Tirap (TIR domain containing adaptor protein) - Rat Genome Database

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Gene: Tirap (TIR domain containing adaptor protein) Heterocephalus glaber
Analyze
Symbol: Tirap
Name: TIR domain containing adaptor protein
RGD ID: 18926091
Description: ENCODES a protein that exhibits molecular adaptor activity (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); protein kinase C binding (ortholog); INVOLVED IN 3'-UTR-mediated mRNA stabilization (ortholog); cell surface receptor signaling pathway (ortholog); cellular response to bacterial lipopeptide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH Bacteremia (ortholog); Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); FOUND IN cell surface (ortholog); endocytic vesicle (ortholog); extrinsic component of cytoplasmic side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: toll/interleukin-1 receptor domain-containing adapter protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624812439,319 - 446,646 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624812433,540 - 445,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA stabilization  (ISO)
canonical NF-kappaB signal transduction  (IEA)
cell surface receptor signaling pathway  (ISO)
cellular response to bacterial lipopeptide  (ISO)
cellular response to lipoteichoic acid  (ISO)
defense response to Gram-positive bacterium  (ISO)
inflammatory response  (IEA)
innate immune response  (IEA)
interleukin-1-mediated signaling pathway  (ISO)
myeloid cell differentiation  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of chemokine (C-X-C motif) ligand 1 production  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-15 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 3 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO)
regulation of innate immune response  (IEA)
regulation of interferon-beta production  (ISO)
regulation of interleukin-15 production  (ISO)
regulation of stress-activated MAPK cascade  (IEA)
response to lipopolysaccharide  (ISO)
signal transduction  (IEA)
TIRAP-dependent toll-like receptor 4 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (IEA)
toll-like receptor 5 signaling pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Tirap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624812439,319 - 446,646 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624812433,540 - 445,517 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TIRAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811126,283,093 - 126,294,933 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11126,282,497 - 126,298,845 (+)EnsemblGRCh38hg38GRCh38
GRCh3711126,152,988 - 126,164,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611125,658,192 - 125,670,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera11123,318,165 - 123,330,030 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11122,098,046 - 122,109,916 (+)NCBIHuRef
CHM1_111126,039,258 - 126,051,104 (+)NCBICHM1_1
T2T-CHM13v2.011126,314,493 - 126,326,362 (+)NCBIT2T-CHM13v2.0
Tirap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39935,095,687 - 35,111,587 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl935,095,847 - 35,111,587 (-)EnsemblGRCm39 Ensembl
GRCm38935,184,391 - 35,200,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl935,184,551 - 35,200,291 (-)EnsemblGRCm38mm10GRCm38
MGSCv37934,991,976 - 35,007,876 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36934,936,435 - 34,949,545 (-)NCBIMGSCv36mm8
Celera932,421,410 - 32,437,270 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map919.99NCBI
Tirap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8841,789,557 - 41,805,903 (-)NCBIGRCr8
mRatBN7.2833,531,724 - 33,548,508 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl833,531,725 - 33,547,432 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0836,382,029 - 36,399,625 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl836,385,353 - 36,388,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0836,400,673 - 36,406,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4834,966,856 - 34,969,727 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera834,950,692 - 34,968,852 (-)NCBICelera
Cytogenetic Map8q21NCBI
Tirap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541227,312,489 - 27,315,031 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541227,303,548 - 27,315,031 (+)NCBIChiLan1.0ChiLan1.0
TIRAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29126,969,695 - 126,984,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111128,077,374 - 128,092,151 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011121,100,558 - 121,112,844 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111125,018,064 - 125,022,309 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11125,018,064 - 125,022,309 (+)Ensemblpanpan1.1panPan2
TIRAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.158,222,217 - 8,237,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl58,221,794 - 8,226,074 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha58,275,792 - 8,300,808 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.058,170,182 - 8,195,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,176,896 - 8,181,685 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.158,239,756 - 8,264,804 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.058,213,520 - 8,238,550 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.058,247,729 - 8,272,742 (-)NCBIUU_Cfam_GSD_1.0
Tirap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947108,511,610 - 108,526,005 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365725,924,158 - 5,938,658 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365725,926,193 - 5,938,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIRAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl953,375,644 - 53,394,165 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1953,374,559 - 53,394,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2959,036,463 - 59,057,589 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TIRAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11117,417,561 - 117,419,870 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660438,650,207 - 8,662,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000004575   ⟹   ENSHGLP00000004513
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624812439,319 - 446,646 (+)Ensembl
RefSeq Acc Id: XM_021242771   ⟹   XP_021098430
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242772   ⟹   XP_021098431
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242773   ⟹   XP_021098432
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242774   ⟹   XP_021098433
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242775   ⟹   XP_021098434
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242776   ⟹   XP_021098435
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242777   ⟹   XP_021098436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XM_021242778   ⟹   XP_021098437
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 444,527 (+)NCBI
RefSeq Acc Id: XR_002388768
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624812433,540 - 445,517 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021098435   ⟸   XM_021242776
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098434   ⟸   XM_021242775
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098430   ⟸   XM_021242771
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098432   ⟸   XM_021242773
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098433   ⟸   XM_021242774
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098431   ⟸   XM_021242772
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098436   ⟸   XM_021242777
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021098437   ⟸   XM_021242778
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JU58 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000004513   ⟸   ENSHGLT00000004575


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003302 Ensembl, ENTREZGENE
  ENSHGLG00000032073 UniProtKB/TrEMBL
  ENSHGLG00100038401 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004575 ENTREZGENE
  ENSHGLT00000071089 UniProtKB/TrEMBL
  ENSHGLT00100042538 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
InterPro TIR_dom UniProtKB/TrEMBL
  Tol-interleuk_rcpt_adapt_Tirap UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene Tirap ENTREZGENE
PANTHER PTHR22662 UniProtKB/TrEMBL
  TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN UniProtKB/TrEMBL
Pfam TIR_2 UniProtKB/TrEMBL
PIRSF TIR_Tirap UniProtKB/TrEMBL
PROSITE TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A0P6JU58 ENTREZGENE, UniProtKB/TrEMBL