Pex14 (peroxisomal biogenesis factor 14) - Rat Genome Database

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Gene: Pex14 (peroxisomal biogenesis factor 14) Mus musculus
Analyze
Symbol: Pex14
Name: peroxisomal biogenesis factor 14
RGD ID: 68471
MGI Page MGI
Description: Predicted to enable several functions, including identical protein binding activity; transcription corepressor activity; and tubulin binding activity. Predicted to be involved in several processes, including cellular response to reactive oxygen species; peroxisome transport along microtubule; and protein import into peroxisome matrix. Predicted to act upstream of or within protein transport. Located in peroxisomal membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 13A. Orthologous to human PEX14 (peroxisomal biogenesis factor 14).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: peroxin-14; peroxisomal membrane anchor protein PEX14; peroxisomal membrane protein PEX14; peroxisomal protein Pex14; Pex1; Pex14p; PTS1 receptor-docking protein; R75137
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,044,992 - 149,184,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,044,992 - 149,184,333 (-)EnsemblGRCm39 Ensembl
GRCm384148,960,535 - 149,099,843 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,960,535 - 149,099,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv374148,334,644 - 148,473,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,804,335 - 147,943,612 (-)NCBIMGSCv36mm8
Celera4151,224,014 - 151,367,395 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:11042159   PMID:11060021   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12488033   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14634209  
PMID:14681479   PMID:15026142   PMID:15489334   PMID:15741177   PMID:15782199   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16449325   PMID:17881773   PMID:17967808   PMID:18799693  
PMID:21873635   PMID:21954064   PMID:32266253   PMID:32325033   PMID:32831175   PMID:35315772   PMID:37311584  


Genomics

Comparative Map Data
Pex14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394149,044,992 - 149,184,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4149,044,992 - 149,184,333 (-)EnsemblGRCm39 Ensembl
GRCm384148,960,535 - 149,099,843 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4148,960,535 - 149,099,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv374148,334,644 - 148,473,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364147,804,335 - 147,943,612 (-)NCBIMGSCv36mm8
Celera4151,224,014 - 151,367,395 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map478.87NCBI
PEX14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38110,474,950 - 10,630,758 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl110,472,288 - 10,630,758 (+)EnsemblGRCh38hg38GRCh38
GRCh37110,535,007 - 10,690,815 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36110,457,590 - 10,613,402 (+)NCBINCBI36Build 36hg18NCBI36
Build 34110,469,284 - 10,625,079NCBI
Celera19,646,407 - 9,802,209 (+)NCBICelera
Cytogenetic Map1p36.22NCBI
HuRef19,688,564 - 9,844,851 (+)NCBIHuRef
CHM1_1110,522,760 - 10,678,540 (+)NCBICHM1_1
T2T-CHM13v2.0110,018,554 - 10,174,355 (+)NCBIT2T-CHM13v2.0
Pex14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85164,682,876 - 164,819,352 (-)NCBIGRCr8
mRatBN7.25159,399,776 - 159,536,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5159,399,776 - 159,536,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5162,116,476 - 162,252,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05163,938,080 - 164,073,727 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05163,894,450 - 164,030,099 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05165,782,895 - 165,918,445 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5165,782,895 - 165,918,445 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05169,433,225 - 169,568,626 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45166,038,317 - 166,174,652 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15166,048,504 - 166,184,840 (-)NCBI
Celera5157,671,940 - 157,807,205 (-)NCBICelera
Cytogenetic Map5q36NCBI
Pex14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554862,980,700 - 3,129,721 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554862,981,026 - 3,129,721 (-)NCBIChiLan1.0ChiLan1.0
PEX14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21217,596,325 - 217,752,497 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11216,242,429 - 216,398,429 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v019,234,928 - 9,391,086 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1110,459,863 - 10,614,187 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl110,459,884 - 10,614,187 (+)Ensemblpanpan1.1panPan2
PEX14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1285,379,378 - 85,389,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,981,475 - 81,990,564 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,111,196 - 86,124,207 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,114,196 - 86,124,084 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,862,365 - 82,871,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0283,864,867 - 83,873,956 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,927,777 - 84,936,866 (-)NCBIUU_Cfam_GSD_1.0
LOC101959362
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505833,780,359 - 33,977,224 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366234,265,559 - 4,289,590 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049366234,313,147 - 4,462,528 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366234,313,186 - 4,462,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PEX14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl670,737,905 - 70,872,072 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1670,737,871 - 70,872,074 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2664,670,674 - 64,805,059 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PEX14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120121,152,514 - 121,309,888 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20121,152,498 - 121,309,919 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605425,065,864 - 25,223,768 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pex14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248182,082,709 - 2,224,899 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248182,082,709 - 2,224,235 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pex14
388 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:821
Count of miRNA genes:495
Interacting mature miRNAs:581
Transcripts:ENSMUST00000103217, ENSMUST00000128067, ENSMUST00000134747, ENSMUST00000148203, ENSMUST00000154860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4127784226156860686Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4127784226156860686Mouse
1301584Lrdg2_mlight induced retinal degeneration 2 (mouse)Not determined4129465811151654550Mouse
1300874Gasa2_mgastritis type A susceptibility locus 2 (mouse)Not determined4133010494156860686Mouse
1301267Bcmd2_mB cell maturation defect 2 (mouse)Not determined4133154678150789451Mouse
4142077Ignpq2_mIgA nephropathy QTL 2 (mouse)Not determined4133676733156860686Mouse
1301108Scon2_msucrose consumption 2 (mouse)Not determined4134654451156860686Mouse
1300537Ap3q_malcohol preference 3 QTL (mouse)Not determined4134654451156860686Mouse
1300553Athsq1_matherosclerosis susceptibility QTL 1 (mouse)Not determined4137617848151654550Mouse
4141184Tb2r1_mTGF-beta2 responsiveness 1 (mouse)Not determined137674005150676858Mouse
1300780Cocrb16_mcocaine related behavior 16 (mouse)Not determined4138943725156860686Mouse

Markers in Region
MDB1083  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,960,620 - 148,960,772UniSTSGRCm38
MGSCv374148,334,729 - 148,334,881UniSTSGRCm37
Celera4151,224,099 - 151,224,251UniSTS
Cytogenetic Map4E2UniSTS
Whitehead_YAC4 UniSTS
RH125171  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384148,960,619 - 148,960,723UniSTSGRCm38
MGSCv374148,334,728 - 148,334,832UniSTSGRCm37
Celera4151,224,098 - 151,224,202UniSTS
Cytogenetic Map4E2UniSTS
SGC38258  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384149,074,157 - 149,074,419UniSTSGRCm38
MGSCv374148,448,266 - 148,448,528UniSTSGRCm37
Celera4151,338,007 - 151,338,269UniSTS
Cytogenetic Map4E2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000103217   ⟹   ENSMUSP00000099506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,044,992 - 149,184,333 (-)Ensembl
GRCm38.p6 Ensembl4148,960,535 - 149,099,876 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128067
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,047,689 - 149,184,273 (-)Ensembl
GRCm38.p6 Ensembl4148,963,232 - 149,099,816 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134747   ⟹   ENSMUSP00000116791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,068,562 - 149,184,266 (-)Ensembl
GRCm38.p6 Ensembl4148,984,105 - 149,099,809 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148203
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,098,843 - 149,184,285 (-)Ensembl
GRCm38.p6 Ensembl4149,014,386 - 149,099,828 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4149,067,811 - 149,184,272 (-)Ensembl
GRCm38.p6 Ensembl4148,983,354 - 149,099,815 (-)Ensembl
RefSeq Acc Id: NM_019781   ⟹   NP_062755
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394149,044,992 - 149,184,300 (-)NCBI
GRCm384148,960,535 - 149,099,843 (-)NCBI
MGSCv374148,334,644 - 148,473,921 (-)RGD
Celera4151,224,014 - 151,367,395 (-)RGD
cM Map4 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062755   ⟸   NM_019781
- UniProtKB: Q9R0A0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000116791   ⟸   ENSMUST00000134747
RefSeq Acc Id: ENSMUSP00000099506   ⟸   ENSMUST00000103217
Protein Domains
Peroxisome membrane anchor protein Pex14p N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0A0-F1-model_v2 AlphaFold Q9R0A0 1-376 view protein structure

Promoters
RGD ID:6835835
Promoter ID:MM_KWN:40848
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000025663,   OTTMUST00000025664,   OTTMUST00000070378,   OTTMUST00000070379,   OTTMUST00000070380
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364148,473,511 - 148,474,011 (-)MPROMDB
RGD ID:6885544
Promoter ID:EPDNEW_M6223
Type:multiple initiation site
Name:Pex14_1
Description:Mus musculus peroxisomal biogenesis factor 14 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384149,099,824 - 149,099,884EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927868 AgrOrtholog
Ensembl Genes ENSMUSG00000028975 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000103217 ENTREZGENE
  ENSMUST00000103217.11 UniProtKB/Swiss-Prot
  ENSMUST00000134747.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PEX14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pex14_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56273 UniProtKB/Swiss-Prot
MGD MGI:1927868 ENTREZGENE
NCBI Gene 56273 ENTREZGENE
PANTHER PEROXISOMAL MEMBRANE PROTEIN PEX14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23058 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pex14_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pex14 PhenoGen
UniProt D6RH82_MOUSE UniProtKB/TrEMBL
  PEX14_MOUSE UniProtKB/Swiss-Prot
  Q9QX52_MOUSE UniProtKB/TrEMBL
  Q9R0A0 ENTREZGENE