Spag4 (sperm associated antigen 4)

Gene: Spag4 (sperm associated antigen 4) Mus musculus

Analyze

Symbol:

Spag4

Name:

sperm associated antigen 4

RGD ID:

734256

MGI Page

MGI

Description:

Predicted to enable identical protein binding activity and protein-membrane adaptor activity. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in microtubule. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Is expressed in brainstem; genitourinary system; submandibular gland; and trachea. Orthologous to human SPAG4 (sperm associated antigen 4).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1700041K21Rik; KIAA4118; MGC130280; mKIAA4118; MNCb-0953; outer dense fiber-associated protein SPAG4; sperm antigen 4; sperm-associated antigen 4 protein; Su; SUN domain-containing protein 4; Sun4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPAG4 (sperm associated antigen 4)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Spag4 (sperm associated antigen 4)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Spag4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SPAG4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPAG4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spag4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPAG4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPAG4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spag4 (sperm associated antigen 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Spag4 (sperm associated antigen 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SPAG4 (sperm associated antigen 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	unc-84	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	spag4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,907,108 - 155,911,421 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	155,907,095 - 155,912,537 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	156,065,188 - 156,069,501 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	156,065,175 - 156,070,617 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	155,890,949 - 155,895,235 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	155,756,668 - 155,760,665 (+)	NCBI		MGSCv36	mm8
Celera	2	162,000,620 - 162,004,906 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

all-trans-retinoic acid (EXP,ISO)

ammonium chloride (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

choline (EXP)

cobalt dichloride (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

flavonoids (ISO)

folic acid (EXP)

glycidol (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (EXP)

mercury dibromide (ISO)

methamphetamine (EXP)

nickel dichloride (ISO)

paracetamol (ISO)

phenylmercury acetate (ISO)

pirinixic acid (EXP)

quercetin (ISO)

quinolin-8-ol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

Soman (ISO)

testosterone (ISO)

thimerosal (ISO)

trichloroethene (ISO)

tris(2-butoxyethyl) phosphate (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

spermatogenesis (IEA)

Cellular Component

cell projection (IEA)

cilium (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

meiotic nuclear membrane microtubule tethering complex (IBA)

membrane (IEA)

microtubule (ISO)

motile cilium (IEA)

nuclear envelope (IBA)

nucleus (IEA)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

protein-membrane adaptor activity (IBA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal acrosome morphology (IAGP)

abnormal epididymis morphology (IAGP)

abnormal manchette assembly (IAGP)

abnormal manchette morphology (IAGP)

abnormal outer dense fiber morphology (IAGP)

abnormal sperm connecting piece morphology (IAGP)

abnormal sperm head morphology (IAGP)

abnormal sperm nucleus morphology (IAGP)

abnormal sperm principal piece morphology (IAGP)

abnormal spermatid morphology (IAGP)

abnormal spermiogenesis (IAGP)

absent manchette (IAGP)

coiled sperm flagellum (IAGP)

detached acrosome (IAGP)

ectopic manchette (IAGP)

globozoospermia (IAGP)

hyperactivity (IEA)

increased fasting circulating glucose level (IEA)

male infertility (IAGP)

oligozoospermia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Electronic Transfer of Homolog Data	MGD and Homologene mouse data transfer
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Database resources of the National Center for Biotechnology Information.	Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.

Additional References at PubMed

PMID:10349636	PMID:10373309	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12477932	PMID:14610273	PMID:15489334	PMID:16141072	PMID:16141073	PMID:21873635	PMID:24194600
PMID:26417726	PMID:26621829	PMID:28378742	PMID:28700664	PMID:29663073	PMID:36825599

Genomics

Comparative Map Data

Spag4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	155,907,108 - 155,911,421 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	155,907,095 - 155,912,537 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	156,065,188 - 156,069,501 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	156,065,175 - 156,070,617 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	155,890,949 - 155,895,235 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	155,756,668 - 155,760,665 (+)	NCBI		MGSCv36	mm8
Celera	2	162,000,620 - 162,004,906 (+)	NCBI		Celera
Cytogenetic Map	2	H1	NCBI
cM Map	2	77.34	NCBI

SPAG4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	35,615,829 - 35,621,094 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	35,615,829 - 35,621,094 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	34,203,751 - 34,209,016 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	33,667,223 - 33,672,379 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	33,667,222 - 33,672,379	NCBI
Celera	20	30,952,104 - 30,957,260 (+)	NCBI		Celera
Cytogenetic Map	20	q11.22	NCBI
HuRef	20	30,981,190 - 30,986,346 (+)	NCBI		HuRef
CHM1_1	20	34,105,451 - 34,110,607 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	37,336,805 - 37,342,070 (+)	NCBI		T2T-CHM13v2.0

Spag4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	165,040,682 - 165,047,963 (+)	NCBI		GRCr8
mRatBN7.2	3	144,581,006 - 144,587,879 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	144,581,095 - 144,585,435 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	148,446,861 - 148,451,205 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	157,064,133 - 157,068,477 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	154,803,659 - 154,808,003 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	151,609,602 - 151,613,946 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	151,609,602 - 151,613,942 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	157,974,080 - 157,978,564 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	146,472,609 - 146,476,953 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	143,302,863 - 143,307,207 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Spag4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	25,840,498 - 25,845,299 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	25,840,302 - 25,844,787 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPAG4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	41,346,363 - 41,356,059 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	41,338,265 - 41,349,623 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	31,941,094 - 31,947,725 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	33,059,296 - 33,064,429 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	33,059,302 - 33,064,429 (+)	Ensembl	panpan1.1		panPan2

SPAG4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	24,547,312 - 24,565,770 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	24,547,488 - 24,551,700 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	24,192,477 - 24,210,910 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	25,239,948 - 25,258,368 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	25,240,077 - 25,244,289 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	24,526,323 - 24,532,457 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	24,621,303 - 24,639,728 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	25,060,729 - 25,079,155 (+)	NCBI		UU_Cfam_GSD_1.0

Spag4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	173,541,234 - 173,546,088 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936561	5,204,062 - 5,208,189 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936561	5,203,476 - 5,208,265 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPAG4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	38,947,718 - 38,954,115 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	38,947,352 - 38,952,363 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	44,276,510 - 44,281,339 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPAG4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	56,542,715 - 56,548,465 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	56,543,061 - 56,548,438 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666087	2,884,674 - 2,890,404 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spag4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624842	3,824,411 - 3,828,413 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Spag4
209 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1428
Count of miRNA genes:	568
Interacting mature miRNAs:	700
Transcripts:	ENSMUST00000038860, ENSMUST00000125996, ENSMUST00000131144, ENSMUST00000133511, ENSMUST00000136765, ENSMUST00000137966, ENSMUST00000138178, ENSMUST00000149139
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
5491197	Mobq5_m	multigenic obesity QTL 5 (mouse)			Not determined		2	65269746	162518926	Mouse
5491196	Mobq6_m	multigenic obesity QTL 6 (mouse)			Not determined		2	85724269	180896594	Mouse
27226788	Feml13_m	femur length 13, 10 week (mouse)					2	102630345	159941920	Mouse
11038702	Ltpr2_m	Leishmania tropica response 2 (mouse)					2	103095716	167212356	Mouse
1301618	Bglu1_m	blood glucose level 1 (mouse)			Not determined		2	117942930	174324863	Mouse
12910795	Pwbwq5_m	post-weaning body weight QTL 5 (mouse)					2	118589253	160611165	Mouse
12910799	Pwgrq2_m	pre-weaning growth rate QTL 2 (mouse)					2	118589253	160611165	Mouse
12910812	Pwgrq1_m	pre-weaning growth rate QTL 1 (mouse)					2	118589253	160611165	Mouse
12910814	Pwbwq1_m	pre-weaning body weight QTL 1 (mouse)					2	118589253	160611165	Mouse
1301294	Hrtfm5_m	heart failure modifier 5 (mouse)			Not determined		2	122883015	156883131	Mouse
1301822	Pgia2_m	proteoglycan induced arthritis 2 (mouse)			Not determined		2	123937311	157937424	Mouse
27226749	Femd10_m	femur midshaft diameter 10, 16 week (mouse)					2	124441920	168241920	Mouse
1302143	Bwq5_m	body weight (mouse)			Not determined		2	127664019	161664118	Mouse
1301031	Bdln3_m	body length 3 (mouse)			Not determined		2	127664019	161664118	Mouse
12880427	V25Dq3_m	vitamin D inactive form serum level QTL 3 (mouse)					2	129341920	163341920	Mouse
1301961	Bts1_m	bladder tumor susceptibility 1 (mouse)			Not determined		2	132024159	166024330	Mouse
11049567	Lmr28f_m	leishmaniasis resistance 28f (mouse)					2	133144911	167145058	Mouse
11049566	Lmr28e_m	leishmaniasis resistance 28e (mouse)					2	133144911	167145058	Mouse
11341717	Rvfs1_m	Rift Valley fever susceptibility 1 (mouse)					2	135432544	173449616	Mouse
4141703	Chlq13_m	circulating hormone level QTL 13 (mouse)			Not determined		2	135699221	169699361	Mouse
1301907	Rends_m	renal disease susceptibility (mouse)			Not determined		2	135699221	169699361	Mouse
10043956	Gnf5_m	growth and fatness 5 (mouse)			Not determined		2	135699221	169699361	Mouse
10054066	Bwq9_m	body weight QTL 9 (mouse)			Not determined		2	135699221	169699361	Mouse
1300846	Pbwg11_m	postnatal body weight growth 11 (mouse)			Not determined		2	138966600	172966729	Mouse
11353826	Bdln10_m	body length 10 (mouse)					2	140441482	174441482	Mouse
12801461	Intim1_m	intima modifier 1 (mouse)					2	142428347	176428450	Mouse
12801456	Intmrm1_m	intima/media ratio modifier 1 (mouse)					2	142428347	176428450	Mouse
1301783	Bhr1_m	bronchial hyperresponsiveness 1 (mouse)			Not determined		2	142593476	178442452	Mouse
4141033	Wg2d_m	weight gain in high growth mice 2d (mouse)			Not determined			143773445	160303008	Mouse
1357484	Bsbob_m	BSB obesity (mouse)			Not determined		2	143773445	165665019	Mouse
1558939	Gnf1_m	growth and fatness 1 (mouse)			Not determined		2	143773445	169117924	Mouse
1300867	Lore2_m	loss of righting induced by ethanol 2 (mouse)			Not determined		2	144515861	180896594	Mouse
1302013	Tbbmd3_m	total body bone mineral density 3 (mouse)			Not determined		2	145196949	179197085	Mouse
1300806	Aod4_m	autoimmune ovarian dysgenesis 4 (mouse)			Not determined		2	145228719	179228841	Mouse
1301865	Hdlq19_m	HDL QTL 19 (mouse)			Not determined		2	145518775	179518926	Mouse
13504830	Bacsq1_m	baculum shape QTL 1 (mouse)					2	145716184	161016184	Mouse
12790983	Bwq12_m	body weight QTL 12 (mouse)					2	148238204	181755017	Mouse
4142211	Nilac3_m	nicotine induced locomotor activity 3 (mouse)			Not determined		2	148664893	181755017	Mouse
1558917	Gct8_m	granulosa cell tumorigenesis 8 (mouse)			Not determined		2	149236907	181755017	Mouse
1300751	Bdt1_m	bone density traits 1 (mouse)			Not determined		2	149988902	181755017	Mouse
1301085	Lrnx10_m	learning-contextual 10 (mouse)			Not determined		2	150212221	181755017	Mouse
11038701	Ltpr2e_m	Leishmania tropica response 2e (mouse)					2	150212221	181755017	Mouse
4142450	Lmr16_m	leishmaniasis resistance 16 (mouse)			Not determined		2	150212221	181755017	Mouse
1357862	Epfq1_m	epididymal fat pad weight QTL 1 (mouse)			Not determined		2	151640941	162737074	Mouse
1357772	Scfq1_m	subcutaneous fat pad weight QTL 1 (mouse)			Not determined		2	151640941	162737074	Mouse
1558842	Tailq2_m	tail length QTL 2 (mouse)			Not determined		2	151640941	162737074	Mouse
10412080	Hylaq2_m	Hyperlocomotor activity related QTL 2 (mouse)			Not determined		2	151640941	164119146	Mouse
12910520	Scgq3_m	spontaneous crescentic glomerulonephritis QTL 3 (mouse)					2	151709273	174389124	Mouse
1301019	Bmd6_m	bone mineral density 6 (mouse)			Not determined		2	151778297	181755017	Mouse
13825247	Agoc2_m	agouti coat color QTL 2 (mouse)					2	151841920	159841920	Mouse
14747002	Mancz3_m	mandible centroid size 3 (mouse)					2	152329820	181755017	Mouse
1558852	Gnf2_m	growth and fatness 2 (mouse)			Not determined		2	152699221	162197085	Mouse
1558867	Gnf3_m	growth and fatness 3 (mouse)			Not determined		2	152699221	169117924	Mouse
13524521	Bodwtq2_m	body wweight QTL 2 (mouse)					2	153456184	156386184	Mouse
1301588	Hrec_m	hemotopoietic response to early cytokines (mouse)			Not determined		2	154553217	159428450	Mouse
1300622	Cfld1_m	cystic fibrosis lung disease 1 (mouse)			Not determined		2	155823920	181755017	Mouse

Markers in Region

UniSTS:487762

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	2	156,065,314 - 156,066,830	UniSTS	GRCm38
MGSCv37	2	155,891,050 - 155,892,566	UniSTS	GRCm37
Celera	2	162,000,721 - 162,002,237	UniSTS
Cytogenetic Map	2	H1	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006499540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB041554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK028080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK043812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK220494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL833786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY231113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY591699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000038860 ⟹ ENSMUSP00000036484

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,164 - 155,911,421 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,244 - 156,069,501 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000125996

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,118 - 155,912,537 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,198 - 156,070,617 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000131144 ⟹ ENSMUSP00000120079

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,473 - 155,909,448 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,553 - 156,067,528 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000133511

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,095 - 155,911,421 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,175 - 156,069,501 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000136765

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,147 - 155,911,144 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,227 - 156,069,224 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000137966 ⟹ ENSMUSP00000118715

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,662 - 155,909,970 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,742 - 156,068,050 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000138178 ⟹ ENSMUSP00000121781

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,907,357 - 155,909,242 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,065,437 - 156,067,322 (+)	Ensembl

RefSeq Acc Id:

ENSMUST00000149139

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	2	155,908,655 - 155,911,298 (+)	Ensembl
GRCm38.p6 Ensembl	2	156,066,735 - 156,069,378 (+)	Ensembl

RefSeq Acc Id:

NM_139151 ⟹ NP_631890

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	155,907,133 - 155,911,419 (+)	NCBI
GRCm38	2	156,065,213 - 156,069,499 (+)	NCBI
MGSCv37	2	155,890,949 - 155,895,235 (+)	RGD
Celera	2	162,000,620 - 162,004,906 (+)	RGD
cM Map	2		ENTREZGENE

Sequence:

show sequence

ACGGTGACAACAGCACAGCAGCGGGAGGGTCGGCCGAGCCGCCGCGGGGCTCACGCAGGGTGCT
ACCCTGCGGCGCGAGGCAGCTGAGGAAGGGCCGAGGGCTTTGGCTGCGGCGACTTCGGCTTCCC
AGAGGGGTAGCCCAGGTCAGGATGCGGCGGAGCCCCCGCTCAGGCTCGGCCGCATCCTCTCATA
ATCACACACCCAACTTCTACAGCGAGAACAGCAATAGTTCCCACAGCGCGACTTCGGGGGACAG
CAATGGGCGCCGGTCCGCTGGGCCGGAGCTCGGGGAGCCCGAGGGCAGAAGGGCCCGGGGCTCG
AGCTGTGGTGAGCCCGCCTTAAGCCCAGGAATGCCCGGAGGAGACACATGGGCAGGAAGCTCTC
GGCCGAAGCTGGCGCCTCGGAGCCACAATGGGCAGACCGCCTGTGGCGCGGCAACCGTGAGGGG
CGGGGCCTCGGAACCGTCTGGATCTTCTGTAGTTTTGGAGGAACAACTCAACCTTCTCCCGATC
CTGGATCTGAGGCAGGAGATGCCTACCCCGAGGGTGTCCAAGAGCTTCCTGAGCCTCCTCTTTC
AGGTGCTGAGCATGGTGTTATCCCTGGCAGTCGATGGGCTGGTCTGTGTGTGCAGGGAAATCTG
CTCCATCCGCTTCCTGTTCACTGCTGTGTCGCTCCTGAGCATCTTTCTGGCAGCACTCTGGTGG
GGGCTCCTGTACCTGATCCCTCCTTTGGAGAACGAACCTACGGAGATGCTGACTCTAAGCCAAT
ACCACCACCGCGTGCATTCCCAGGGCCAGCAACTGCAGCAGCTCCAGGCAGAACTGAATAAACT
CCACAAGGAGGTGTCCAGCGTTCGTGCAGCCCACAGTGAGAGAGTGGCCAAGCTCGTGTTCCAG
AGGCTGAATGAAGACTTCGTGCGCAAACCTGACTATGCACTGAGCTCTGTGGGAGCCTCCATCG
ACCTGGAGAAGACGTCCAGTGACTACGAGGACCAGAACACTGCCTACTTCTGGAACCGCTTGAG
CTTCTGGAACTATGCCCGCCCGCCTTCTGTCATATTGGAGCCAGATGTGTTCCCTGGAAATTGC
TGGGCTTTTGAAGGTGATAAAGGCCAGGTGGTGATCCGACTGCCAGGTCATGTGCAGTTAAGCG
ACATCACCCTGCAGCATCCTCCACCCACTGTGGCACACACCGGAGGGGCCAGCAGCGCGCCTCG
GGACTTTGCAGTCTATGGGCTCCAAGCTGATGACGAGACTGAAGTGTTCTTGGGGAAATTCATC
TTTGATGTGCAGAAATCTGAAATTCAGACTTTCCACCTCCAGAATGATCCTCCTTCTGCCTTCC
CCAAGGTGAAGATTCAGATTCTAAGCAACTGGGGCCATCCCCGCTTCACGTGCTTATATCGCGT
CCGTGCTCATGGTGTGCGGACCTCAGAGTGGGCAGACGATAATGCCACAGGGGTCACAGGGGGA
CCCCATTAAAAATGCCGATGGTTGGAGTAG

hide sequence

RefSeq Acc Id:

XM_006499540 ⟹ XP_006499603

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	2	155,907,108 - 155,911,421 (+)	NCBI
GRCm38	2	156,065,188 - 156,069,501 (+)	NCBI

Sequence:

show sequence

CGCTCTGTGACGCGGCTCCTCTGTGACGGTGACAACAGCACAGCAGCGGGAGGGTCGGCCGAGC
CGCCGCGGGGCTCACGCAGGGTGCTACCCTGCGGCGCGAGGCAGCTGAGGAAGGGCCGAGGGCT
TTGGCTGCGGCGACTTCGGCTTCCCAGAGGGGTAGCCCAGGTCAGGATGCGGCGGAGCCCCCGC
TCAGGCTCGGCCGCATCCTCTCATAATCACACACCCAACTTCTACAGCGAGAACAGCAATAGTT
CCCACAGCGCGACTTCGGGGGACAGCAATGGGCGCCGGTCCGCTGGGCCGGAGCTCGGGGAGCC
CGAGGGCAGAAGGGCCCGGGGCTCGAGCTGTGGTGAGCCCGCCTTAAGCCCAGGAATGCCCGGA
GGAGACACATGGGCAGGAAGCTCTCGGCCGAAGCTGGCGCCTCGGAGCCACAATGGGCAGACCG
CCTGTGGCGCGGCAACCAACCGTCTGGATCTTCTGTAGTTTTGGAGGAACAACTCAACCTTCTC
CCGATCCTGGATCTGAGGCAGGAGATGCCTACCCCGAGGGTGTCCAAGAGCTTCCTGAGCCTCC
TCTTTCAGGTGCTGAGCATGGTGTTATCCCTGGCAGTCGATGGGCTGGTCTGTGTGTGCAGGGA
AATCTGCTCCATCCGCTTCCTGTTCACTGCTGTGTCGCTCCTGAGCATCTTTCTGGCAGCACTC
TGGTGGGGGCTCCTGTACCTGATCCCTCCTTTGGAGAACGAACCTACGGAGATGCTGACTCTAA
GCCAATACCACCACCGCGTGCATTCCCAGGGCCAGCAACTGCAGCAGCTCCAGGCAGAACTGAA
TAAACTCCACAAGGAGGTGTCCAGCGTTCGTGCAGCCCACAGTGAGAGAGTGGCCAAGCTCGTG
TTCCAGAGGCTGAATGAAGACTTCGTGCGCAAACCTGACTATGCACTGAGCTCTGTGGGAGCCT
CCATCGACCTGGAGAAGACGTCCAGTGACTACGAGGACCAGAACACTGCCTACTTCTGGAACCG
CTTGAGCTTCTGGAACTATGCCCGCCCGCCTTCTGTCATATTGGAGCCAGATGTGTTCCCTGGA
AATTGCTGGGCTTTTGAAGGTGATAAAGGCCAGGTGGTGATCCGACTGCCAGGTCATGTGCAGT
TAAGCGACATCACCCTGCAGCATCCTCCACCCACTGTGGCACACACCGGAGGGGCCAGCAGCGC
GCCTCGGGACTTTGCAGTCTATGGGCTCCAAGCTGATGACGAGACTGAAGTGTTCTTGGGGAAA
TTCATCTTTGATGTGCAGAAATCTGAAATTCAGACTTTCCACCTCCAGAATGATCCTCCTTCTG
CCTTCCCCAAGGTGAAGATTCAGATTCTAAGCAACTGGGGCCATCCCCGCTTCACGTGCTTATA
TCGCGTCCGTGCTCATGGTGTGCGGACCTCAGAGTGGGCAGACGATAATGCCACAGGGGTCACA
GGGGGACCCCATTAAAAATGCCGATGGTTGGAGTAGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_631890	(Get FASTA)	NCBI Sequence Viewer
	XP_006499603	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07322	(Get FASTA)	NCBI Sequence Viewer
	BAA95039	(Get FASTA)	NCBI Sequence Viewer
	BAC31661	(Get FASTA)	NCBI Sequence Viewer
	BAD90292	(Get FASTA)	NCBI Sequence Viewer
	EDL06167	(Get FASTA)	NCBI Sequence Viewer
	EDL06168	(Get FASTA)	NCBI Sequence Viewer
	EDL06169	(Get FASTA)	NCBI Sequence Viewer
	EDL06170	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000036484
	ENSMUSP00000036484.6
	ENSMUSP00000118715.2
	ENSMUSP00000120079.2
	ENSMUSP00000121781.2
GenBank Protein	Q9JJF2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_631890 ⟸ NM_139151

- UniProtKB:

A3KGK4 (UniProtKB/Swiss-Prot), Q9JJF2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MRRSPRSGSAASSHNHTPNFYSENSNSSHSATSGDSNGRRSAGPELGEPEGRRARGSSCGEPAL
SPGMPGGDTWAGSSRPKLAPRSHNGQTACGAATVRGGASEPSGSSVVLEEQLNLLPILDLRQEM
PTPRVSKSFLSLLFQVLSMVLSLAVDGLVCVCREICSIRFLFTAVSLLSIFLAALWWGLLYLIP
PLENEPTEMLTLSQYHHRVHSQGQQLQQLQAELNKLHKEVSSVRAAHSERVAKLVFQRLNEDFV
RKPDYALSSVGASIDLEKTSSDYEDQNTAYFWNRLSFWNYARPPSVILEPDVFPGNCWAFEGDK
GQVVIRLPGHVQLSDITLQHPPPTVAHTGGASSAPRDFAVYGLQADDETEVFLGKFIFDVQKSE
IQTFHLQNDPPSAFPKVKIQILSNWGHPRFTCLYRVRAHGVRTSEWADDNATGVTGGPH

hide sequence

RefSeq Acc Id:

XP_006499603 ⟸ XM_006499540

- Peptide Label:

isoform X1

- Sequence:

show sequence

MGRKLSAEAGASEPQWADRLWRGNQPSGSSVVLEEQLNLLPILDLRQEMPTPRVSKSFLSLLFQ
VLSMVLSLAVDGLVCVCREICSIRFLFTAVSLLSIFLAALWWGLLYLIPPLENEPTEMLTLSQY
HHRVHSQGQQLQQLQAELNKLHKEVSSVRAAHSERVAKLVFQRLNEDFVRKPDYALSSVGASID
LEKTSSDYEDQNTAYFWNRLSFWNYARPPSVILEPDVFPGNCWAFEGDKGQVVIRLPGHVQLSD
ITLQHPPPTVAHTGGASSAPRDFAVYGLQADDETEVFLGKFIFDVQKSEIQTFHLQNDPPSAFP
KVKIQILSNWGHPRFTCLYRVRAHGVRTSEWADDNATGVTGGPH

hide sequence

RefSeq Acc Id:

ENSMUSP00000121781 ⟸ ENSMUST00000138178

RefSeq Acc Id:

ENSMUSP00000120079 ⟸ ENSMUST00000131144

RefSeq Acc Id:

ENSMUSP00000118715 ⟸ ENSMUST00000137966

RefSeq Acc Id:

ENSMUSP00000036484 ⟸ ENSMUST00000038860

Protein Domains

SUN

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JJF2-F1-model_v2	AlphaFold	Q9JJF2	1-443	view protein structure

Promoters

RGD ID:

6831847

Promoter ID:

MM_KWN:32593

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_0Hour, Brain, ES_Cell, Liver, MEF_B4

Transcripts:

OTTMUST00000038350, OTTMUST00000038358, OTTMUST00000038359, OTTMUST00000038361, OTTMUST00000060785, OTTMUST00000084166, OTTMUST00000084167, UC008NMB.1

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	2	155,891,071 - 155,891,642 (+)	MPROMDB

RGD ID:

6879392

Promoter ID:

EPDNEW_M3147

Type:

initiation region

Name:

Spag4_1

Description:

Mus musculus sperm associated antigen 4 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M3148

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	156,065,212 - 156,065,272	EPDNEW

RGD ID:

6879394

Promoter ID:

EPDNEW_M3148

Type:

multiple initiation site

Name:

Spag4_2

Description:

Mus musculus sperm associated antigen 4 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M3147

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	2	156,065,745 - 156,065,805	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2444120	AgrOrtholog
Ensembl Genes	ENSMUSG00000038180	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000038860	ENTREZGENE
	ENSMUST00000038860.12	UniProtKB/Swiss-Prot
	ENSMUST00000131144.8	UniProtKB/TrEMBL
	ENSMUST00000137966.2	UniProtKB/TrEMBL
	ENSMUST00000138178.8	UniProtKB/TrEMBL
Gene3D-CATH	Galactose-binding domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	SUN1-5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUN_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:245865	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:2444120	ENTREZGENE
NCBI Gene	245865	ENTREZGENE
PANTHER	PTHR12911	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12911:SF16	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Sad1_UNC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Spag4	PhenoGen
PROSITE	SUN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A3KGK4	ENTREZGENE
	B7ZCP3_MOUSE	UniProtKB/TrEMBL
	F6S430_MOUSE	UniProtKB/TrEMBL
	F6XNA5_MOUSE	UniProtKB/TrEMBL
	Q3B7Z4_MOUSE	UniProtKB/TrEMBL
	Q5DTM6_MOUSE	UniProtKB/TrEMBL
	Q8BLQ4_MOUSE	UniProtKB/TrEMBL
	Q9JJF2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	A3KGK4	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype