Scg2 (secretogranin II) - Rat Genome Database

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Gene: Scg2 (secretogranin II) Rattus norvegicus
Analyze
Symbol: Scg2
Name: secretogranin II
RGD ID: 3626
Description: Predicted to enable chemoattractant activity and cytokine activity. Predicted to be involved in several processes, including eosinophil chemotaxis; induction of positive chemotaxis; and negative regulation of apoptotic process. Located in secretory granule. Orthologous to human SCG2 (secretogranin II); INTERACTS WITH (S)-nicotine; 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Chcg; Chromogranin C (Secretogranin II); chromogranin-C; secretogranin 2; secretogranin II (chromogranin C); secretogranin-2; sgII
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,251,531 - 88,257,208 (-)NCBIGRCr8
mRatBN7.2980,803,074 - 80,808,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,232,915 - 89,238,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,361,806 - 94,367,115 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,744,332 - 92,749,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,237,460 - 85,243,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0984,991,667 - 84,997,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,762,661 - 78,767,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1978,946,079 - 78,951,389 (-)NCBI
Celera978,291,442 - 78,296,748 (-)NCBICelera
Cytogenetic Map9q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenous acid  (ISO)
baclofen  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
captan  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDE  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folpet  (ISO)
glyphosate  (ISO)
lead(0)  (ISO)
methamphetamine  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP)
Oxotremorine  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
potassium chloride  (EXP)
prednisolone  (EXP)
progesterone  (EXP)
propanal  (ISO)
pyrethrins  (EXP)
reserpine  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
thapsigargin  (EXP,ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
chemoattractant activity  (IBA,IEA,ISO,ISS)
cytokine activity  (IBA,IEA,ISO,ISS)
protein binding  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Blanco EH, etal., Neuropeptides. 2011 Aug;45(4):273-9. doi: 10.1016/j.npep.2011.05.002. Epub 2011 May 31.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The primary structure of rat secretogranin II deduced from a cDNA sequence. Gerdes HH, etal., Nucleic Acids Res 1988 Dec 23;16(24):11811.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Differential regulation of chromogranin A, chromogranin B and secretogranin II in rat brain by phencyclidine treatment. Marksteiner J, etal., Neuroscience 2001;104(2):325-33.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Expression of chromogranin/secretogranin mRNA in spontaneous mammary tumors in aging Fischer-344 rats. Umemura S, etal., Pathol Int 2001 Sep;51(9):667-70.
Additional References at PubMed
PMID:1918927   PMID:8321414   PMID:9473216   PMID:9654353   PMID:12534970   PMID:12581877   PMID:12969248   PMID:14622145   PMID:14970115   PMID:15257142   PMID:17962349   PMID:18299326  
PMID:20061385   PMID:20495819   PMID:22655045   PMID:22682498   PMID:24360019   PMID:28902709  


Genomics

Comparative Map Data
Scg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8988,251,531 - 88,257,208 (-)NCBIGRCr8
mRatBN7.2980,803,074 - 80,808,646 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx989,232,915 - 89,238,224 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0994,361,806 - 94,367,115 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0992,744,332 - 92,749,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0985,237,460 - 85,243,024 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0984,991,667 - 84,997,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4978,762,661 - 78,767,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1978,946,079 - 78,951,389 (-)NCBI
Celera978,291,442 - 78,296,748 (-)NCBICelera
Cytogenetic Map9q34NCBI
SCG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,596,940 - 223,602,361 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,596,940 - 223,602,361 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,461,658 - 224,467,079 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,169,902 - 224,175,365 (-)NCBINCBI36Build 36hg18NCBI36
Build 342224,287,231 - 224,292,584NCBI
Celera2218,227,485 - 218,232,948 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2216,313,475 - 216,319,034 (-)NCBIHuRef
CHM1_12224,468,089 - 224,473,648 (-)NCBICHM1_1
T2T-CHM13v2.02224,080,034 - 224,085,455 (-)NCBIT2T-CHM13v2.0
Scg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39179,412,083 - 79,417,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl179,412,386 - 79,417,837 (-)EnsemblGRCm39 Ensembl
GRCm38179,434,366 - 79,440,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl179,434,669 - 79,440,120 (-)EnsemblGRCm38mm10GRCm38
MGSCv37179,431,244 - 79,436,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36179,313,693 - 79,319,114 (-)NCBIMGSCv36mm8
MGSCv36180,309,596 - 80,315,017 (-)NCBIMGSCv36mm8
Cytogenetic Map1C4NCBI
cM Map140.89NCBI
Scg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545310,364,607 - 10,366,466 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545310,361,440 - 10,366,956 (+)NCBIChiLan1.0ChiLan1.0
SCG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213126,223,219 - 126,228,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B126,238,188 - 126,243,628 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B110,849,262 - 110,854,770 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B229,427,169 - 229,432,731 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B229,424,536 - 229,429,510 (-)Ensemblpanpan1.1panPan2
SCG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13729,435,038 - 29,440,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3729,435,041 - 29,437,333 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3730,270,420 - 30,275,988 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03729,459,286 - 29,464,858 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3729,459,232 - 29,464,827 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13729,370,476 - 29,376,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03729,304,406 - 29,309,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03729,314,146 - 29,319,716 (-)NCBIUU_Cfam_GSD_1.0
Scg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303179,024,421 - 179,029,787 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365695,367,206 - 5,373,017 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365695,367,270 - 5,372,627 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15125,419,847 - 125,426,278 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115125,420,773 - 125,426,303 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SCG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110109,505,344 - 109,510,830 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604089,869,948 - 89,875,489 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248231,659,431 - 1,661,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248231,656,195 - 1,661,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Scg2
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:128
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000020219
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)97927151191616855Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)97927151191616855Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat

Markers in Region
D9Wox33  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,809,229 - 80,809,441 (+)MAPPERmRatBN7.2
Rnor_6.0985,243,608 - 85,243,817NCBIRnor6.0
Rnor_5.0984,997,815 - 84,998,024UniSTSRnor5.0
RGSC_v3.4978,768,736 - 78,768,945UniSTSRGSC3.4
Celera978,297,514 - 78,297,723UniSTS
Cytogenetic Map9q34UniSTS
Scg2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,803,814 - 80,804,754 (+)MAPPERmRatBN7.2
Rnor_6.0985,238,201 - 85,239,140NCBIRnor6.0
Rnor_5.0984,992,408 - 84,993,347UniSTSRnor5.0
RGSC_v3.4978,763,325 - 78,764,264UniSTSRGSC3.4
Celera978,292,106 - 78,293,045UniSTS
Cytogenetic Map9q34UniSTS
RH139367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,803,262 - 80,803,449 (+)MAPPERmRatBN7.2
Rnor_6.0985,237,649 - 85,237,835NCBIRnor6.0
Rnor_5.0984,991,856 - 84,992,042UniSTSRnor5.0
RGSC_v3.4978,762,773 - 78,762,959UniSTSRGSC3.4
Celera978,291,554 - 78,291,740UniSTS
RH 3.4 Map9734.2UniSTS
Cytogenetic Map9q34UniSTS
Scg2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2980,808,475 - 80,808,577 (+)MAPPERmRatBN7.2
Rnor_6.0985,242,854 - 85,242,955NCBIRnor6.0
Rnor_5.0984,997,061 - 84,997,162UniSTSRnor5.0
RGSC_v3.4978,767,982 - 78,768,083UniSTSRGSC3.4
Celera978,296,760 - 78,296,861UniSTS
Cytogenetic Map9q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 60 1
Low 12 1 2 2 12 21 33 6 2
Below cutoff 26 24 16 15 16 5 5 2 14 7 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020219   ⟹   ENSRNOP00000020219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,803,075 - 80,808,502 (-)Ensembl
Rnor_6.0 Ensembl985,237,458 - 85,243,001 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105728   ⟹   ENSRNOP00000078659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,803,075 - 80,811,332 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112421   ⟹   ENSRNOP00000089801
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl980,803,075 - 80,821,097 (-)Ensembl
RefSeq Acc Id: NM_022669   ⟹   NP_073160
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,557 - 88,256,866 (-)NCBI
mRatBN7.2980,803,151 - 80,808,464 (-)NCBI
Rnor_6.0985,237,537 - 85,242,842 (-)NCBI
Rnor_5.0984,991,667 - 84,997,231 (-)NCBI
RGSC_v3.4978,762,661 - 78,767,970 (-)RGD
Celera978,291,442 - 78,296,748 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245148   ⟹   XP_006245210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,257,208 (-)NCBI
mRatBN7.2980,803,074 - 80,808,646 (-)NCBI
Rnor_6.0985,237,460 - 85,243,024 (-)NCBI
Rnor_5.0984,991,667 - 84,997,231 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767195   ⟹   XP_008765417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,256,974 (-)NCBI
mRatBN7.2980,803,125 - 80,808,606 (-)NCBI
Rnor_6.0985,237,511 - 85,243,012 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266647   ⟹   XP_063122717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8988,251,531 - 88,256,983 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_073160   ⟸   NM_022669
- Peptide Label: precursor
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   A0A8I6A821 (UniProtKB/TrEMBL),   A6JW74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245210   ⟸   XM_006245148
- Peptide Label: isoform X2
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   G3V7X2 (UniProtKB/TrEMBL),   Q6P7R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765417   ⟸   XM_008767195
- Peptide Label: isoform X1
- UniProtKB: P10362 (UniProtKB/Swiss-Prot),   A0A8I6A821 (UniProtKB/TrEMBL),   A6JW74 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020219   ⟸   ENSRNOT00000020219
RefSeq Acc Id: ENSRNOP00000078659   ⟸   ENSRNOT00000105728
RefSeq Acc Id: ENSRNOP00000089801   ⟸   ENSRNOT00000112421
RefSeq Acc Id: XP_063122717   ⟸   XM_063266647
- Peptide Label: isoform X2
- UniProtKB: G3V7X2 (UniProtKB/TrEMBL),   Q6P7R4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10362-F1-model_v2 AlphaFold P10362 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696790
Promoter ID:EPDNEW_R7314
Type:multiple initiation site
Name:Scg2_1
Description:secretogranin II
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0985,242,893 - 85,242,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3626 AgrOrtholog
BioCyc Gene G2FUF-27015 BioCyc
Ensembl Genes ENSRNOG00000015055 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020219.4 UniProtKB/TrEMBL
  ENSRNOT00000105728.1 UniProtKB/TrEMBL
  ENSRNOT00000112421.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6919444 IMAGE-MGC_LOAD
InterPro Chromogranin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Granin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ScgII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24765 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72816 IMAGE-MGC_LOAD
NCBI Gene 24765 ENTREZGENE
PANTHER PTHR15119 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SECRETOGRANIN-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Granin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Scg2 PhenoGen
PROSITE GRANINS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015055 RatGTEx
UniProt A0A8I6A821 ENTREZGENE, UniProtKB/TrEMBL
  A6JW71_RAT UniProtKB/TrEMBL
  A6JW74 ENTREZGENE, UniProtKB/TrEMBL
  A6JW75_RAT UniProtKB/TrEMBL
  G3V7X2 ENTREZGENE, UniProtKB/TrEMBL
  P10362 ENTREZGENE
  Q6P7R4 ENTREZGENE
  SCG2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6P7R4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Scg2  secretogranin II  Scg2  secretogranin II (chromogranin C)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Scg2  secretogranin II (chromogranin C)  Scg2  secretogranin II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-20 Scg2  secretogranin II  Scg2  secretogranin 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Scg2  secretogranin 2      Symbol and Name updated 629477 APPROVED
2003-03-06 Scg2  secretogranin 2  Chcg  Chromogranin C (Secretogranin II)  Data merged from RGD:2337 628472 PROVISIONAL
2002-06-10 Chcg  Chromogranin C (Secretogranin II)      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Scg2  Secretogranin II      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA is expressed in some mammary tumors 727329