Pom121l2 (POM121 transmembrane nucleoporin like 2) - Rat Genome Database

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Gene: Pom121l2 (POM121 transmembrane nucleoporin like 2) Mus musculus
Analyze
Symbol: Pom121l2
Name: POM121 transmembrane nucleoporin like 2
RGD ID: 2311283
MGI Page MGI
Description: Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. Orthologous to human POM121L2 (POM121 transmembrane nucleoporin like 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm24; POM121 membrane glycoprotein-like 2; POM121 membrane glycoprotein-like 2 (rat); POM121-like protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391322,165,351 - 22,172,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1322,165,364 - 22,172,904 (+)EnsemblGRCm39 Ensembl
GRCm381321,981,181 - 21,988,734 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,981,194 - 21,988,734 (+)EnsemblGRCm38mm10GRCm38
MGSCv371322,073,050 - 22,080,603 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361321,988,646 - 21,996,199 (+)NCBIMGSCv36mm8
Celera1322,253,113 - 22,260,670 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map138.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear pore  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:14610273   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  


Genomics

Comparative Map Data
Pom121l2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391322,165,351 - 22,172,904 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1322,165,364 - 22,172,904 (+)EnsemblGRCm39 Ensembl
GRCm381321,981,181 - 21,988,734 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1321,981,194 - 21,988,734 (+)EnsemblGRCm38mm10GRCm38
MGSCv371322,073,050 - 22,080,603 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361321,988,646 - 21,996,199 (+)NCBIMGSCv36mm8
Celera1322,253,113 - 22,260,670 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map138.11NCBI
POM121L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38627,308,377 - 27,312,273 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl627,285,903 - 27,312,273 (-)EnsemblGRCh38hg38GRCh38
GRCh37627,276,156 - 27,280,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36627,384,821 - 27,388,776 (-)NCBINCBI36Build 36hg18NCBI36
Celera628,882,843 - 28,886,012 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef627,084,731 - 27,087,900 (-)NCBIHuRef
CHM1_1627,279,168 - 27,282,337 (-)NCBICHM1_1
T2T-CHM13v2.0627,177,485 - 27,181,380 (-)NCBIT2T-CHM13v2.0
Pom121l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81747,241,917 - 47,249,231 (-)NCBIGRCr8
mRatBN7.21742,546,144 - 42,553,447 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1742,546,326 - 42,553,423 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1744,595,965 - 44,603,240 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01749,355,040 - 49,362,319 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01743,845,984 - 43,853,265 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01744,588,022 - 44,595,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,588,045 - 44,595,323 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01758,875,434 - 58,882,517 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41750,179,184 - 50,186,917 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1753,907,490 - 53,915,480 (+)NCBICelera
Cytogenetic Map17p11NCBI
Pom121l2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546513,175,383 - 13,178,722 (-)NCBIChiLan1.0ChiLan1.0
LOC100979681
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2541,953,771 - 41,957,571 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1637,955,299 - 37,959,099 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0627,141,342 - 27,145,132 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1627,817,665 - 27,820,859 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl627,817,665 - 27,820,772 (-)Ensemblpanpan1.1panPan2
LOC611386
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13524,672,617 - 24,682,277 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3524,528,715 - 24,538,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03526,883,577 - 26,893,693 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13524,635,600 - 24,645,544 (-)NCBIUMICH_Zoey_3.1
LOC110599301
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946709,301 - 713,815 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366712,909,132 - 2,912,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POM121L2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1721,337,402 - 21,344,185 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2722,694,415 - 22,699,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POM121L2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11745,208,541 - 45,213,032 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1745,209,508 - 45,212,612 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604426,994,612 - 26,998,614 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pom121l2
388 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:507
Count of miRNA genes:353
Interacting mature miRNAs:407
Transcripts:ENSMUST00000017126, ENSMUST00000117882
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301890Adip7_madiposity 7 (mouse)Not determined13123454672Mouse
1301227Skull19_mskull morphology 19 (mouse)Not determined13123454672Mouse
1301661Tshp13_mtooth shape 13 (mouse)Not determined13123454672Mouse
1301255Cd4ts6_mCD4 T cell subset 6 (mouse)Not determined1316854534168684Mouse
10449140Eosn2_meosinophil differential 2 (mouse)1322131134221311Mouse
15039338Nmrs34_mNAFLD-associated magnetic resonance shift 34 (mouse)1322131134221311Mouse
1301455Bmd3_mbone mineral density 3 (mouse)Not determined13347761237477820Mouse
10045624Heal24_mwound healing/regeneration (mouse)Not determined13347761237477820Mouse
10045625Heal23_mwound healing/regeneration 23 (mouse)Not determined13347761237477820Mouse
1301367Twq1_mtestis weight QTL 1 (mouse)Not determined13361551237615672Mouse
1301733Heal3_mwound healing/regeneration 3 (mouse)Not determined13368020037680343Mouse
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
1558898Hpi1_mhapatic PMN infiltration 1 (mouse)Not determined13441402553101640Mouse
10402494Igmsc1_mimmunoglobulin M secreting cells 1 (mouse)Not determined131716854544918560Mouse
1301984Pbd2_mpeak bone density 2 (mouse)Not determined131718950838947406Mouse
1301880Hypt_mhypertension (mouse)Not determined131815679252156924Mouse
13463469Gssq1_mglomerulosclerosis severity QTL 1 (mouse)131906090853061050Mouse
12880423V25Dq7_mvitamin D inactive form serum level QTL 7 (mouse)131958398353583983Mouse
1301015Sysbp2_msystolic blood pressure 2 (mouse)Not determined132047761259821605Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1357591Tesq1_mtestis weight QTL 1 (mouse)Not determined132061551255720517Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10045618Heal17_mwound healing/regeneration 17 (mouse)Not determined132074693954747056Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000017126   ⟹   ENSMUSP00000017126
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1322,165,690 - 22,168,649 (+)Ensembl
GRCm38.p6 Ensembl1321,981,520 - 21,984,479 (+)Ensembl
RefSeq Acc Id: ENSMUST00000117882   ⟹   ENSMUSP00000113688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1322,165,364 - 22,172,904 (+)Ensembl
GRCm38.p6 Ensembl1321,981,194 - 21,988,734 (+)Ensembl
RefSeq Acc Id: NM_001162928   ⟹   NP_001156400
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391322,165,351 - 22,170,077 (+)NCBI
GRCm381321,981,181 - 21,985,907 (+)NCBI
MGSCv371322,073,050 - 22,080,603 (+)RGD
Celera1322,253,113 - 22,260,670 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001162929   ⟹   NP_001156401
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391322,165,364 - 22,172,904 (+)NCBI
GRCm381321,981,194 - 21,988,734 (+)NCBI
MGSCv371322,073,050 - 22,080,603 (+)RGD
Celera1322,253,113 - 22,260,670 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001156400   ⟸   NM_001162928
- Peptide Label: isoform 1
- UniProtKB: Q5SW25 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156401   ⟸   NM_001162929
- Peptide Label: isoform 2
- UniProtKB: Q3V0N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000017126   ⟸   ENSMUST00000017126
RefSeq Acc Id: ENSMUSP00000113688   ⟸   ENSMUST00000117882

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5SW25-F1-model_v2 AlphaFold Q5SW25 1-972 view protein structure

Promoters
RGD ID:8679750
Promoter ID:EPDNEW_M17906
Type:initiation region
Name:Pom121l2_1
Description:Mus musculus POM121 membrane glycoprotein-like 2 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381321,981,476 - 21,981,536EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684870 AgrOrtholog
Ensembl Genes ENSMUSG00000016982 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000017126 ENTREZGENE
  ENSMUST00000017126.6 UniProtKB/Swiss-Prot
  ENSMUST00000117882 ENTREZGENE
  ENSMUST00000117882.2 UniProtKB/TrEMBL
InterPro Nucleoporin UniProtKB/Swiss-Prot
KEGG Report mmu:195236 UniProtKB/Swiss-Prot
MGD MGI:2684870 ENTREZGENE
NCBI Gene 195236 ENTREZGENE
PANTHER POM121-LIKE PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR23193 UniProtKB/Swiss-Prot
Pfam POM121 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pom121l2 PhenoGen
UniProt P12L2_MOUSE UniProtKB/Swiss-Prot
  Q3V0N0 ENTREZGENE, UniProtKB/TrEMBL
  Q5SW25 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-21 Pom121l2  POM121 transmembrane nucleoporin like 2  Pom121l2  POM121 membrane glycoprotein-like 2 (rat)  Symbol and/or name change 5135510 APPROVED