Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) - Rat Genome Database

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Gene: Gabra2 (gamma-aminobutyric acid type A receptor subunit alpha 2) Mus musculus
Analyze
Symbol: Gabra2
Name: gamma-aminobutyric acid type A receptor subunit alpha 2
RGD ID: 62148
MGI Page MGI
Description: Predicted to enable GABA-gated chloride ion channel activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Involved in inhibitory synapse assembly. Located in several cellular components, including dendrite; inhibitory synapse; and neuronal cell body. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Is expressed in brain and lens. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C630048P16Rik; GABA(A) receptor subunit alpha-2; Gabr; Gabra-2; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2; gamma-aminobutyric acid receptor subunit alpha-2; MGC140832
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,115,735 - 71,253,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,114,940 - 71,253,192 (-)EnsemblGRCm39 Ensembl
GRCm38570,958,392 - 71,095,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl570,957,597 - 71,095,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv37571,352,296 - 71,487,088 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36571,240,192 - 71,374,984 (-)NCBIMGSCv36mm8
Celera568,229,777 - 68,364,499 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map537.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,2,2-trifluoroethanol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3',5'-cyclic AMP  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Alphaxolone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bicuculline  (ISO)
bisphenol A  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chloral hydrate  (ISO)
Chloralose  (ISO)
chlorobutanol  (ISO)
chlorpyrifos  (EXP,ISO)
Cuprizon  (ISO)
dextran sulfate  (EXP)
diazepam  (EXP,ISO)
dieldrin  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (ISO)
enflurane  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ether  (ISO)
Etizolam  (ISO)
felbamate  (ISO)
fipronil  (ISO)
flunitrazepam  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
isoflurane  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
Lorazepam  (ISO)
maneb  (EXP)
methoxyflurane  (ISO)
oxcarbazepine  (ISO)
paraquat  (EXP)
parathion  (ISO)
pentetrazol  (ISO)
pentobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
progesterone  (ISO)
propofol  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butanol  (ISO)
tert-Butylbicyclophosphorothionate  (ISO)
Testosterone propionate  (EXP)
titanium dioxide  (EXP)
toluene  (ISO)
topiramate  (ISO)
triadimefon  (EXP)
tribromoethanol  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Edenberg HJ, etal., Am J Hum Genet. 2004 Apr;74(4):705-14. Epub 2004 Mar 12.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Ma DQ, etal., Am J Hum Genet. 2005 Sep;77(3):377-88. Epub 2005 Jul 15.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
Additional References at PubMed
PMID:1356407   PMID:1849552   PMID:2561974   PMID:7542761   PMID:7560270   PMID:7713516   PMID:8390964   PMID:8589683   PMID:8889548   PMID:9682826   PMID:9924185   PMID:10022198  
PMID:10349636   PMID:10447508   PMID:10531433   PMID:11021797   PMID:11042159   PMID:11076861   PMID:11331379   PMID:11528422   PMID:12477932   PMID:12588844   PMID:14627650   PMID:14715953  
PMID:14766194   PMID:14990800   PMID:15017002   PMID:15254090   PMID:15304513   PMID:15341600   PMID:15904718   PMID:16101898   PMID:16141072   PMID:16141073   PMID:16291941   PMID:16706856  
PMID:16835366   PMID:16870734   PMID:16874763   PMID:16987237   PMID:17021187   PMID:17698926   PMID:18063661   PMID:18085262   PMID:18202657   PMID:18292084   PMID:18313124   PMID:18973555  
PMID:18985723   PMID:19212922   PMID:19428632   PMID:20133874   PMID:20457185   PMID:20807777   PMID:20876231   PMID:20965216   PMID:21056629   PMID:21073549   PMID:21267068   PMID:21464123  
PMID:21632935   PMID:21722213   PMID:21768381   PMID:21789198   PMID:21825022   PMID:21873635   PMID:21876150   PMID:22506070   PMID:22569571   PMID:22640814   PMID:22666188   PMID:22723691  
PMID:22745509   PMID:22763624   PMID:23067879   PMID:23109109   PMID:23115637   PMID:23147414   PMID:24043839   PMID:24045508   PMID:24481569   PMID:24553732   PMID:24554721   PMID:24948817  
PMID:24952961   PMID:25080596   PMID:25131634   PMID:25708312   PMID:25865415   PMID:26446222   PMID:26971710   PMID:26973458   PMID:27044742   PMID:27129275   PMID:27544825   PMID:27717041  
PMID:27768696   PMID:27819299   PMID:27929372   PMID:28115522   PMID:28137424   PMID:28587819   PMID:28978485   PMID:29069083   PMID:29779941   PMID:30087324   PMID:30104684   PMID:30714905  
PMID:30984232   PMID:31160566   PMID:31665922   PMID:31910261   PMID:32439345   PMID:32620552   PMID:32852103   PMID:33140451   PMID:33154347   PMID:33269700   PMID:34086081   PMID:34321999  
PMID:34408277   PMID:34677900   PMID:34879283   PMID:34994686   PMID:35047853   PMID:35196487   PMID:35228700   PMID:36417873   PMID:36604600   PMID:36604605   PMID:36733270   PMID:37758766  
PMID:38355793  


Genomics

Comparative Map Data
Gabra2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39571,115,735 - 71,253,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl571,114,940 - 71,253,192 (-)EnsemblGRCm39 Ensembl
GRCm38570,958,392 - 71,095,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl570,957,597 - 71,095,849 (-)EnsemblGRCm38mm10GRCm38
MGSCv37571,352,296 - 71,487,088 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36571,240,192 - 71,374,984 (-)NCBIMGSCv36mm8
Celera568,229,777 - 68,364,499 (-)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map537.59NCBI
GABRA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38446,243,548 - 46,390,300 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl446,243,548 - 46,475,230 (-)EnsemblGRCh38hg38GRCh38
GRCh37446,245,565 - 46,392,317 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36445,946,463 - 46,086,702 (-)NCBINCBI36Build 36hg18NCBI36
Build 34446,092,633 - 46,232,873NCBI
Celera446,700,624 - 46,841,051 (-)NCBICelera
Cytogenetic Map4p12NCBI
HuRef445,569,699 - 45,710,166 (-)NCBIHuRef
CHM1_1446,248,463 - 46,389,517 (-)NCBICHM1_1
T2T-CHM13v2.0446,210,399 - 46,357,479 (-)NCBIT2T-CHM13v2.0
Gabra2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81437,451,218 - 37,587,458 (+)NCBIGRCr8
mRatBN7.21437,097,251 - 37,230,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1437,097,279 - 37,228,944 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1437,456,948 - 37,589,716 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01438,761,706 - 38,894,495 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01437,242,647 - 37,375,425 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01439,662,411 - 39,801,082 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1439,661,968 - 39,798,302 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01439,473,078 - 39,610,209 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41439,568,677 - 39,705,897 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11439,574,531 - 39,707,830 (+)NCBI
Celera1436,313,034 - 36,444,629 (+)NCBICelera
Cytogenetic Map14p11NCBI
Gabra2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554432,042,151 - 2,179,174 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554432,042,202 - 2,176,589 (+)NCBIChiLan1.0ChiLan1.0
GABRA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2381,473,905 - 81,625,212 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1481,735,556 - 81,886,702 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0475,762,568 - 75,913,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1486,491,841 - 86,641,878 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl486,491,837 - 86,638,166 (+)Ensemblpanpan1.1panPan2
GABRA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11342,367,988 - 42,488,069 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1342,368,949 - 42,488,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1342,260,942 - 42,439,688 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01342,916,600 - 43,095,420 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1342,973,212 - 43,094,323 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11342,594,633 - 42,773,515 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01342,656,291 - 42,835,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01343,007,629 - 43,186,860 (-)NCBIUU_Cfam_GSD_1.0
Gabra2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528533,613,559 - 33,748,243 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648212,556,585 - 12,682,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648212,555,222 - 12,685,122 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABRA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl836,347,040 - 36,474,627 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1836,344,633 - 36,474,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2838,215,163 - 38,344,937 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABRA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1273,858,741 - 4,013,385 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl273,858,910 - 4,006,582 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604749,925,823 - 50,088,704 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabra2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476120,688,838 - 20,819,568 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476120,688,819 - 20,819,487 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gabra2
4259 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:575
Count of miRNA genes:334
Interacting mature miRNAs:391
Transcripts:ENSMUST00000000572
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301693Sle6_msystemic lupus erythematosus susceptibility 6 (mouse)Not determined5889069387841837Mouse
11341716Rvfs3_mRift Valley fever susceptibility 3 (mouse)526441234138455402Mouse
4140990Lgq6_mlate growth QTL 6 (mouse)Not determined32133234100777931Mouse
4141219W10q16_mweight 10 weeks QTL 16 (mouse)Not determined32133234100777931Mouse
1301524Lmb2_mlupus in MRL and B6 F2 cross (mouse)Not determined537581488112465722Mouse
13464246Ahl11_mage related hearing loss, early onset 11 (mouse)53764377771643896Mouse
1300951Gbvq1_mgallstone bladder volume QTL 1 (mouse)Not determined53811168172111798Mouse
13464245Ahl12_mage related hearing loss, early onset 12 (mouse)53811168172111798Mouse
1301698Pcfm4_mperiosteal circumference and femur length 4 (mouse)Not determined54458584378585965Mouse
13207584Mwmlpt4_mMorris water maze latency to platform, training, 4 (mouse)54632260680322606Mouse
13207588Mwmlpa4_mMorris water maze latency to platform, all, 4 (mouse)54632260680322606Mouse
14746981Manh57_mmandible shape 57 (mouse)54716974281169742Mouse
11041665Lmr24_mleishmaniasis resistance 24 (mouse)552694462107321041Mouse
11041899Lmr24a_mleishmaniasis resistance 24a (mouse)552694462107321041Mouse
4142064Tmc1m4_mTmc1 modifier 4 (mouse)Not determined554500177127001072Mouse
1301243Bmd2_mbone mineral density 2 (mouse)Not determined555388334100455525Mouse
4142317Rgcs1_mretinal ganglion cell susceptible 1 (mouse)Not determined55388334108762627Mouse
13464248Ahl13_mage related hearing loss, early onset 13 (mouse)55564587489645995Mouse
10043962Obq27_mobesity QTL 27 (mouse)Not determined55628565590285655Mouse
10044005Ahl7_mage related hearing loss 7 (mouse)Not determined55833050292330641Mouse
11040591Lmr3c_mleishmaniasis resistance 3c (mouse)55960280193602980Mouse
11040592Lmr3d_mleishmaniasis resistance 3d (mouse)55960280193602980Mouse
11040589Lmr3a_mleishmaniasis resistance 3a (mouse)55960280193602980Mouse
11040590Lmr3b_mleishmaniasis resistance 3b (mouse)55960280193602980Mouse
1301843Listr1_mlisteriosis resistance 1 (mouse)Not determined56024608194246203Mouse
13464247Ahl14_mage related hearing loss, early onset 14 (mouse)56040306294403160Mouse
11252124Modvl6_mmodifier of vacuolated lens 6 (mouse)56265056896650688Mouse
4142428Modvl1_mmodifier of vacuolated lens 1 (mouse)Not determined6265056896650688Mouse
1301010ahl2_mage related hearing loss 2 (mouse)Not determined56265056896650688Mouse
13464250Ahl15_mage related hearing loss, early onset 15 (mouse)56265056896650688Mouse
10045972Tir5_mtrypanosome infection response 5 (mouse)Not determined563705442104387065Mouse
11049560Lmr24d_mleishmaniasis resistance 24d (mouse)56437487798374996Mouse
12904739M2fscn2_mmodifier 2 of FSCN2 (mouse)566529661100529661Mouse
12904740M1fscn2_mmodifier 1 of Fscn2 (mouse)566529661100529661Mouse
26884395Humsd2_mhumerus midshaft diameter 2, 10 week (mouse)570057343132528839Mouse

Markers in Region
M86567  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38570,961,526 - 70,961,646UniSTSGRCm38
MGSCv37571,352,765 - 71,352,885UniSTSGRCm37
Celera568,230,246 - 68,230,366UniSTS
Cytogenetic Map5C3.1UniSTS
Whitehead/MRC_RH5939.64UniSTS
RH109434  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38571,038,993 - 71,039,216UniSTSGRCm38
MGSCv37571,430,232 - 71,430,455UniSTSGRCm37
Celera568,307,696 - 68,307,919UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
Gabra2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37571,352,772 - 71,352,974UniSTSGRCm37
Celera568,230,253 - 68,230,455UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
cM Map540.0UniSTS
D5Buc19  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38571,072,845 - 71,073,067UniSTSGRCm38
MGSCv37571,464,084 - 71,464,306UniSTSGRCm37
Celera568,341,560 - 68,341,782UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
D5Buc15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38570,982,114 - 70,982,328UniSTSGRCm38
MGSCv37571,373,353 - 71,373,567UniSTSGRCm37
Celera568,250,837 - 68,251,051UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
D5Buc16  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38571,025,404 - 71,025,552UniSTSGRCm38
MGSCv37571,416,643 - 71,416,791UniSTSGRCm37
Celera568,294,130 - 68,294,278UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
D5Buc17  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38571,025,417 - 71,025,633UniSTSGRCm38
MGSCv37571,416,656 - 71,416,872UniSTSGRCm37
Celera568,294,143 - 68,294,359UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
Gabra2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS
Gabra2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38570,961,533 - 70,961,735UniSTSGRCm38
MGSCv37571,352,772 - 71,352,974UniSTSGRCm37
Celera568,230,253 - 68,230,455UniSTS
Cytogenetic Map5C3.1UniSTS
cM Map540.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000572   ⟹   ENSMUSP00000000572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,118,404 - 71,251,983 (-)Ensembl
GRCm38.p6 Ensembl570,961,061 - 71,094,640 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197124
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,118,298 - 71,171,027 (-)Ensembl
GRCm38.p6 Ensembl570,960,955 - 71,013,684 (-)Ensembl
RefSeq Acc Id: ENSMUST00000197284   ⟹   ENSMUSP00000142892
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,114,940 - 71,253,192 (-)Ensembl
GRCm38.p6 Ensembl570,957,597 - 71,095,849 (-)Ensembl
RefSeq Acc Id: ENSMUST00000198625   ⟹   ENSMUSP00000143645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,116,824 - 71,253,152 (-)Ensembl
GRCm38.p6 Ensembl570,959,481 - 71,095,809 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,249,093 - 71,252,208 (-)Ensembl
GRCm38.p6 Ensembl571,091,750 - 71,094,865 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl571,130,798 - 71,252,543 (-)Ensembl
GRCm38.p6 Ensembl570,973,455 - 71,095,200 (-)Ensembl
RefSeq Acc Id: NM_008066   ⟹   NP_032092
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39571,115,735 - 71,253,192 (-)NCBI
GRCm38570,958,392 - 71,095,849 (-)NCBI
MGSCv37571,352,296 - 71,487,088 (-)RGD
Celera568,229,777 - 68,364,499 (-)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503733   ⟹   XP_006503796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39571,117,236 - 71,252,844 (-)NCBI
GRCm38570,959,997 - 71,095,506 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_032092   ⟸   NM_008066
- Peptide Label: precursor
- UniProtKB: P26048 (UniProtKB/Swiss-Prot),   Q544G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503796   ⟸   XM_006503733
- Peptide Label: isoform X1
- UniProtKB: P26048 (UniProtKB/Swiss-Prot),   Q544G1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000143645   ⟸   ENSMUST00000198625
RefSeq Acc Id: ENSMUSP00000142892   ⟸   ENSMUST00000197284
RefSeq Acc Id: ENSMUSP00000000572   ⟸   ENSMUST00000000572
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26048-F1-model_v2 AlphaFold P26048 1-451 view protein structure

Promoters
RGD ID:6886834
Promoter ID:EPDNEW_M6868
Type:initiation region
Name:Gabra2_1
Description:Mus musculus gamma-aminobutyric acid A receptor, subunit alpha2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38571,095,807 - 71,095,867EPDNEW
RGD ID:6837550
Promoter ID:MM_KWN:42498
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:NM_008066
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36571,487,156 - 71,487,656 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95614 AgrOrtholog
Ensembl Genes ENSMUSG00000000560 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000572.7 UniProtKB/TrEMBL
  ENSMUST00000197284 ENTREZGENE
  ENSMUST00000197284.5 UniProtKB/Swiss-Prot
  ENSMUST00000198625.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GABAA/Glycine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAAa_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABBAa2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-1-6_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gabra-2_ECD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14395 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:95614 ENTREZGENE
NCBI Gene 14395 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18945:SF218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gabra2 PhenoGen
PRINTS GABAARALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARALPHA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GABAARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JGP5_MOUSE UniProtKB/TrEMBL
  A0A0H2UKB5_MOUSE UniProtKB/TrEMBL
  GBRA2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q544G1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Gabra2  gamma-aminobutyric acid type A receptor subunit alpha 2  Gabra2  gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2  Symbol and/or name change 5135510 APPROVED