Aicda (activation induced cytidine deaminase)

Gene: Aicda (activation induced cytidine deaminase) Heterocephalus glaber

Analyze

Symbol:

Aicda

Name:

activation induced cytidine deaminase

RGD ID:

18934249

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); defense response to bacterium (ortholog); isotype switching (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); Alphavirus Infections (ortholog); autoimmune disease (ortholog); FOUND IN protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

single-stranded DNA cytosine deaminase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	4,912,656 - 4,926,634 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	4,912,938 - 4,927,846 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

Alphavirus Infections (ISO)

autoimmune disease (ISO)

B-Cell Chronic Lymphocytic Leukemia (ISO)

B-cell lymphoma (ISO)

Blast Crisis (ISO)

Chronic Hepatitis C (ISO)

cryoglobulinemic vasculitis (ISO)

developmental and epileptic encephalopathy 21 (ISO)

Epstein-Barr virus infectious disease (ISO)

gastritis (ISO)

genetic disease (ISO)

Helicobacter Infections (ISO)

hepatitis B (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

hyper IgM syndrome (ISO)

hyperimmunoglobulin syndrome (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

immunodeficiency with hyper-IgM type 2 (ISO)

Klippel-Feil syndrome 3 (ISO)

Lymphatic Metastasis (ISO)

lymphoid leukemia (ISO)

Lymphoma, AIDS-Related (ISO)

lymphoproliferative syndrome 2 (ISO)

malaria (ISO)

peroxisome biogenesis disorder 2B (ISO)

plasmacytoma (ISO)

Pneumococcal Pneumonia (ISO)

Polyomavirus Infections (ISO)

respiratory syncytial virus infectious disease (ISO)

Retroviridae Infections (ISO)

Salmonella Infections, Animal (ISO)

Strongylida Infections (ISO)

swine influenza (ISO)

T-cell non-Hodgkin lymphoma (ISO)

Temtamy syndrome (ISO)

visceral leishmaniasis (ISO)

X-linked hyper IgM syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (ISO)

cytidine deamination (IEA)

cytidine to uridine editing (IEA)

defense response to bacterium (ISO)

defense response to virus (IEA)

DNA cytosine deamination (IEA)

isotype switching (ISO)

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate (IEA)

obsolete DNA demethylation (IEA)

positive regulation of gene expression via chromosomal CpG island demethylation (ISO)

regulation of nuclear cell cycle DNA replication (ISO)

somatic diversification of immunoglobulins (ISO)

somatic hypermutation of immunoglobulin genes (ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

P-body (IEA)

protein-containing complex (ISO)

Molecular Function

cytidine deaminase activity (IEA)

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines (IEA)

identical protein binding (ISO)

metal ion binding (IEA)

obsolete deoxycytidine deaminase activity (IEA)

protein binding (ISO)

RNA binding (IEA)

ubiquitin protein ligase binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-4 signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Aicda
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	4,912,656 - 4,926,634 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	4,912,938 - 4,927,846 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

AICDA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	8,602,170 - 8,612,859 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	8,602,155 - 8,613,242 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	8,754,766 - 8,765,455 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	8,646,029 - 8,656,706 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	8,646,028 - 8,656,706	NCBI
Celera	12	10,292,343 - 10,303,027 (-)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	8,537,559 - 8,548,246 (-)	NCBI		HuRef
CHM1_1	12	8,723,739 - 8,734,421 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	8,585,624 - 8,596,319 (-)	NCBI		T2T-CHM13v2.0

Aicda
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	122,530,768 - 122,541,139 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	122,530,760 - 122,541,139 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	122,553,809 - 122,564,180 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	122,553,801 - 122,564,180 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	122,503,827 - 122,514,198 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	122,519,428 - 122,529,798 (+)	NCBI		MGSCv36	mm8
Celera	6	124,348,050 - 124,358,431 (+)	NCBI		Celera
Cytogenetic Map	6	F1	NCBI
cM Map	6	57.65	NCBI

Aicda
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	157,446,120 - 157,455,958 (+)	NCBI		GRCr8
mRatBN7.2	4	155,774,132 - 155,783,972 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	155,774,132 - 155,783,972 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	162,037,288 - 162,047,024 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	157,820,509 - 157,830,246 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	156,467,264 - 156,476,977 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	155,359,909 - 155,371,104 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	155,359,921 - 155,369,671 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	222,384,433 - 222,395,569 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	159,006,328 - 159,017,501 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	159,257,307 - 159,260,429 (+)	NCBI
Celera	4	144,595,276 - 144,605,030 (+)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

AICDA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	14,130,168 - 14,140,777 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	14,126,928 - 14,137,537 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	8,688,392 - 8,699,008 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	8,903,288 - 8,913,895 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	8,904,273 - 8,913,917 (-)	Ensembl	panpan1.1		panPan2

AICDA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	37,064,107 - 37,073,791 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	37,064,080 - 37,073,789 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	9,542,544 - 9,552,236 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	37,413,568 - 37,423,269 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	37,413,475 - 37,423,284 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	37,294,310 - 37,303,981 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	37,329,570 - 37,339,245 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	9,029,099 - 9,038,784 (-)	NCBI		UU_Cfam_GSD_1.0

Aicda
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	98,736,851 - 98,746,413 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936870	25,039 - 34,601 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936870	25,039 - 34,601 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AICDA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	62,777,352 - 62,787,369 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	62,777,236 - 62,787,342 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	65,607,510 - 65,617,612 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AICDA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	8,426,920 - 8,438,331 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	8,428,922 - 8,431,641 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666089	515,359 - 525,346 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004869540	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01093210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01093211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01093212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01093213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSHGLT00000001936 ⟹ ENSHGLP00000001890

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624860	4,912,656 - 4,926,634 (+)	Ensembl

RefSeq Acc Id:

ENSHGLT00000001937 ⟹ ENSHGLP00000001891

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624860	4,912,938 - 4,926,634 (+)	Ensembl

RefSeq Acc Id:

XM_004869540 ⟹ XP_004869597

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624860	4,912,938 - 4,927,846 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004869597	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000001891

RefSeq Acc Id:	XP_004869597 ⟸ XM_004869540
- UniProtKB:	G5BPM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSHGLP00000001890 ⟸ ENSHGLT00000001936

RefSeq Acc Id:

ENSHGLP00000001891 ⟸ ENSHGLT00000001937

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000001443	Ensembl, ENTREZGENE
Ensembl Transcript	ENSHGLT00000001937	ENTREZGENE
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/TrEMBL
InterPro	APOBEC/CMP_deaminase_Zn-bd	UniProtKB/TrEMBL
	APOBEC_N	UniProtKB/TrEMBL
	CMP_dCMP_dom	UniProtKB/TrEMBL
	Cytidine_deaminase-like	UniProtKB/TrEMBL
NCBI Gene	Aicda	ENTREZGENE
PANTHER	MRNA EDITING ENZYME	UniProtKB/TrEMBL
	SINGLE-STRANDED DNA CYTOSINE DEAMINASE	UniProtKB/TrEMBL
Pfam	APOBEC_N	UniProtKB/TrEMBL
PROSITE	CYT_DCMP_DEAMINASES_1	UniProtKB/TrEMBL
	CYT_DCMP_DEAMINASES_2	UniProtKB/TrEMBL
Superfamily-SCOP	Cytidine deaminase-like	UniProtKB/TrEMBL
UniProt	G5BPM7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)