Ide (insulin degrading enzyme) - Rat Genome Database

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Gene: Ide (insulin degrading enzyme) Heterocephalus glaber
Analyze
Symbol: Ide
Name: insulin degrading enzyme
RGD ID: 18928722
Description: ENCODES a protein that exhibits amyloid-beta binding (ortholog); ATP binding (ortholog); ATP hydrolysis activity (ortholog); INVOLVED IN amyloid-beta clearance (ortholog); amyloid-beta clearance by cellular catabolic process (ortholog); amyloid-beta metabolic process (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Cognitive Dysfunction (ortholog); diabetic encephalopathy (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell surface (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: insulin-degrading enzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ide
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
IDE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,451,684 - 92,574,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,451,684 - 92,574,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36Build 36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
T2T-CHM13v2.01093,330,970 - 93,453,429 (-)NCBIT2T-CHM13v2.0
Ide
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,246,140 - 37,341,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,246,142 - 37,340,010 (-)EnsemblGRCm39 Ensembl
GRCm381937,268,743 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBIMGSCv36mm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
Ide
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,415,495 - 244,516,925 (-)NCBIGRCr8
mRatBN7.21235,002,984 - 235,102,448 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,995,351 - 235,102,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,391,715 - 243,489,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,321,195 - 250,419,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,159,390 - 243,257,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,914,465 - 256,014,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,914,447 - 256,013,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,389,549 - 263,489,002 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,547,869 - 241,646,052 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,737,460 - 241,835,644 (-)NCBI
Celera1232,095,058 - 232,193,208 (-)NCBICelera
Cytogenetic Map1q53NCBI
Ide
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425847,615 - 926,318 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955425819,461 - 926,440 (+)NCBIChiLan1.0ChiLan1.0
IDE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,487,164 - 104,615,627 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,492,478 - 104,617,589 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,196,295 - 89,320,223 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,714,343 - 92,833,430 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,716,540 - 92,833,353 (-)Ensemblpanpan1.1panPan2
IDE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,844,480 - 6,967,713 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,844,055 - 6,967,713 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,022,845 - 7,145,664 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,097,078 - 7,242,543 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,098,967 - 7,229,235 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,826,499 - 6,949,290 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,860,782 - 6,983,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,025,500 - 7,148,346 (-)NCBIUU_Cfam_GSD_1.0
Ide
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,597,592 - 40,685,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,230,283 - 2,318,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,230,477 - 2,318,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,992,039 - 104,106,576 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,992,035 - 104,106,571 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,505,034 - 113,619,303 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IDE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,722,728 - 85,843,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,721,886 - 85,843,117 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,459,858 - 46,578,672 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000017885   ⟹   ENSHGLP00000017710
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,835,776 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017886   ⟹   ENSHGLP00000017711
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,822,300 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017887   ⟹   ENSHGLP00000017712
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247373,702,985 - 3,822,300 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017888   ⟹   ENSHGLP00000017713
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247373,710,506 - 3,822,300 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000017889   ⟹   ENSHGLP00000017714
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247373,710,506 - 3,822,300 (-)Ensembl
RefSeq Acc Id: XM_021253050   ⟹   XP_021108709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247373,708,309 - 3,822,390 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021108709 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000017712
  ENSHGLP00000017714
  ENSHGLP00100029418
GenBank Protein JAO01414 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021108709   ⟸   XM_021253050
- UniProtKB: A0A0N8EU93 (UniProtKB/TrEMBL),   G5BV05 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000017712   ⟸   ENSHGLT00000017887
RefSeq Acc Id: ENSHGLP00000017710   ⟸   ENSHGLT00000017885
RefSeq Acc Id: ENSHGLP00000017714   ⟸   ENSHGLT00000017889
RefSeq Acc Id: ENSHGLP00000017713   ⟸   ENSHGLT00000017888
RefSeq Acc Id: ENSHGLP00000017711   ⟸   ENSHGLT00000017886


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000012665 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100002326 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000017887 UniProtKB/TrEMBL
  ENSHGLT00000017889 ENTREZGENE
  ENSHGLT00100066759 UniProtKB/TrEMBL
Gene3D-CATH Metalloenzyme, LuxS/M16 peptidase-like UniProtKB/TrEMBL
InterPro Metalloenz_LuxS/M16 UniProtKB/TrEMBL
  Pept_M16_N UniProtKB/TrEMBL
  Pept_M16_Zn_BS UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/TrEMBL
NCBI Gene Ide ENTREZGENE
PANTHER INSULIN-DEGRADING ENZYME-RELATED UniProtKB/TrEMBL
  NARDILYSIN UniProtKB/TrEMBL
Pfam Peptidase_M16 UniProtKB/TrEMBL
  Peptidase_M16_C UniProtKB/TrEMBL
  Peptidase_M16_M UniProtKB/TrEMBL
PROSITE INSULINASE UniProtKB/TrEMBL
Superfamily-SCOP SSF63411 UniProtKB/TrEMBL
UniProt A0A0N8EU93 ENTREZGENE, UniProtKB/TrEMBL
  G5BV05 ENTREZGENE, UniProtKB/TrEMBL