Pcx (pyruvate carboxylase) - Rat Genome Database

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Gene: Pcx (pyruvate carboxylase) Mus musculus
Analyze
Symbol: Pcx
Name: pyruvate carboxylase
RGD ID: 733419
MGI Page MGI
Description: Enables pyruvate carboxylase activity. Involved in gluconeogenesis. Located in mitochondrion. Is active in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: P; Pc; Pcb; pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; pyruvic carboxylase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,560,500 - 4,671,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,560,500 - 4,671,780 (+)EnsemblGRCm39 Ensembl
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBIMGSCv36mm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzatropine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP)
D-glucose  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
duvoglustat  (EXP)
elemental selenium  (ISO)
entacapone  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidyl methacrylate  (ISO)
GW 4064  (EXP)
hydrogen peroxide  (ISO)
imipramine  (ISO)
indometacin  (ISO)
inulin  (EXP)
iodide salt  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ethionine  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
mifepristone  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (ISO)
N-hexadecanoylsphingosine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (EXP,ISO)
Propiverine  (ISO)
resveratrol  (EXP)
rimonabant  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
selenic acid  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
Tesaglitazar  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
tolcapone  (ISO)
triadimefon  (ISO)
tributylstannane  (EXP)
trichloroethene  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP)
vorinostat  (ISO)
zearalenone  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver. Ballard FJ and Hanson RW, Biochem J. 1967 Sep;104(3):866-71.
2. Amerindian pyruvate carboxylase deficiency is associated with two distinct missense mutations. Carbone MA, etal., Am J Hum Genet 1998 Jun;62(6):1312-9.
3. Intron retention and frameshift mutations result in severe pyruvate carboxylase deficiency in two male siblings. Carbone MA, etal., Hum Mutat. 2002 Jul;20(1):48-56.
4. Structure, mechanism and regulation of pyruvate carboxylase. Jitrapakdee S, etal., Biochem J. 2008 Aug 1;413(3):369-87.
5. Regulation of pyruvate carboxylase activity by calcium in intact rat liver mitochondria. Kimmich GA and Rasmussen H, J Biol Chem. 1969 Jan 10;244(1):190-9.
6. Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway. Liu YQ, etal., Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E471-8. Epub 2004 Oct 26.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
Additional References at PubMed
PMID:1358795   PMID:6548474   PMID:7698008   PMID:8446588   PMID:8499657   PMID:9730611   PMID:10349636   PMID:10549128   PMID:10922068   PMID:10938127   PMID:11042159   PMID:11076861  
PMID:11167010   PMID:11217851   PMID:11554743   PMID:12477932   PMID:12865426   PMID:12904583   PMID:14610273   PMID:14681479   PMID:15489334   PMID:15782199   PMID:15917242   PMID:16141072  
PMID:16141073   PMID:16916647   PMID:17761669   PMID:18614015   PMID:18662986   PMID:18799693   PMID:19910451   PMID:20171190   PMID:21267068   PMID:21677750   PMID:21745612   PMID:21873635  
PMID:22354779   PMID:22794259   PMID:22922362   PMID:22967998   PMID:23423574   PMID:24194600   PMID:25240193   PMID:25607840   PMID:26767982   PMID:27138252   PMID:27215380   PMID:27265727  
PMID:27626380   PMID:27689697   PMID:27754788   PMID:28188211   PMID:28245920   PMID:28254784   PMID:29518331   PMID:30947518   PMID:31006591   PMID:31693883   PMID:32554809   PMID:32581705  
PMID:35237793   PMID:36417873   PMID:36441025   PMID:36653359   PMID:37225978  


Genomics

Comparative Map Data
Pcx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,560,500 - 4,671,780 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,560,500 - 4,671,780 (+)EnsemblGRCm39 Ensembl
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBIMGSCv36mm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.07NCBI
PC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381166,848,420 - 66,958,383 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1166,848,417 - 66,958,386 (-)EnsemblGRCh38hg38GRCh38
GRCh371166,615,891 - 66,725,854 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,372,573 - 66,482,423 (-)NCBINCBI36Build 36hg18NCBI36
Build 341166,372,572 - 66,431,998NCBI
Celera1163,944,403 - 64,054,124 (-)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1162,944,043 - 63,053,644 (-)NCBIHuRef
CHM1_11166,499,596 - 66,607,614 (-)NCBICHM1_1
T2T-CHM13v2.01166,844,694 - 66,952,886 (-)NCBIT2T-CHM13v2.0
Pc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,228,708 - 211,327,792 (+)NCBIGRCr8
mRatBN7.21201,799,374 - 201,898,412 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,804,267 - 201,898,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1210,152,085 - 210,251,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,244,857 - 217,343,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,935,881 - 210,034,819 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,759,157 - 219,859,854 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,759,183 - 219,859,848 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,626,831 - 226,726,350 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,112,853 - 207,212,737 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11207,266,305 - 207,366,189 (+)NCBI
Celera1199,343,224 - 199,439,273 (+)NCBICelera
RH 3.4 Map11554.4RGD
Cytogenetic Map1q43NCBI
Pc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,420,596 - 18,536,436 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,421,100 - 18,536,591 (+)NCBIChiLan1.0ChiLan1.0
PC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,074,256 - 68,186,372 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,116,844 - 69,229,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,644 - 62,317,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11165,527,285 - 65,639,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,527,662 - 65,551,396 (-)Ensemblpanpan1.1panPan2
PC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,406,994 - 50,507,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,412,272 - 50,507,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,016,958 - 49,117,517 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01851,357,399 - 51,457,857 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1851,357,414 - 51,457,857 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,541,749 - 50,642,299 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01850,121,287 - 50,221,660 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,910,958 - 51,011,409 (+)NCBIUU_Cfam_GSD_1.0
Pc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,235,346 - 6,350,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,677,583 - 2,793,197 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,677,770 - 2,793,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,518,517 - 5,587,797 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,566,608 - 5,587,797 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,594,815 - 4,609,731 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p17NCBI
PC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,310,738 - 7,418,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl17,357,246 - 7,417,998 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038104,598,850 - 104,705,939 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476719,480,522 - 19,614,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476719,481,158 - 19,601,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcx
3264 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:185
Interacting mature miRNAs:217
Transcripts:ENSMUST00000068004, ENSMUST00000113825
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001162946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006531678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA619324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK128927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG087228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY059816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY139237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY230152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY293312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L09192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M97957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000068004   ⟹   ENSMUSP00000063825
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,560,500 - 4,671,780 (+)Ensembl
GRCm38.p6 Ensembl194,510,472 - 4,621,752 (+)Ensembl
RefSeq Acc Id: ENSMUST00000113825   ⟹   ENSMUSP00000109456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,644,374 - 4,671,726 (+)Ensembl
GRCm38.p6 Ensembl194,594,346 - 4,621,698 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223659
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,560,554 - 4,580,956 (+)Ensembl
GRCm38.p6 Ensembl194,510,526 - 4,530,928 (+)Ensembl
RefSeq Acc Id: ENSMUST00000224726   ⟹   ENSMUSP00000153479
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,560,514 - 4,671,707 (+)Ensembl
GRCm38.p6 Ensembl194,510,486 - 4,621,679 (+)Ensembl
RefSeq Acc Id: ENSMUST00000225189   ⟹   ENSMUSP00000152918
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,565,682 - 4,652,266 (+)Ensembl
GRCm38.p6 Ensembl194,515,654 - 4,602,238 (+)Ensembl
RefSeq Acc Id: ENSMUST00000236457   ⟹   ENSMUSP00000157492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,608,838 - 4,652,049 (+)Ensembl
GRCm38.p6 Ensembl194,558,810 - 4,602,021 (+)Ensembl
RefSeq Acc Id: ENSMUST00000238089   ⟹   ENSMUSP00000157436
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl194,644,436 - 4,652,277 (+)Ensembl
GRCm38.p6 Ensembl194,594,408 - 4,602,249 (+)Ensembl
RefSeq Acc Id: NM_001162946   ⟹   NP_001156418
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,560,500 - 4,671,780 (+)NCBI
GRCm38194,510,472 - 4,621,752 (+)ENTREZGENE
MGSCv37194,510,472 - 4,621,752 (+)RGD
Celera194,381,239 - 4,492,934 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008797   ⟹   NP_032823
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,644,347 - 4,671,780 (+)NCBI
GRCm38194,594,319 - 4,621,752 (+)NCBI
MGSCv37194,510,472 - 4,621,752 (+)RGD
Celera194,381,239 - 4,492,934 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006531678   ⟹   XP_006531741
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39194,644,331 - 4,671,731 (+)NCBI
GRCm38194,594,302 - 4,621,703 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032823   ⟸   NM_008797
- Peptide Label: isoform 2
- UniProtKB: Q05920 (UniProtKB/Swiss-Prot),   G5E8R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001156418   ⟸   NM_001162946
- Peptide Label: isoform 1
- UniProtKB: E9QPD7 (UniProtKB/TrEMBL),   Q3T9S7 (UniProtKB/TrEMBL),   Q3TCQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006531741   ⟸   XM_006531678
- Peptide Label: isoform X1
- UniProtKB: Q05920 (UniProtKB/Swiss-Prot),   G5E8R3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000157492   ⟸   ENSMUST00000236457
RefSeq Acc Id: ENSMUSP00000109456   ⟸   ENSMUST00000113825
RefSeq Acc Id: ENSMUSP00000152918   ⟸   ENSMUST00000225189
RefSeq Acc Id: ENSMUSP00000063825   ⟸   ENSMUST00000068004
RefSeq Acc Id: ENSMUSP00000157436   ⟸   ENSMUST00000238089
RefSeq Acc Id: ENSMUSP00000153479   ⟸   ENSMUST00000224726
Protein Domains
ATP-grasp   Biotin carboxylation   Biotinyl-binding   Lipoyl-binding   Pyruvate carboxyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q05920-F1-model_v2 AlphaFold Q05920 1-1178 view protein structure

Promoters
RGD ID:13678436
Promoter ID:EPDNEW_M23367
Type:initiation region
Name:Pcx_1
Description:Mus musculus pyruvate carboxylase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23368  EPDNEW_M23369  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,510,545 - 4,510,605EPDNEW
RGD ID:13678438
Promoter ID:EPDNEW_M23368
Type:multiple initiation site
Name:Pcx_3
Description:Mus musculus pyruvate carboxylase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23367  EPDNEW_M23369  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,514,524 - 4,514,584EPDNEW
RGD ID:6830285
Promoter ID:MM_KWN:26018
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Kidney,   Liver
Transcripts:NM_008797
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36194,593,986 - 4,594,486 (+)MPROMDB
RGD ID:13678442
Promoter ID:EPDNEW_M23369
Type:initiation region
Name:Pcx_2
Description:Mus musculus pyruvate carboxylase , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M23367  EPDNEW_M23368  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38194,594,385 - 4,594,445EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97520 AgrOrtholog
Ensembl Genes ENSMUSG00000024892 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068004 ENTREZGENE
  ENSMUST00000068004.13 UniProtKB/TrEMBL
  ENSMUST00000113825 ENTREZGENE
  ENSMUST00000113825.4 UniProtKB/TrEMBL
  ENSMUST00000224726 ENTREZGENE
  ENSMUST00000224726.3 UniProtKB/TrEMBL
  ENSMUST00000225189.3 UniProtKB/TrEMBL
  ENSMUST00000236457.2 UniProtKB/TrEMBL
  ENSMUST00000238089.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  pyruvate carboxylase f1077a mutant domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BC-like_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carboxylation_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_COase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carboxylase_cons_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CbamoylP_synth_lsu-like_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyruv_COase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rudment_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single_hybrid_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18563 UniProtKB/TrEMBL
MGD MGI:97520 ENTREZGENE
NCBI Gene 18563 ENTREZGENE
PANTHER PYRUVATE CARBOXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRUVATE CARBOXYLASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_carb_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Biotin_lipoyl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPSase_L_D2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGL-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYC_OADA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcx PhenoGen
PIRSF Pyruv_carbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ATP_GRASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BIOTINYL_LIPOYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50979 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYR_CT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Biotin_carb_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  post-HMGL domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A286YCC5_MOUSE UniProtKB/TrEMBL
  A0A494B912_MOUSE UniProtKB/TrEMBL
  A0A494B951_MOUSE UniProtKB/TrEMBL
  E9QPD7 ENTREZGENE, UniProtKB/TrEMBL
  G5E8R3 ENTREZGENE, UniProtKB/TrEMBL
  PYC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T9S7 ENTREZGENE, UniProtKB/TrEMBL
  Q3TCQ3 ENTREZGENE, UniProtKB/TrEMBL
  Q3UFS6_MOUSE UniProtKB/TrEMBL
  Q62043_MOUSE UniProtKB/TrEMBL
  Q8BP54_MOUSE UniProtKB/TrEMBL