Btk (Bruton tyrosine kinase) - Rat Genome Database

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Gene: Btk (Bruton tyrosine kinase) Heterocephalus glaber
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Symbol: Btk
Name: Bruton tyrosine kinase
RGD ID: 18927429
Description: ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN B cell affinity maturation (ortholog); cell maturation (ortholog); cellular response to interleukin-7 (ortholog); PARTICIPATES IN erythropoietin signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Adenoviridae Infections (ortholog); agammaglobulinemia (ortholog); agammaglobulinemia 1 (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Tyrosine-protein kinase BTK
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Btk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
BTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,349,450 - 101,390,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,349,338 - 101,390,796 (-)EnsemblGRCh38hg38GRCh38
GRCh37X100,604,438 - 100,645,784 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,491,098 - 100,527,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X100,410,586 - 100,447,327NCBI
CeleraX101,123,894 - 101,160,669 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,410,583 - 90,447,505 (-)NCBIHuRef
CHM1_1X100,497,918 - 100,534,692 (-)NCBICHM1_1
T2T-CHM13v2.0X99,793,571 - 99,834,908 (-)NCBIT2T-CHM13v2.0
Btk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X133,443,083 - 133,484,366 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX133,443,085 - 133,484,319 (-)EnsemblGRCm39 Ensembl
GRCm38X134,542,334 - 134,583,628 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX134,542,336 - 134,583,570 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X131,076,880 - 131,117,679 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X129,888,761 - 129,929,466 (-)NCBIMGSCv36mm8
CeleraX117,421,885 - 117,462,725 (-)NCBICelera
Cytogenetic MapXE3NCBI
cM MapX56.18NCBI
Btk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,016,070 - 102,055,448 (-)NCBIGRCr8
mRatBN7.2X97,722,796 - 97,762,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX97,722,802 - 97,761,853 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX99,397,016 - 99,436,088 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X102,907,749 - 102,946,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X100,410,180 - 100,449,237 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X105,360,922 - 105,390,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX105,360,922 - 105,390,580 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X105,250,666 - 105,279,934 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X121,998,935 - 122,030,289 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X122,072,367 - 122,103,722 (-)NCBI
CeleraX98,764,036 - 98,794,122 (-)NCBICelera
Cytogenetic MapXq32NCBI
Btk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555037,482,793 - 7,515,120 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555037,483,819 - 7,515,085 (-)NCBIChiLan1.0ChiLan1.0
BTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X100,948,666 - 100,985,544 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X100,952,265 - 100,989,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X90,551,874 - 90,588,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X100,684,017 - 100,720,868 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX100,684,017 - 100,725,187 (-)Ensemblpanpan1.1panPan2
BTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X75,270,952 - 75,302,663 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX75,270,979 - 75,302,562 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X76,691,359 - 76,723,087 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX76,691,367 - 76,723,042 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X74,255,464 - 74,287,205 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X75,915,885 - 75,947,610 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X75,678,325 - 75,710,045 (-)NCBIUU_Cfam_GSD_1.0
Btk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X63,007,672 - 63,045,710 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936813429,224 - 463,441 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936813429,400 - 467,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX82,981,515 - 83,014,573 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X82,981,512 - 83,014,475 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X89,690,569 - 89,727,420 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606514,609,796 - 14,647,019 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000000779   ⟹   ENSHGLP00000000739
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,182,682 - 1,216,171 (+)Ensembl
RefSeq Acc Id: ENSHGLT00000000780   ⟹   ENSHGLP00000000740
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046249021,191,923 - 1,215,728 (+)Ensembl
RefSeq Acc Id: XM_004872573   ⟹   XP_004872630
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,173,125 - 1,216,662 (+)NCBI
RefSeq Acc Id: XM_021250481   ⟹   XP_021106140
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,191,422 - 1,216,662 (+)NCBI
RefSeq Acc Id: XM_021250482   ⟹   XP_021106141
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046249021,173,101 - 1,216,662 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004872630 (Get FASTA)   NCBI Sequence Viewer  
  XP_021106140 (Get FASTA)   NCBI Sequence Viewer  
  XP_021106141 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000739
  ENSHGLP00100024978
RefSeq Acc Id: XP_021106141   ⟸   XM_021250482
- Peptide Label: isoform X2
- UniProtKB: G5C2S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004872630   ⟸   XM_004872573
- Peptide Label: isoform X2
- UniProtKB: G5C2S6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021106140   ⟸   XM_021250481
- Peptide Label: isoform X1
RefSeq Acc Id: ENSHGLP00000000740   ⟸   ENSHGLT00000000780
RefSeq Acc Id: ENSHGLP00000000739   ⟸   ENSHGLT00000000779


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000626 Ensembl, ENTREZGENE
  ENSHGLG00100018333 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000000779 ENTREZGENE
  ENSHGLT00100025233 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro BTK_SH3 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Znf_Btk_motif UniProtKB/TrEMBL
KEGG Report hgl:101715242 UniProtKB/TrEMBL
NCBI Gene Btk ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE BTK UniProtKB/TrEMBL
Pfam BTK UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  TECBTKDOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_BTK UniProtKB/TrEMBL
SMART BTK UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt G5C2S6 ENTREZGENE, UniProtKB/TrEMBL