BTK (Bruton agammaglobulinemia tyrosine kinase)

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Keyword

Gene: BTK (Bruton agammaglobulinemia tyrosine kinase) Homo sapiens

Symbol:

BTK

Name:

Bruton agammaglobulinemia tyrosine kinase

Description:

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. [provided by RefSeq, Nov 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

agammaglobulinaemia tyrosine kinase; AGMX1; AT; ATK; B-cell progenitor kinase; BPK; dominant-negative kinase-deficient Brutons tyrosine kinase; IMD1; MGC126261; MGC126262; OTTHUMP00000023676; OTTHUMP00000023677; PSCTK1; tyrosine-protein kinase BTK; tyrosine-protein kinase BTK isoform (lacking exon 14); XLA

Orthologs:

Mus musculus : Btk (Bruton agammaglobulinemia tyrosine kinase) MGI
Rattus norvegicus : Btk (Bruton agammaglobulinemia tyrosine kinase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	X	100,571,433 - 100,608,208	-	NCBI
Human Genome Assembly HuRef	X	90,410,583 - 90,447,505	-	NCBI
Human Genome Assembly GRCh37	X	100,604,435 - 100,641,212	-	NCBI
Human Genome Assembly Build 36	X	100,491,098 - 100,527,838	-	NCBI
Human Cytogenetic Map	X	q21.33-q22		NCBI
Human Genome Assembly	X	100,410,586 - 100,447,327		NCBI