PRM2 (protamine 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: PRM2 (protamine 2) Homo sapiens
Analyze
Symbol: PRM2
Name: protamine 2
RGD ID: 737276
HGNC Page HGNC:9448
Description: Enables cadmium ion binding activity and zinc ion binding activity. Involved in sequestering of metal ion. Located in nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cancer/testis antigen family 94, member 2; CT94.2; FLJ27447; protamine-2; sperm histone P2; sperm protamine P2; testicular secretory protein Li 40
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,275,639 - 11,276,480 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,275,639 - 11,276,480 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,369,496 - 11,370,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,276,994 - 11,277,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,276,997 - 11,277,809NCBI
Celera1611,538,883 - 11,539,727 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBIHuRef
CHM1_11611,369,399 - 11,370,243 (-)NCBICHM1_1
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
cytoplasm  (ISO)
male germ cell nucleus  (IEA)
nucleoplasm  (TAS)
nucleosome  (IEA)
nucleus  (HDA,IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1889406   PMID:1907596   PMID:2081589   PMID:2243113   PMID:2370044   PMID:2384091   PMID:3403514   PMID:3412906   PMID:3527226   PMID:3956509   PMID:7714151   PMID:7983046  
PMID:8024562   PMID:8513794   PMID:9239704   PMID:9282840   PMID:9795985   PMID:10659848   PMID:10898591   PMID:11326282   PMID:11686187   PMID:11869379   PMID:12477932   PMID:12524352  
PMID:12569175   PMID:15342556   PMID:15489334   PMID:15670415   PMID:16344560   PMID:16632464   PMID:16989827   PMID:17011555   PMID:17113348   PMID:18292840   PMID:18292846   PMID:18309899  
PMID:18314125   PMID:18478156   PMID:18692784   PMID:19602509   PMID:19863670   PMID:20378615   PMID:21029114   PMID:21317160   PMID:21630459   PMID:21873635   PMID:22104739   PMID:22190364  
PMID:22472940   PMID:23271023   PMID:23568457   PMID:24453475   PMID:25416956   PMID:25536093   PMID:25649960   PMID:26392304   PMID:28736810   PMID:28854581   PMID:29227750   PMID:30482464  
PMID:32296183   PMID:32748386   PMID:33057064   PMID:33427330   PMID:33440036   PMID:33961781   PMID:34235877   PMID:36217675  


Genomics

Comparative Map Data
PRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381611,275,639 - 11,276,480 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1611,275,639 - 11,276,480 (-)EnsemblGRCh38hg38GRCh38
GRCh371611,369,496 - 11,370,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361611,276,994 - 11,277,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 341611,276,997 - 11,277,809NCBI
Celera1611,538,883 - 11,539,727 (-)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBIHuRef
CHM1_11611,369,399 - 11,370,243 (-)NCBICHM1_1
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBIT2T-CHM13v2.0
Prm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,609,241 - 10,609,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,609,244 - 10,613,998 (-)EnsemblGRCm39 Ensembl
GRCm381610,791,377 - 10,792,105 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,791,380 - 10,796,134 (-)EnsemblGRCm38mm10GRCm38
MGSCv371610,791,474 - 10,792,190 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,704,959 - 10,705,675 (-)NCBIMGSCv36mm8
Celera1611,418,811 - 11,419,527 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.84NCBI
Prm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,383,208 - 5,383,949 (+)NCBIGRCr8
mRatBN7.2104,876,285 - 4,877,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl104,873,372 - 4,877,026 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,572,973 - 9,573,409 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,094,089 - 9,094,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,732,370 - 4,732,806 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0104,950,484 - 4,950,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,950,484 - 4,950,920 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,776,970 - 3,777,406 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,813,692 - 4,814,128 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1104,813,691 - 4,814,128 (+)NCBI
Celera103,897,994 - 3,898,430 (+)NCBICelera
Cytogenetic Map10q11NCBI
PRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,824,801 - 11,825,700 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,595,263 - 15,596,125 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01610,217,586 - 10,218,446 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,439,417 - 11,440,265 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,439,417 - 11,440,265 (-)Ensemblpanpan1.1panPan2
PRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,492,208 - 31,492,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,492,208 - 31,492,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha632,875,074 - 32,875,718 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,674,848 - 31,675,492 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl631,674,848 - 31,675,492 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1631,488,145 - 31,488,789 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,362,449 - 31,363,093 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0631,786,678 - 31,787,322 (+)NCBIUU_Cfam_GSD_1.0
PRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl331,864,350 - 31,864,961 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1331,864,350 - 31,864,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2332,653,946 - 32,654,670 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,752,537 - 10,753,414 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,752,804 - 10,753,273 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,410,480 - 19,411,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,459,655 - 8,462,971 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRM2
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.3-13.13(chr16:23141-11296695)x3 copy number gain See cases [RCV000052367] Chr16:23141..11296695 [GRCh38]
Chr16:73141..11390552 [GRCh37]
Chr16:13141..11298053 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh38/hg38 16p13.3-13.13(chr16:46766-11525516)x3 copy number gain See cases [RCV000133780] Chr16:46766..11525516 [GRCh38]
Chr16:96766..11619372 [GRCh37]
Chr16:36766..11526873 [NCBI36]
Chr16:16p13.3-13.13		 pathogenic
GRCh38/hg38 16p13.13(chr16:10778551-11374173)x3 copy number gain See cases [RCV000137607] Chr16:10778551..11374173 [GRCh38]
Chr16:10872408..11468030 [GRCh37]
Chr16:10779909..11375531 [NCBI36]
Chr16:16p13.13		 likely benign
GRCh38/hg38 16p13.3-13.12(chr16:43732-13326806)x3 copy number gain See cases [RCV000139166] Chr16:43732..13326806 [GRCh38]
Chr16:93732..13420663 [GRCh37]
Chr16:33732..13328164 [NCBI36]
Chr16:16p13.3-13.12		 pathogenic
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11		 pathogenic
GRCh37/hg19 16p13.13(chr16:11173868-11681288)x3 copy number gain See cases [RCV000240209] Chr16:11173868..11681288 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Breast ductal adenocarcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3		 uncertain significance
GRCh37/hg19 16p13.2-13.13(chr16:9631472-12128275)x3 copy number gain See cases [RCV000511571] Chr16:9631472..12128275 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NM_002762.4(PRM2):c.254G>A (p.Arg85Gln) single nucleotide variant not specified [RCV004299452] Chr16:11276117 [GRCh38]
Chr16:11369974 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_002762.4(PRM2):c.121G>A (p.Val41Ile) single nucleotide variant not specified [RCV004306780] Chr16:11276250 [GRCh38]
Chr16:11370107 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.13(chr16:10529891-11889585)x3 copy number gain not provided [RCV000683759] Chr16:10529891..11889585 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.271+10C>T single nucleotide variant not provided [RCV000957374] Chr16:11276090 [GRCh38]
Chr16:11369947 [GRCh37]
Chr16:16p13.13		 benign
NC_000016.10:g.11276759G>A single nucleotide variant not provided [RCV001671042] Chr16:11276759 [GRCh38]
Chr16:11370616 [GRCh37]
Chr16:16p13.13		 benign
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.13(chr16:11124777-11387164)x1 copy number loss not provided [RCV000846621] Chr16:11124777..11387164 [GRCh37]
Chr16:16p13.13		 uncertain significance
NC_000016.9:g.(?_8829597)_(11683693_?)dup duplication Landau-Kleffner syndrome [RCV003105356] Chr16:8829597..11683693 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NC_000016.10:g.11275571C>T single nucleotide variant not provided [RCV001669744] Chr16:11275571 [GRCh38]
Chr16:11369428 [GRCh37]
Chr16:16p13.13		 benign
NC_000016.10:g.11276741C>G single nucleotide variant not provided [RCV001650193] Chr16:11276741 [GRCh38]
Chr16:11370598 [GRCh37]
Chr16:16p13.13		 benign
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
NC_000016.10:g.11276596C>T single nucleotide variant not provided [RCV001724499] Chr16:11276596 [GRCh38]
Chr16:11370453 [GRCh37]
Chr16:16p13.13		 benign
NC_000016.9:g.(?_8829597)_(11650586_?)dup duplication Charcot-Marie-Tooth disease type 1C [RCV003120793]|MHC class II deficiency [RCV002000309] Chr16:8829597..11650586 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NM_002762.4(PRM2):c.31G>A (p.Glu11Lys) single nucleotide variant not specified [RCV004140371] Chr16:11276340 [GRCh38]
Chr16:11370197 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.14G>A (p.Arg5His) single nucleotide variant not specified [RCV004270827] Chr16:11276357 [GRCh38]
Chr16:11370214 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.185G>C (p.Arg62Thr) single nucleotide variant not specified [RCV004515286] Chr16:11276186 [GRCh38]
Chr16:11370043 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.271+27G>C single nucleotide variant not provided [RCV001686405] Chr16:11276073 [GRCh38]
Chr16:11369930 [GRCh37]
Chr16:16p13.13		 benign
NM_002762.4(PRM2):c.272-61C>A single nucleotide variant not provided [RCV001716436] Chr16:11275998 [GRCh38]
Chr16:11369855 [GRCh37]
Chr16:16p13.13		 benign
NM_002762.4(PRM2):c.229C>T (p.Arg77Cys) single nucleotide variant not specified [RCV004313912] Chr16:11276142 [GRCh38]
Chr16:11369999 [GRCh37]
Chr16:16p13.13		 uncertain significance
GRCh37/hg19 16p13.13-13.12(chr16:11364838-13592668) copy number gain not specified [RCV002052521] Chr16:11364838..13592668 [GRCh37]
Chr16:16p13.13-13.12		 uncertain significance
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.2-13.13(chr16:10423631-12176517)x3 copy number gain not provided [RCV002474875] Chr16:10423631..12176517 [GRCh37]
Chr16:16p13.2-13.13		 uncertain significance
NM_002762.4(PRM2):c.8G>A (p.Arg3Gln) single nucleotide variant not specified [RCV004217213] Chr16:11276363 [GRCh38]
Chr16:11370220 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.94G>A (p.Glu32Lys) single nucleotide variant not specified [RCV004080954] Chr16:11276277 [GRCh38]
Chr16:11370134 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.293C>G (p.Thr98Arg) single nucleotide variant not specified [RCV004083027] Chr16:11275916 [GRCh38]
Chr16:11369773 [GRCh37]
Chr16:16p13.13		 likely benign
NM_002762.4(PRM2):c.257G>A (p.Arg86Lys) single nucleotide variant not specified [RCV004266960] Chr16:11276114 [GRCh38]
Chr16:11369971 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.60G>T (p.Gln20His) single nucleotide variant not specified [RCV004350548] Chr16:11276311 [GRCh38]
Chr16:11370168 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.*4T>A single nucleotide variant not provided [RCV003426588] Chr16:11275896 [GRCh38]
Chr16:11369753 [GRCh37]
Chr16:16p13.13		 likely benign
NM_002762.4(PRM2):c.13C>T (p.Arg5Cys) single nucleotide variant not specified [RCV004515284] Chr16:11276358 [GRCh38]
Chr16:11370215 [GRCh37]
Chr16:16p13.13		 uncertain significance
NM_002762.4(PRM2):c.161G>A (p.Arg54Lys) single nucleotide variant not specified [RCV004515285] Chr16:11276210 [GRCh38]
Chr16:11370067 [GRCh37]
Chr16:16p13.13		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:226
Interacting mature miRNAs:235
Transcripts:ENST00000241808, ENST00000435245
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-12339  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371611,369,497 - 11,369,720UniSTSGRCh37
Build 361611,276,998 - 11,277,221RGDNCBI36
Celera1611,538,887 - 11,539,110RGD
Cytogenetic Map16p13.2UniSTS
HuRef1611,287,228 - 11,287,451UniSTS
TNG Radiation Hybrid Map165628.0UniSTS
GeneMap99-G3 RH Map16479.0UniSTS
PMC151395P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371611,369,738 - 11,370,117UniSTSGRCh37
Build 361611,277,239 - 11,277,618RGDNCBI36
Celera1611,539,128 - 11,539,507RGD
Cytogenetic Map16p13.2UniSTS
HuRef1611,287,469 - 11,287,848UniSTS
GDB:438999  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371611,370,608 - 11,371,102UniSTSGRCh37
Celera1611,539,998 - 11,540,486UniSTS
Cytogenetic Map16p13.2UniSTS
HuRef1611,288,339 - 11,288,827UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage pharyngeal arch
High 1 1 2 2 356 1 2
Medium 37 35 41 7 6 6 82 24 39 2 47 32 1 33 46
Low 1238 1087 861 265 504 154 1464 881 1230 58 479 648 110 474 971 1
Below cutoff 452 596 272 97 283 68 840 482 911 45 153 235 29 229 564

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001286356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001286359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB281137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC009121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF215713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK131573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP368978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP371180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB066857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB066922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU190363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM005580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OQ884716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OQ927987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  OQ948475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X07862 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z46940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000241808   ⟹   ENSP00000241808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1611,275,639 - 11,276,480 (-)Ensembl
RefSeq Acc Id: ENST00000435245   ⟹   ENSP00000403681
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1611,275,640 - 11,276,480 (-)Ensembl
RefSeq Acc Id: NM_001286356   ⟹   NP_001273285
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBI
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286357   ⟹   NP_001273286
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBI
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286358   ⟹   NP_001273287
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBI
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001286359   ⟹   NP_001273288
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBI
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002762   ⟹   NP_002753
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
GRCh371611,369,493 - 11,370,337 (-)ENTREZGENE
GRCh371611,369,493 - 11,370,337 (-)NCBI
Build 361611,276,994 - 11,277,838 (-)NCBI Archive
HuRef1611,287,224 - 11,288,068 (-)ENTREZGENE
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
RefSeq Acc Id: NR_104428
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,275,639 - 11,276,480 (-)NCBI
HuRef1611,287,224 - 11,288,068 (-)NCBI
CHM1_11611,369,399 - 11,370,243 (-)NCBI
T2T-CHM13v2.01611,311,859 - 11,312,700 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002753   ⟸   NM_002762
- Peptide Label: isoform 1
- UniProtKB: Q6ZMM0 (UniProtKB/Swiss-Prot),   P04554 (UniProtKB/Swiss-Prot),   Q1LZN1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001273286   ⟸   NM_001286357
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: NP_001273287   ⟸   NM_001286358
- Peptide Label: isoform 4
- UniProtKB: P04554 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273285   ⟸   NM_001286356
- Peptide Label: isoform 2
- UniProtKB: P04554 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001273288   ⟸   NM_001286359
- Peptide Label: isoform 5
- UniProtKB: P04554 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000241808   ⟸   ENST00000241808
RefSeq Acc Id: ENSP00000403681   ⟸   ENST00000435245

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04554-F1-model_v2 AlphaFold P04554 1-102 view protein structure

Promoters
RGD ID:7231333
Promoter ID:EPDNEW_H21412
Type:multiple initiation site
Name:PRM2_1
Description:protamine 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381611,276,480 - 11,276,540EPDNEW
RGD ID:6849424
Promoter ID:EP33038
Type:single initiation site
Name:HS_PRM2
Description:Protamine 2 P2.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 196; Mammalian protamine P2.
Tissues & Cell Lines:spermatids
Experiment Methods:Primer extension; NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361611,277,838 - 11,277,898EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9448 AgrOrtholog
COSMIC PRM2 COSMIC
Ensembl Genes ENSG00000122304 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000241808 ENTREZGENE
  ENST00000241808.9 UniProtKB/Swiss-Prot
  ENST00000435245 ENTREZGENE
  ENST00000435245.2 UniProtKB/Swiss-Prot
GTEx ENSG00000122304 GTEx
HGNC ID HGNC:9448 ENTREZGENE
Human Proteome Map PRM2 Human Proteome Map
InterPro PRM2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5620 UniProtKB/Swiss-Prot
NCBI Gene 5620 ENTREZGENE
OMIM 182890 OMIM
PANTHER PROTAMINE-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR21341 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Protamine_P2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33793 PharmGKB
UniProt D2K905_HUMAN UniProtKB/TrEMBL
  P04554 ENTREZGENE, UniProtKB/Swiss-Prot
  Q1LZN1 ENTREZGENE, UniProtKB/TrEMBL
  Q6ZMM0 ENTREZGENE
UniProt Secondary Q6ZMM0 UniProtKB/Swiss-Prot