Pde6h (phosphodiesterase 6H) - Rat Genome Database

Name: Pde6h
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Pde6h (phosphodiesterase 6H) Heterocephalus glaber

Analyze

Symbol:

Pde6h

Name:

phosphodiesterase 6H

RGD ID:

18936277

Description:

INVOLVED IN positive regulation of epidermal growth factor receptor signaling pathway (ortholog); positive regulation of G protein-coupled receptor signaling pathway (ortholog); positive regulation of MAPK cascade (ortholog); PARTICIPATES IN visual phototransduction pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder 6 (ortholog); color blindness (ortholog); cone-rod dystrophy 14 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PDE6H (phosphodiesterase 6H)	NCBI	Ortholog
Mus musculus (house mouse):	Pde6h (phosphodiesterase 6H, cGMP-specific, cone, gamma)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Pde6h (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pde6h (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PDE6H (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PDE6H (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pde6h (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PDE6H (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PDE6H (phosphodiesterase 6H)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	23,051,752 - 23,055,103 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	23,051,486 - 23,055,128 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 6 (ISO)

color blindness (ISO)

cone-rod dystrophy 14 (ISO)

retinal cone dystrophy 3A (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of epidermal growth factor receptor signaling pathway (ISO)

positive regulation of G protein-coupled receptor signaling pathway (ISO)

positive regulation of MAPK cascade (ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

visual phototransduction pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pde6h
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	23,051,752 - 23,055,103 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	23,051,486 - 23,055,128 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

PDE6H
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	14,973,042 - 14,981,865 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	14,973,042 - 14,981,865 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	15,125,976 - 15,134,799 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	15,017,245 - 15,026,066 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	15,017,244 - 15,026,066	NCBI
Celera	12	20,270,954 - 20,279,795 (+)	NCBI		Celera
Cytogenetic Map	12	p12.3	NCBI
HuRef	12	14,895,337 - 14,904,178 (+)	NCBI		HuRef
CHM1_1	12	15,092,057 - 15,100,898 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	14,850,375 - 14,859,197 (+)	NCBI		T2T-CHM13v2.0

Pde6h
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	136,929,216 - 136,940,483 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	136,900,830 - 136,945,863 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	136,952,218 - 136,963,485 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	136,923,832 - 136,968,865 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	136,903,044 - 136,912,004 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	136,918,719 - 136,927,678 (+)	NCBI		MGSCv36	mm8
Celera	6	139,997,648 - 140,006,582 (+)	NCBI		Celera
Cytogenetic Map	6	G1	NCBI
cM Map	6	66.72	NCBI

Pde6h
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	171,588,896 - 171,604,142 (+)	NCBI		GRCr8
mRatBN7.2	4	169,857,793 - 169,872,969 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	169,857,812 - 169,872,969 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	176,164,525 - 176,169,238 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	171,944,657 - 171,949,411 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	170,570,202 - 170,574,915 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	170,947,723 - 170,963,046 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	170,958,196 - 170,963,046 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	235,204,371 - 235,219,664 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	174,009,860 - 174,014,405 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	174,254,983 - 174,259,529 (+)	NCBI
Celera	4	158,449,142 - 158,453,876 (+)	NCBI		Celera
Cytogenetic Map	4	q43	NCBI

Pde6h
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	11,703,378 - 11,712,075 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	11,654,252 - 11,711,799 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDE6H
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	20,254,398 - 20,430,243 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	20,285,815 - 20,427,004 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	14,890,192 - 14,984,542 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	15,372,413 - 15,381,249 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	15,372,413 - 15,381,249 (+)	Ensembl	panpan1.1		panPan2

PDE6H
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	31,640,731 - 31,664,494 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	31,640,737 - 31,664,401 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	14,784,654 - 14,808,356 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	31,947,405 - 31,970,923 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	31,947,411 - 31,970,880 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	31,836,788 - 31,860,326 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	31,795,045 - 31,818,763 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	14,516,903 - 14,540,640 (+)	NCBI		UU_Cfam_GSD_1.0

Pde6h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	92,778,204 - 92,786,504 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936587	2,506,585 - 2,514,157 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936587	2,505,755 - 2,514,103 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDE6H
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	57,556,149 - 57,594,423 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	57,555,448 - 57,582,324 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	60,944,506 - 60,978,007 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDE6H
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	14,869,864 - 14,880,307 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	14,870,498 - 14,880,324 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	20,430,389 - 20,439,864 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004845826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01033203	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000023280 ⟹ ENSHGLP00000023065

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624752	23,051,752 - 23,055,103 (-)	Ensembl

RefSeq Acc Id:

ENSHGLT00000023281 ⟹ ENSHGLP00000023066

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624752	23,051,777 - 23,055,103 (-)	Ensembl

RefSeq Acc Id:

XM_004845826 ⟹ XP_004845883

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624752	23,051,486 - 23,055,128 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_004845883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000023065

RefSeq Acc Id:

XP_004845883 ⟸ XM_004845826

RefSeq Acc Id:

ENSHGLP00000023066 ⟸ ENSHGLT00000023281

RefSeq Acc Id:

ENSHGLP00000023065 ⟸ ENSHGLT00000023280

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000016447	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000023280	ENTREZGENE
NCBI Gene	Pde6h	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations