Ago2 (argonaute RISC catalytic subunit 2) - Rat Genome Database

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Gene: Ago2 (argonaute RISC catalytic subunit 2) Mus musculus
Analyze
Symbol: Ago2
Name: argonaute RISC catalytic subunit 2
RGD ID: 732768
MGI Page MGI
Description: Enables RNA endonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in positive regulation of mRNA catabolic process and pre-miRNA processing. Acts upstream of or within ncRNA metabolic process; positive regulation of gene expression; and post-embryonic development. Located in several cellular components, including P-body; cytosol; and dendrite. Part of RISC complex and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and tooth. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Orthologous to human AGO2 (argonaute RISC catalytic component 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110029L17Rik; 2310051F07Rik; AI225898; AL022874; argonaute 2; argonaute RISC catalytic component 2; argonaute2; AW546247; eIF-2C 2; Eif2c; eIF2C 2; Eif2c2; ENSMUSG00000072493; eukaryotic translation initiation factor 2C, 2; Gerp95; Gm10365; KIAA4215; mAgo2; mKIAA4215; Piwi/Argonaute family protein meIF2C2; predicted gene 10365; protein argonaute-2; protein slicer; RIKEN cDNA 1110029L17 gene; RIKEN cDNA 2310051F07 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm11511   Gm12904   Gm5281   Gm6088  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391572,967,693 - 73,056,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1572,967,693 - 73,056,784 (-)EnsemblGRCm39 Ensembl
GRCm381573,101,625 - 73,184,947 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,095,844 - 73,184,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371572,932,055 - 73,015,377 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361572,934,117 - 73,012,065 (-)NCBIMGSCv36mm8
Celera1574,601,857 - 74,646,651 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1533.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (EXP)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (EXP)
acrolein  (ISO)
alachlor  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butyric acid  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cerium trichloride  (EXP)
CGP 52608  (ISO)
chloroprene  (ISO)
chrysene  (EXP)
cisplatin  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
excitatory amino acid agonist  (ISO)
fenthion  (EXP)
fipronil  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (ISO)
glucaric acid  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (ISO)
nicotinamide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP)
troglitazone  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)
vinclozolin  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cellular response to calcium ion  (ISO)
miRNA metabolic process  (IDA)
miRNA processing  (IMP,ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (IDA,ISO)
negative regulation of amyloid precursor protein biosynthetic process  (ISO)
negative regulation of translational initiation  (ISO)
P-body assembly  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  (IMP)
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  (IMP)
positive regulation of post-transcriptional gene silencing by RNA  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of translation  (ISO)
positive regulation of trophoblast cell migration  (ISO)
post-embryonic development  (IMP)
pre-miRNA processing  (IBA,IDA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of mRNA stability  (ISO)
regulation of synapse maturation  (ISO)
regulation of translation  (IEA)
regulatory ncRNA-mediated gene silencing  (IMP)
regulatory ncRNA-mediated post-transcriptional gene silencing  (IBA)
response to cocaine  (ISO)
response to hypoxia  (ISO)
response to morphine  (ISO)
RISC complex assembly  (ISO)
RNA secondary structure unwinding  (ISO)
siRNA processing  (ISO)
siRNA-mediated gene silencing by mRNA destabilization  (ISO)
spermatogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal embryonic tissue morphology  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythrocyte physiology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal forebrain development  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair follicle morphology  (IAGP)
abnormal pancreatic beta cell morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal proerythroblast morphology  (IAGP)
abnormal skin physiology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
anemia  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating insulin level  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased hematocrit  (IAGP)
decreased hemoglobin content  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased pancreatic beta cell mass  (IAGP)
decreased pancreatic beta cell number  (IAGP)
decreased pancreatic beta cell proliferation  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged spleen  (IAGP)
epidermal cyst  (IAGP)
hair follicle degeneration  (IAGP)
improved glucose tolerance  (IAGP)
increased circulating insulin level  (IAGP)
increased number of Heinz bodies  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell number  (IAGP)
increased red blood cell distribution width  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
open neural tube  (IAGP)
pallor  (IAGP)
pericardial edema  (IAGP)
placental labyrinth hypoplasia  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
reticulocytosis  (IAGP)
small placenta  (IAGP)
sparse hair  (IAGP)
thick epidermis  (IAGP)
wavy neural tube  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. García-Pérez D, etal., Addict Biol. 2015 Jan;20(1):104-19. doi: 10.1111/adb.12083. Epub 2013 Aug 8.
3. Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
4. Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Neuroprotection in Rodent Models of Glaucoma. Mead B, etal., Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):702-714. doi: 10.1167/iovs.17-22855.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12414724   PMID:12477932   PMID:12520002   PMID:12526743   PMID:12904583  
PMID:15284456   PMID:15489334   PMID:15741177   PMID:15747579   PMID:16033648   PMID:16036130   PMID:16141072   PMID:16141073   PMID:16357216   PMID:16751776   PMID:16778019   PMID:16800626  
PMID:17418524   PMID:17626790   PMID:17967808   PMID:18166081   PMID:18669659   PMID:18701707   PMID:18799693   PMID:19223321   PMID:19349980   PMID:19536157   PMID:19716330   PMID:19767612  
PMID:19808937   PMID:19838187   PMID:19898466   PMID:20014101   PMID:20102707   PMID:20109527   PMID:20185826   PMID:20353723   PMID:20386665   PMID:20424607   PMID:20513743   PMID:20643829  
PMID:20699384   PMID:20975942   PMID:21258322   PMID:21297615   PMID:21731673   PMID:21857111   PMID:21873635   PMID:21941127   PMID:22022532   PMID:22053081   PMID:22270084   PMID:22422842  
PMID:22474261   PMID:22484317   PMID:22503104   PMID:22505576   PMID:22508726   PMID:22735451   PMID:22844086   PMID:23178124   PMID:23185045   PMID:23248281   PMID:23340509   PMID:23358505  
PMID:23382546   PMID:23485552   PMID:23708604   PMID:24049110   PMID:24101522   PMID:24361012   PMID:24427314   PMID:24983771   PMID:24992693   PMID:25378171   PMID:25533351   PMID:25568082  
PMID:25695507   PMID:25697406   PMID:25722370   PMID:25724380   PMID:26009488   PMID:26140592   PMID:26265008   PMID:26304123   PMID:26332312   PMID:26809675   PMID:26850657   PMID:26850790  
PMID:27154007   PMID:27582469   PMID:27783951   PMID:28671696   PMID:28978771   PMID:29021386   PMID:29031931   PMID:29307557   PMID:29311329   PMID:29351846   PMID:29396181   PMID:29728425  
PMID:30201950   PMID:30344048   PMID:30348590   PMID:30651325   PMID:31040226   PMID:31138677   PMID:31289130   PMID:31324449   PMID:31330130   PMID:31657143   PMID:31740951   PMID:32296071  
PMID:32325033   PMID:32497496   PMID:32499547   PMID:32560809   PMID:32581705   PMID:32877400   PMID:33046105   PMID:33378226   PMID:33567453   PMID:33599613   PMID:33972443   PMID:34529004  
PMID:34907157   PMID:35301367   PMID:35533808   PMID:36293380   PMID:36769259   PMID:37094168   PMID:37178056   PMID:37280197   PMID:37330182   PMID:37402366   PMID:37810197   PMID:37963060  
PMID:37985687  


Genomics

Comparative Map Data
Ago2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391572,967,693 - 73,056,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1572,967,693 - 73,056,784 (-)EnsemblGRCm39 Ensembl
GRCm381573,101,625 - 73,184,947 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1573,095,844 - 73,184,935 (-)EnsemblGRCm38mm10GRCm38
MGSCv371572,932,055 - 73,015,377 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361572,934,117 - 73,012,065 (-)NCBIMGSCv36mm8
Celera1574,601,857 - 74,646,651 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1533.92NCBI
AGO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388140,520,156 - 140,642,313 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8140,520,156 - 140,635,633 (-)EnsemblGRCh38hg38GRCh38
GRCh378141,530,255 - 141,645,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,610,446 - 141,714,827 (-)NCBINCBI36Build 36hg18NCBI36
Build 348141,610,446 - 141,714,827NCBI
Celera8137,710,380 - 137,814,765 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8136,853,198 - 136,907,219 (-)NCBIHuRef
CHM1_18141,581,910 - 141,685,882 (-)NCBICHM1_1
T2T-CHM13v2.08141,640,512 - 141,762,332 (-)NCBIT2T-CHM13v2.0
Ago2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87106,907,209 - 106,994,124 (-)NCBIGRCr8
mRatBN7.27105,018,202 - 105,105,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7105,029,120 - 105,104,974 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07114,339,607 - 114,377,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7114,339,434 - 114,380,613 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07114,274,582 - 114,312,135 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47110,827,857 - 110,865,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17110,862,086 - 110,899,819 (-)NCBI
Celera7101,439,261 - 101,476,737 (-)NCBICelera
Cytogenetic Map7q34NCBI
Ago2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546114,205,748 - 14,253,861 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546114,194,268 - 14,260,949 (-)NCBIChiLan1.0ChiLan1.0
AGO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27157,913,911 - 158,030,054 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18133,444,339 - 133,560,536 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08137,192,037 - 137,308,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18140,278,610 - 140,361,124 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8140,287,647 - 140,361,125 (-)Ensemblpanpan1.1panPan2
AGO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11335,169,243 - 35,230,252 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1335,180,912 - 35,268,577 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1335,028,442 - 35,140,440 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01335,564,998 - 35,666,115 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1335,565,198 - 35,666,187 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11335,274,354 - 35,386,196 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01335,364,327 - 35,476,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01335,795,131 - 35,895,912 (-)NCBIUU_Cfam_GSD_1.0
Ago2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053033,202,184 - 3,264,488 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647010,628,128 - 10,680,106 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647010,641,109 - 10,690,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl42,919,511 - 3,015,334 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.142,966,794 - 3,012,388 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.242,362,700 - 2,405,419 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18134,761,651 - 134,855,971 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8134,767,182 - 134,823,070 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660395,263,683 - 5,390,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473515,785,114 - 15,842,435 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473515,785,831 - 15,853,854 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ago2
3017 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3405
Count of miRNA genes:896
Interacting mature miRNAs:1246
Transcripts:ENSMUST00000044113
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined348969478601286Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined348969478601286Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined348969478601286Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15348969478601286Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15348969478601286Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15612948175871849Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15612948176384200Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15612948178684200Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15692948175871849Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15692948175871849Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927302279474762Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930014676084200Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153910039573100593Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154455331378553437Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154485914178859281Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155100469476794493Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
25671381Hrsq3_mhost response to SARS QTL 3, eosinophilia (mouse)157214453975844833Mouse
1300844Emo2_memotionality 2 (mouse)Not determined157237245976794493Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse

Markers in Region
Eif2c2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373135,712,774 - 135,713,461UniSTSGRCm37
Celera3142,473,636 - 142,474,323UniSTS
Cytogenetic Map15D3UniSTS
cM Map15 UniSTS
cM Map1533.92UniSTS
RH135997  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,096,996 - 73,097,274UniSTSGRCm38
MGSCv371572,927,426 - 72,927,704UniSTSGRCm37
Celera1574,597,228 - 74,597,506UniSTS
Cytogenetic Map15D3UniSTS
AW546247  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,098,727 - 73,098,842UniSTSGRCm38
MGSCv371572,929,157 - 72,929,272UniSTSGRCm37
Celera1574,598,959 - 74,599,074UniSTS
Cytogenetic Map15D3UniSTS
Whitehead/MRC_RH15609.79UniSTS
42.MMHAP37FRF12.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,149,117 - 73,149,278UniSTSGRCm38
GRCm381573,149,117 - 73,150,621UniSTSGRCm38
MGSCv371572,979,547 - 72,979,708UniSTSGRCm37
MGSCv371572,979,547 - 72,981,051UniSTSGRCm37
Celera1574,649,184 - 74,649,345UniSTS
Celera1574,649,184 - 74,650,688UniSTS
Cytogenetic Map15D3UniSTS
Whitehead/MRC_RH15611.11UniSTS
D15Mit197  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,117,593 - 73,117,703UniSTSGRCm38
MGSCv371572,948,023 - 72,948,133UniSTSGRCm37
Celera1574,617,676 - 74,617,786UniSTS
Cytogenetic Map15D3UniSTS
cM Map1541.9UniSTS
Whitehead Genetic1532.8UniSTS
Whitehead_YAC15 UniSTS
RH125371  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,098,582 - 73,098,766UniSTSGRCm38
MGSCv371572,929,012 - 72,929,196UniSTSGRCm37
Celera1574,598,814 - 74,598,998UniSTS
Cytogenetic Map15D3UniSTS
UniSTS:237320  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,097,402 - 73,097,494UniSTSGRCm38
MGSCv371572,927,832 - 72,927,924UniSTSGRCm37
Celera1574,597,634 - 74,597,726UniSTS
Cytogenetic Map15D3UniSTS
BG378661  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381573,182,277 - 73,182,432UniSTSGRCm38
MGSCv371573,012,707 - 73,012,862UniSTSGRCm37
Celera1574,682,349 - 74,682,504UniSTS
Cytogenetic Map15D3UniSTS
Eif2c2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,049,810 - 136,050,497UniSTSGRCm38
MGSCv373135,712,774 - 135,713,461UniSTSGRCm37
Celera3142,473,636 - 142,474,323UniSTS
Cytogenetic Map3G3UniSTS
Cytogenetic Map15D3UniSTS
Eif2c2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15D3UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_153178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA058301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AA764090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB081472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC118640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI225898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI225899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI415636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK003962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK148725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL118169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW546247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY135688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB765875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC056639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC128379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE650477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG072618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP767325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY731067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY732637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA752432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ056675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ540998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ543695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ543696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ546154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ549215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ692047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ693350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ713527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000044113   ⟹   ENSMUSP00000042207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1572,967,693 - 73,056,784 (-)Ensembl
GRCm38.p6 Ensembl1573,095,844 - 73,184,935 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230158
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1572,979,182 - 72,985,903 (-)Ensembl
GRCm38.p6 Ensembl1573,107,333 - 73,114,054 (-)Ensembl
RefSeq Acc Id: ENSMUST00000230464
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1573,000,271 - 73,049,696 (-)Ensembl
GRCm38.p6 Ensembl1573,128,422 - 73,177,847 (-)Ensembl
RefSeq Acc Id: NM_153178   ⟹   NP_694818
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391572,967,693 - 73,056,777 (-)NCBI
GRCm381573,101,625 - 73,184,947 (-)ENTREZGENE
MGSCv371572,932,055 - 73,015,377 (-)RGD
Celera1574,601,857 - 74,646,651 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_694818   ⟸   NM_153178
- UniProtKB: Q4VAB3 (UniProtKB/Swiss-Prot),   A1A563 (UniProtKB/Swiss-Prot),   Q571J6 (UniProtKB/Swiss-Prot),   Q8CJG0 (UniProtKB/Swiss-Prot),   Q8CGT9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000042207   ⟸   ENSMUST00000044113
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJG0-F1-model_v2 AlphaFold Q8CJG0 1-860 view protein structure

Promoters
RGD ID:6825957
Promoter ID:MM_KWN:18697
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:AK142854_GM10365,   UC007WBT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361572,932,341 - 72,936,067 (-)MPROMDB
RGD ID:6825951
Promoter ID:MM_KWN:18698
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Lung
Transcripts:NM_153178
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361573,014,996 - 73,016,097 (-)MPROMDB
RGD ID:8683920
Promoter ID:EPDNEW_M19988
Type:initiation region
Name:Ago2_1
Description:Mus musculus argonaute RISC catalytic subunit 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381573,184,901 - 73,184,961EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446632 AgrOrtholog
Ensembl Genes ENSMUSG00000036698 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000044113 ENTREZGENE
  ENSMUST00000044113.12 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  paz domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AGO2 UniProtKB/Swiss-Prot
  ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:239528 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2446632 ENTREZGENE
NCBI Gene 239528 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoMid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ago2 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DUF1785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1A563 ENTREZGENE
  AGO2_MOUSE UniProtKB/Swiss-Prot
  Q3UQ34_MOUSE UniProtKB/TrEMBL
  Q4VAB3 ENTREZGENE
  Q571J6 ENTREZGENE
  Q6P239_MOUSE UniProtKB/TrEMBL
  Q6PHA2_MOUSE UniProtKB/TrEMBL
  Q8CGT9 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJG0 ENTREZGENE
  Q8R3Q7_MOUSE UniProtKB/TrEMBL
UniProt Secondary A1A563 UniProtKB/Swiss-Prot
  Q4VAB3 UniProtKB/Swiss-Prot
  Q571J6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-31 Ago2  argonaute RISC catalytic subunit 2  Gm10365  predicted gene 10365  Data merged from RGD:1624713 737654 PROVISIONAL
2016-03-22 Ago2  argonaute RISC catalytic subunit 2  2310051F07Rik  RIKEN cDNA 2310051F07 gene  Data merged from RGD:1609493 737654 PROVISIONAL
2016-02-25 Ago2  argonaute RISC catalytic subunit 2  1110029L17Rik  RIKEN cDNA 1110029L17 gene  Data merged from RGD:1608142 737654 PROVISIONAL
2013-02-27 Ago2  argonaute RISC catalytic subunit 2  Eif2c2  eukaryotic translation initiation factor 2C, 2  Symbol and/or name change 5135510 APPROVED