTCAGCCACTAGCCGCGATGCACGTGATCAAGCGAGATGGCCGCCAAGAGCGGGTTATGT
TTGACAAAATTACATCTCGAATCCAGAAGCTATGTTATGGACTTAATATGGATTTTGTTGATCC
TGCTCAGATCACCATGAAAGTAATCCAAGGCTTATACAGTGGGGTCACTACTGTGGAACTGGAT
ACTTTGGCTGCTGAGACAGCTGCAACCTTGACGACTAAGCATCCTGACTATGCCATCCTGGCAG
CAAGGATTGCCGTCTCCAACTTGCACAAAGAAACAAAGAAAGTGTTCAGTGATGTGATGGAAGA
TCTCTACAATTACATAAATCCACATAATGGCAGACATTCTCCCATGGTGGCCAAGTCAACACTG
GATATTGTTTTGGCCAATAAAGATCGCCTGAACTCTGCCATTATCTATGACCGAGATTTCTCTT
ACAATTACTTTGGATTTAAGACACTGGAGCGGTCCTATTTGTTGAAGATCAATGGAAAAGTGGC
AGAAAGACCACAACATATGTTGATGAGAGTGTCTGTGGGGATTCACGAAGAAGATATTGATGCT
GCTATTGAAACATACAACCTTCTTTCTGAGAAGTGGTTTACCCATGCCTCTCCCACTCTGTTTA
ATGCTGGTACCAACCGCCCACAGCTTTCTAGCTGTTTCCTTCTGAGTATGAAAGATGATAGTAT
TGAAGGCATTTATGACACTCTAAAGCAGTGTGCATTGATTTCCAAGTCTGCTGGAGGAATTGGT
GTTGCTGTGAGTTGCATTCGAGCTACTGGCAGCTACATTGCTGGGACTAACGGCAACTCCAATG
GCCTTGTACCAATGCTGAGAGTATATAACAACACAGCTCGATATGTGGATCAAGGTGGAAACAA
GCGACCTGGGGCATTTGCTATTTACCTGGAACCTTGGCATTTAGACATTTTTGAGTTTCTTGAT
TTAAAGAAGAACACGGGAAAGGAAGAACAGCGTGCCAGGGACCTTTTCTTTGCTCTTTGGATTC
CAGATCTGTTCATGAAACGAGTGGAGACTAATCAGGACTGGTCTTTGATGTGTCCAAATGAATG
TCCTGGATTGGATGAGGTTTGGGGAGAGGAATTTGAAAAGCTATATGAAAGTTATGAGAAACAG
GGTCGTGTCCGCAAAGTTGTAAAAGCTCAACAGCTTTGGTATGCCATCATTGAGTCTCAGACAG
AGACAGGTACCCCGTACATGCTCTACAAAGATTCCTGTAATCGGAAAAGCAACCAGCAGAACTT
GGGAACGATCAAATGCAGCAACCTGTGCACAGAAATAGTAGAGTATACCAGCAAAGATGAGGTT
GCAGTCTGTAACTTGGCTTCCCTGGCCCTGAATATGTATGTTACATCAGAACACACATACGATT
TTAAGAAGCTGGCTGAAGTCACCAAAGTCATTGTCCGAAACTTGAATAAAATTATTGATATTAA
CTATTACCCTGTCCCAGAGGCATGCTTATCAAATAAACGCCATCGCCCCATTGGAATTGGGGTA
CAAGGTCTGGCAGATGCTTTTATTCTGATGAGGTATCCTTTTGAGAGTCCAGAAGCCCAGCTAC
TGAATAAGCAAATCTTTGAAACCATTTATTATGGAGCCTTGGAGGCCAGCTGTGACCTGGCCAA
GGAGCATGGGCCATATGAAACCTATGAAGGTTCTCCAGTCAGCAGAGGAATCCTTCAGTATGAT
ATGTGGAATGTTACTCCCACAGAACTATGGGACTGGAAACTTCTCAAGGAAAAGATTGCAAAGT
ATGGTGTAAGAAACAGTTTACTTATTGCCCCAATGCCTACTGCTTCAACTGCTCAGATTCTGGG
AAATAATGAGTCCATTGAACCTTATACCAGCAACATCTATACTCGAAGAGTCTTATCAGGAGAA
TTTCAGATTGTGAATCCTCACTTACTAAAGGATCTTACTGAGCGGGGCTTGTGGAATGAAGAGA
TGAAAAATCAGATTATTGCATGCAATGGTTCTATCCAGAGCATTCCAGAAATCCCTGATGACCT
GAAGCAACTTTATAAGACTGTGTGGGAAATTTCCCAGAAAATCGTTCTTAAGATGGCAGCTGAA
AGAGGCGCTTTCATTGATCAAAGCCAGTCTTTGAACATCCACATTGCTGAGCCTAACTATGGCA
AACTCACCAGTATGCACTTCTATGGCTGGAAGCAGGGTTTGAAGACTGGGATGTATTACTTAAG
GACACGACCAGCAGCAAATCCAATCCAGTTCACTCTAAATAAGGAGAAGCTGAAAGATAAGGAG
AAGGCAACAAAAGAAGAAGAAGAGAAGGAAAGGAACACAGCAGCCATGGTGTGCTCTTTGGAGA
ATAGAGAGGAGTGTCTGATGTGTGGGTCCTGAGGAAAGGCTTAGAAGAGACCAGCACTTCTTCA
CAGACAAACTACTTCTTGAGCATAGATAGGCATTGTAGGTTTGTTTGAAGTGCTAAGGCTTTGC
TGGATCTCATTGCAGCAAAAGGATCAGTCAATTTAAGGATCAGTCAATTTAAAGTACTGTTTCT
ATATAGTGTGAAAGTATTGATTTTAAAAATTGGTATTTTGGGAATCAAAGTAGAAGTTTTAGGA
GTGCAAAACAAGTCACCTTGCAAATAAGGAATGATTGAGTAGGGTTTCATTGCCCACCTGGCAC
CCCTTTTCTGGTGACCTCAGTTTTCATAAGGAGACATGGTTTTGCTGCTTTGACTGGTGAGTCC
ATAGACGCAAAACTGAGTCCTAACCTGTGAGAAGTGCTGATAGGACCTTTCTCTGGATAAGGTC
CTATAGGTCATTCTGAAATAAACATTTCTAAGTGATTGTGTGAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_038286227	(Get FASTA)	NCBI Sequence Viewer
	XP_038286228	(Get FASTA)	NCBI Sequence Viewer
	XP_038312277	(Get FASTA)	NCBI Sequence Viewer
	XP_038361568	(Get FASTA)	NCBI Sequence Viewer
	XP_038361569	(Get FASTA)	NCBI Sequence Viewer
	XP_038424762	(Get FASTA)	NCBI Sequence Viewer
	XP_038424763	(Get FASTA)	NCBI Sequence Viewer
	XP_038488931	(Get FASTA)	NCBI Sequence Viewer
	XP_038488932	(Get FASTA)	NCBI Sequence Viewer
	XP_534027	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000008963.4
	ENSCAFP00030031460.1
	ENSCAFP00040036262.1
	ENSCAFP00845016204
	ENSCAFP00845016204.1

RefSeq Acc Id:	XP_534027 ⟸ XM_534027
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0RNZ0 (UniProtKB/TrEMBL), A0A8I3RYN5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETA ATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVAKSTLDIVLANK DRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHEEDIDAAIETYNL LSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIR ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGK EEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVV KAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLAS LALNMYVTSEHTYDFKKLAEVTKVIVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAF ILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEHGPYETYEGSPVSRGILQYDMWNVTPT ELWDWKLLKEKIAKYGVRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPH LLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKIVLKMAAERGAFIDQ SQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKATKEEE EKERNTAAMVCSLENREECLMCGS hide sequence

RefSeq Acc Id:

ENSCAFP00000008963 ⟸ ENSCAFT00000009652

RefSeq Acc Id:	XP_038361568 ⟸ XM_038505640
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038361569 ⟸ XM_038505641
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038488931 ⟸ XM_038633003
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038488932 ⟸ XM_038633004
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038286227 ⟸ XM_038430299
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0RNZ0 (UniProtKB/TrEMBL), A0A8I3RYN5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038286228 ⟸ XM_038430300
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038312277 ⟸ XM_038456349
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038424762 ⟸ XM_038568834
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0RNZ0 (UniProtKB/TrEMBL), A0A8I3RYN5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038424763 ⟸ XM_038568835
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSCAFP00845016204 ⟸ ENSCAFT00845020658

Protein Domains

ATP-cone

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000005945	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030019618	UniProtKB/TrEMBL
	ENSCAFG00040022377	UniProtKB/TrEMBL
	ENSCAFG00845011642	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000009652.6	UniProtKB/TrEMBL
	ENSCAFT00030036066.1	UniProtKB/TrEMBL
	ENSCAFT00040041567.1	UniProtKB/TrEMBL
	ENSCAFT00845020658	ENTREZGENE
	ENSCAFT00845020658.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.70.20	UniProtKB/TrEMBL
InterPro	ATP-cone_dom	UniProtKB/TrEMBL
	NrdE_NrdA	UniProtKB/TrEMBL
	RNR_lg_C	UniProtKB/TrEMBL
	RNR_lsu_N	UniProtKB/TrEMBL
	RNR_R1-su_N	UniProtKB/TrEMBL
	Rrm1	UniProtKB/TrEMBL
NCBI Gene	RRM1	ENTREZGENE
PANTHER	PTHR11573	UniProtKB/TrEMBL
	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT	UniProtKB/TrEMBL
Pfam	ATP-cone	UniProtKB/TrEMBL
	Ribonuc_red_lgC	UniProtKB/TrEMBL
	Ribonuc_red_lgN	UniProtKB/TrEMBL
PRINTS	RIBORDTASEM1	UniProtKB/TrEMBL
PROSITE	ATP_CONE	UniProtKB/TrEMBL
	RIBORED_LARGE	UniProtKB/TrEMBL
Superfamily-SCOP	PFL-like glycyl radical enzymes	UniProtKB/TrEMBL
	SSF48168	UniProtKB/TrEMBL
UniProt	A0A8C0RNZ0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RYN5	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:45760	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-01-14	RRM1	ribonucleotide reductase catalytic subunit M1	LOC111091537	uncharacterized LOC111091537	Data merged from RGD:13311140	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB