Znf780b (zinc finger protein 780B) - Rat Genome Database

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Gene: Znf780b (zinc finger protein 780B) Rattus norvegicus
Analyze
Symbol: Znf780b (Ensembl: Zfp780b)
Name: zinc finger protein 780B
RGD ID: 6500398
Description: Predicted to enable metal ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human ZNF780A (zinc finger protein 780A) and ZNF780B (zinc finger protein 780B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; thioacetamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC100909824; LOC100910046; zinc finger protein 60; zinc finger protein 60-like
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,136,761 - 92,159,076 (+)NCBIGRCr8
mRatBN7.2183,009,174 - 83,030,463 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,009,189 - 83,082,107 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0184,576,059 - 84,656,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,584,596 - 84,598,186 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,806,198 - 85,828,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera177,413,364 - 77,540,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Znf780b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,136,761 - 92,159,076 (+)NCBIGRCr8
mRatBN7.2183,009,174 - 83,030,463 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,009,189 - 83,082,107 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0184,576,059 - 84,656,464 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,584,596 - 84,598,186 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,806,198 - 85,828,278 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera177,413,364 - 77,540,315 (+)NCBICelera
Cytogenetic Map1q21NCBI
ZNF780B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,028,260 - 40,056,231 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,028,260 - 40,056,231 (-)EnsemblGRCh38hg38GRCh38
GRCh371940,534,167 - 40,562,138 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,232,104 - 45,248,079 (-)NCBINCBI36Build 36hg18NCBI36
Celera1937,332,535 - 37,360,483 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,970,631 - 36,998,579 (-)NCBIHuRef
CHM1_11940,534,210 - 40,562,158 (-)NCBICHM1_1
T2T-CHM13v2.01942,848,466 - 42,876,439 (-)NCBIT2T-CHM13v2.0
Zfp780b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,658,560 - 27,678,768 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,658,560 - 27,678,596 (-)EnsemblGRCm39 Ensembl
GRCm38727,959,135 - 27,979,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,959,135 - 27,979,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv37728,744,819 - 28,764,176 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,667,752 - 27,687,930 (-)NCBIMGSCv36mm8
Celera722,535,097 - 22,554,454 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.97NCBI

Variants

.
Variants in Znf780b
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000032933
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 4 6 4 73 12 25 3
Low 3 43 47 37 13 37 8 10 1 23 16 8 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032933   ⟹   ENSRNOP00000037471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,059,010 - 83,082,107 (+)Ensembl
Rnor_6.0 Ensembl184,584,596 - 84,598,186 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073966   ⟹   ENSRNOP00000065360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,191 - 83,027,748 (+)Ensembl
Rnor_6.0 Ensembl184,530,669 - 84,543,966 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077133   ⟹   ENSRNOP00000071450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl184,530,669 - 84,531,855 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101873   ⟹   ENSRNOP00000086019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,189 - 83,082,107 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112009   ⟹   ENSRNOP00000097737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl183,009,189 - 83,027,748 (+)Ensembl
RefSeq Acc Id: XM_039100839   ⟹   XP_038956767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,136,761 - 92,159,076 (+)NCBI
mRatBN7.2183,009,174 - 83,030,463 (+)NCBI
RefSeq Acc Id: XM_039100840   ⟹   XP_038956768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,136,773 - 92,159,076 (+)NCBI
mRatBN7.2183,009,174 - 83,030,463 (+)NCBI
RefSeq Acc Id: XM_039100841   ⟹   XP_038956769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,141,971 - 92,159,076 (+)NCBI
mRatBN7.2183,014,383 - 83,030,463 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038956767 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956768 (Get FASTA)   NCBI Sequence Viewer  
  XP_038956769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065360
  ENSRNOP00000065360.3
  ENSRNOP00000086019.1
  ENSRNOP00000097737.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000037471   ⟸   ENSRNOT00000032933
RefSeq Acc Id: XP_038956768   ⟸   XM_039100840
- Peptide Label: isoform X1
- UniProtKB: M0R7D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956767   ⟸   XM_039100839
- Peptide Label: isoform X1
- UniProtKB: M0R7D4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956769   ⟸   XM_039100841
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000071450   ⟸   ENSRNOT00000077133
RefSeq Acc Id: ENSRNOP00000065360   ⟸   ENSRNOT00000073966
RefSeq Acc Id: ENSRNOP00000086019   ⟸   ENSRNOT00000101873
RefSeq Acc Id: ENSRNOP00000097737   ⟸   ENSRNOT00000112009
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R7D4-F1-model_v2 AlphaFold M0R7D4 1-610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6500398 AgrOrtholog
BioCyc Gene G2FUF-60295 BioCyc
Ensembl Genes ENSRNOG00000018885 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000046338 Ensembl
Ensembl Transcript ENSRNOT00000073966.3 UniProtKB/TrEMBL
  ENSRNOT00000101873.1 UniProtKB/TrEMBL
  ENSRNOT00000112009.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene LOC100910046 ENTREZGENE
PANTHER FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED UniProtKB/TrEMBL
  KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  KRAB DOMAIN-CONTAINING PROTEIN 5-RELATED UniProtKB/TrEMBL
  SI:DKEY-15H8.11 PROTEIN-RELATED UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 345-RELATED UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-C2H2_6 UniProtKB/TrEMBL
PhenoGen Znf780b PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018885 RatGTEx
  ENSRNOG00000046338 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A8I6ARQ8_RAT UniProtKB/TrEMBL
  A0A8I6GEI7_RAT UniProtKB/TrEMBL
  M0R7D4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-08 Znf780b  zinc finger protein 780B  LOC100910046  zinc finger protein 60-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 LOC100910046  zinc finger protein 60-like  LOC100909824  zinc finger protein 60-like  Data merged from RGD:6501656 737654 PROVISIONAL
2012-07-05 LOC100910046  zinc finger protein 60-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909824  zinc finger protein 60-like      Symbol and Name status set to provisional 70820 PROVISIONAL