RGD Reference Report - Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas. - Rat Genome Database

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Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas.

Authors: Matsushita, Michiko  Iwasaki, Takeshi  Nonaka, Daisuke  Kuwamoto, Satoshi  Nagata, Keiko  Kato, Masako  Kitamura, Yukisato  Hayashi, Kazuhiko 
Citation: Matsushita M, etal., Yonago Acta Med. 2017 Sep 15;60(3):145-153. eCollection 2017 Sep.
RGD ID: 30310234
Pubmed: PMID:28959124   (View Abstract at PubMed)
PMCID: PMC5611468   (View Article at PubMed Central)


BACKGROUND: Merkel cell carcinomas (MCCs), clinically aggressive neuroendocrine skin cancers, are divided into Merkel cell polyomavirus (MCPyV)-positive and -negative tumors, which show different clinicopathological features and may develop through different mechanisms of carcinogenesis. Aberrant expression of activation-induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen-related NF-κB signal in Helicobacter pylori-associated gastric cancer, adult T cell leukemia/lymphoma (HTLV-1), hepatoma (HCV), and Burkitt lymphoma (EBV).
METHODS: To elucidate the relation of aberrant AID expression in MCPyV-positive and -negative MCCs, we evaluated immunohistochemical expressions of AID and AID-regulating factors between 24 MCPyV-positive and 17 MCPyV-negative MCCs.
RESULTS: AID expression was significantly higher in MCPyV-negative MCCs than MCPyV-positive ones (P = 0.026), although expression of NF-κB p65 (phospho S536) (AID-enhancer) was significantly higher in MCPyV-positive MCCs than MCPyV-negative ones (P = 0.034). Expressions of PAX5 and c-Myb were not significantly different between these subgroups. Expressions of AID and AID-regulating factors were not correlated to prognosis of MCC patients.
CONCLUSION: Our findings suggest that although pathogen-induced AID expression through upregulation of NF-κB may be relevant to carcinogenesis of MCPyV-positive MCCs, the significantly higher aberrant AID expression in MCPyV-negative MCCs is consistent with the fact that MCPyV-negative MCCs have an extremely higher mutation burden than MCPyV-positive ones.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AICDAHumanPolyomavirus Infections  IEP associated with Merkel cell carcinoma and protein:decreased expression::RGD 
AicdaRatPolyomavirus Infections  ISOAICDA (Homo sapiens)associated with Merkel cell carcinoma and protein:decreased expression::RGD 
AicdaMousePolyomavirus Infections  ISOAICDA (Homo sapiens)associated with Merkel cell carcinoma and protein:decreased expression::RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aicda  (activation-induced cytidine deaminase)

Genes (Mus musculus)
Aicda  (activation-induced cytidine deaminase)

Genes (Homo sapiens)
AICDA  (activation induced cytidine deaminase)


Additional Information