Alpl (alkaline phosphatase, biomineralization associated) - Rat Genome Database

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Gene: Alpl (alkaline phosphatase, biomineralization associated) Heterocephalus glaber
Analyze
Symbol: Alpl
Name: alkaline phosphatase, biomineralization associated
RGD ID: 18929207
Description: ENCODES a protein that exhibits alkaline phosphatase activity (ortholog); calcium ion binding (ortholog); phosphoamidase activity (ortholog); INVOLVED IN bone mineralization (ortholog); calcium ion homeostasis (ortholog); cellular homeostasis (ortholog); PARTICIPATES IN hypophosphatasia pathway; vitamin B6 metabolic pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); adult hypophosphatasia (ortholog); Alveolar Bone Loss (ortholog); FOUND IN extracellular matrix (ortholog); extracellular membrane-bounded organelle (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase, tissue-nonspecific isozyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,393,765 - 6,447,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Alpl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247646,393,765 - 6,447,829 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ALPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38121,508,984 - 21,578,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl121,509,397 - 21,578,410 (+)EnsemblGRCh38hg38GRCh38
GRCh37121,835,477 - 21,904,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36121,708,445 - 21,777,492 (+)NCBINCBI36Build 36hg18NCBI36
Build 34121,581,174 - 21,650,208NCBI
Celera120,158,568 - 20,227,624 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,079,620 - 20,148,672 (+)NCBIHuRef
CHM1_1121,947,891 - 22,016,920 (+)NCBICHM1_1
T2T-CHM13v2.0121,332,916 - 21,402,323 (+)NCBIT2T-CHM13v2.0
Alpl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,469,042 - 137,523,695 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,469,044 - 137,523,695 (-)EnsemblGRCm39 Ensembl
GRCm384137,741,731 - 137,796,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,741,733 - 137,796,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv374137,297,647 - 137,352,292 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364137,013,815 - 137,068,399 (-)NCBIMGSCv36mm8
Celera4135,949,159 - 136,007,413 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map470.02NCBI
Alpl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85155,234,770 - 155,289,785 (-)NCBIGRCr8
mRatBN7.25149,951,397 - 150,006,424 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,951,409 - 150,006,446 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,647,183 - 152,702,235 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,421,476 - 154,476,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,403,485 - 154,458,535 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05156,086,496 - 156,141,513 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5156,086,497 - 156,141,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,841,916 - 159,897,391 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,501,739 - 156,558,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,511,778 - 156,568,766 (-)NCBI
Celera5148,347,371 - 148,402,292 (-)NCBICelera
RH 3.4 Map51009.6RGD
Cytogenetic Map5q36NCBI
Alpl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554521,820,174 - 1,874,226 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554521,820,212 - 1,873,877 (+)NCBIChiLan1.0ChiLan1.0
ALPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21205,360,590 - 205,430,382 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11204,472,488 - 204,542,348 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0120,702,509 - 20,772,301 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1121,667,732 - 21,736,688 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl121,667,732 - 21,736,688 (+)Ensemblpanpan1.1panPan2
ALPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,559,791 - 77,614,102 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,559,791 - 77,614,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha274,073,609 - 74,088,831 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0278,128,381 - 78,182,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl278,128,381 - 78,182,455 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1274,947,430 - 74,962,684 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0275,958,433 - 75,973,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0276,961,389 - 76,976,632 (-)NCBIUU_Cfam_GSD_1.0
Alpl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,362,174 - 41,405,120 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364747,209,093 - 7,229,989 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364747,209,196 - 7,229,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl679,589,045 - 79,649,644 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1679,589,695 - 79,649,646 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ALPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120111,055,583 - 111,124,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20111,055,558 - 111,081,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,163,162 - 5,231,388 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000014283   ⟹   ENSHGLP00000014140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247646,393,765 - 6,447,829 (+)Ensembl
RefSeq Acc Id: XM_004850506   ⟹   XP_004850563
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247646,393,741 - 6,447,739 (+)NCBI
RefSeq Acc Id: XM_013074427   ⟹   XP_012929881
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247646,434,565 - 6,447,739 (+)NCBI
RefSeq Acc Id: XM_021263002   ⟹   XP_021118661
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247646,420,928 - 6,447,739 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004850563 (Get FASTA)   NCBI Sequence Viewer  
  XP_012929881 (Get FASTA)   NCBI Sequence Viewer  
  XP_021118661 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB08921 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014140
GenBank Protein JAO02288 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004850563   ⟸   XM_004850506
- Peptide Label: isoform X1
- UniProtKB: G5BI10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021118661   ⟸   XM_021263002
- Peptide Label: isoform X1
- UniProtKB: G5BI10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012929881   ⟸   XM_013074427
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000014140   ⟸   ENSHGLT00000014283


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010100 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000014283 ENTREZGENE
Gene3D-CATH 3.40.720.10 UniProtKB/TrEMBL
InterPro Alkaline_phosphatase UniProtKB/TrEMBL
  Alkaline_phosphatase_AS UniProtKB/TrEMBL
  Alkaline_phosphatase_core_sf UniProtKB/TrEMBL
KEGG Report hgl:101725910 UniProtKB/TrEMBL
NCBI Gene Alpl ENTREZGENE
PANTHER ALKALINE PHOSPHATASE, TISSUE-NONSPECIFIC ISOZYME UniProtKB/TrEMBL
  PTHR11596 UniProtKB/TrEMBL
Pfam Alk_phosphatase UniProtKB/TrEMBL
PRINTS ALKPHPHTASE UniProtKB/TrEMBL
PROSITE ALKALINE_PHOSPHATASE UniProtKB/TrEMBL
SMART alkPPc UniProtKB/TrEMBL
Superfamily-SCOP SSF53649 UniProtKB/TrEMBL
UniProt G5BI10 ENTREZGENE, UniProtKB/TrEMBL