LOC101704598 (cholesterol side-chain cleavage enzyme, mitochondrial) - Rat Genome Database

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Pathways
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Gene: LOC101704598 (cholesterol side-chain cleavage enzyme, mitochondrial) Heterocephalus glaber
Analyze
Symbol: LOC101704598 (Ensembl: CYP11A1)
Name: cholesterol side-chain cleavage enzyme, mitochondrial
RGD ID: 18918621
Description: ENCODES a protein that exhibits cholesterol monooxygenase (side-chain-cleaving) activity (inferred); heme binding (inferred); iron ion binding (inferred); INVOLVED IN biphenyl metabolic process (ortholog); C21-steroid hormone biosynthetic process (ortholog); cellular response to antibiotic (ortholog); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; ASSOCIATED WITH 46, XY Disorders of Sex Development (ortholog); Adrenal Insufficiency (ortholog); autism spectrum disorder (ortholog); FOUND IN mitochondrial crista (ortholog); mitochondrial inner membrane (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP11A1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781288,594 - 300,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781288,594 - 298,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biphenyl metabolic process  (ISO)
C21-steroid hormone biosynthetic process  (IEA,ISO)
C21-steroid hormone metabolic process  (IEA)
cellular response to antibiotic  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to cAMP  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to gonadotropin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to peptide hormone stimulus  (IEA,ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cerebellum development  (ISO)
cholesterol metabolic process  (IEA)
cortisol metabolic process  (IEA)
dibenzo-p-dioxin metabolic process  (ISO)
glucocorticoid biosynthetic process  (IEA)
granulosa cell differentiation  (ISO)
hippocampus development  (ISO)
hormone biosynthetic process  (IEA)
Leydig cell differentiation  (ISO)
male gonad development  (ISO)
maternal process involved in female pregnancy  (ISO)
mating behavior  (ISO)
organic acid metabolic process  (ISO)
phenol-containing compound metabolic process  (ISO)
phthalate metabolic process  (ISO)
response to alkaloid  (ISO)
response to amino acid  (ISO)
response to cadmium ion  (ISO)
response to cAMP  (ISO)
response to corticosterone  (ISO)
response to estrogen  (ISO)
response to fungicide  (ISO)
response to gamma radiation  (ISO)
response to genistein  (ISO)
response to gonadotropin  (ISO)
response to hydrogen peroxide  (ISO)
response to insecticide  (ISO)
response to ionizing radiation  (ISO)
response to L-ascorbic acid  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to salt stress  (ISO)
response to steroid hormone  (ISO)
response to vitamin E  (ISO)
response to xenobiotic stimulus  (ISO)
Schwann cell differentiation  (ISO)
steroid biosynthetic process  (IEA,ISO)
testosterone biosynthetic process  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC101704598
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781288,594 - 300,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781288,594 - 298,876 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CYP11A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,337,762 - 74,367,646 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,337,759 - 74,367,646 (-)EnsemblGRCh38hg38GRCh38
GRCh371574,630,103 - 74,659,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,417,156 - 72,447,134 (-)NCBINCBI36Build 36hg18NCBI36
Build 341572,417,156 - 72,447,020NCBI
Celera1551,578,744 - 51,607,311 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,425,968 - 51,455,911 (-)NCBIHuRef
CHM1_11574,748,248 - 74,778,221 (-)NCBICHM1_1
T2T-CHM13v2.01572,205,513 - 72,235,390 (-)NCBIT2T-CHM13v2.0
Cyp11a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,905,307 - 57,934,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,913,694 - 57,934,306 (+)EnsemblGRCm39 Ensembl
GRCm38957,998,024 - 58,027,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,006,411 - 58,027,023 (+)EnsemblGRCm38mm10GRCm38
MGSCv37957,862,824 - 57,874,830 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,813,153 - 57,825,158 (+)NCBIMGSCv36mm8
Celera955,247,551 - 55,259,829 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.63NCBI
Cyp11a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8867,318,665 - 67,330,196 (+)NCBIGRCr8
mRatBN7.2858,422,807 - 58,434,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,404,669 - 58,434,338 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,953,220 - 63,964,751 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0862,230,774 - 62,242,305 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,095,340 - 60,106,871 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,798,317 - 62,809,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,779,875 - 62,809,893 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,525,349 - 62,585,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,793,976 - 61,805,308 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,812,986 - 61,824,536 (+)NCBI
Celera857,887,124 - 57,898,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
LOC102014960
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,474,491 - 3,484,232 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,433,310 - 3,484,462 (+)NCBIChiLan1.0ChiLan1.0
CYP11A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,565,244 - 63,596,156 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11567,728,964 - 67,759,712 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,280,110 - 53,310,868 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11572,901,274 - 72,931,614 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1572,901,286 - 72,931,164 (-)Ensemblpanpan1.1panPan2
CYP11A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,474,997 - 37,487,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,473,901 - 37,487,507 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,409,316 - 37,421,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03037,680,903 - 37,692,929 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,677,046 - 37,692,855 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,633,421 - 37,645,467 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,658,685 - 37,670,696 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,914,475 - 37,926,521 (-)NCBIUU_Cfam_GSD_1.0
LOC101975820
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,519,508 - 115,532,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,367,810 - 33,380,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,367,810 - 33,380,764 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP11A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl759,175,758 - 59,188,478 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1759,172,829 - 59,188,479 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP11A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1269,122,008 - 9,151,844 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048132,473,434 - 132,503,785 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000023101   ⟹   ENSHGLP00000022887
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624781288,594 - 300,429 (+)Ensembl
RefSeq Acc Id: XM_004855473   ⟹   XP_004855530
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624781288,594 - 298,876 (+)NCBI
RefSeq Acc Id: XM_021236914   ⟹   XP_021092573
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624781290,885 - 298,876 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004855530 (Get FASTA)   NCBI Sequence Viewer  
  XP_021092573 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000022887
  ENSHGLP00100004628
GenBank Protein JAO02347 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004855530   ⟸   XM_004855473
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JD65 (UniProtKB/TrEMBL),   G5BRG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092573   ⟸   XM_021236914
- Peptide Label: isoform X2
RefSeq Acc Id: ENSHGLP00000022887   ⟸   ENSHGLT00000023101


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016326 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100003494 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000023101 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00100004697 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report hgl:101704598 UniProtKB/TrEMBL
NCBI Gene LOC101704598 ENTREZGENE
PANTHER PTHR24279 UniProtKB/TrEMBL
  PTHR24279:SF3 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0P6JD65 ENTREZGENE, UniProtKB/TrEMBL
  G5BRG4 ENTREZGENE, UniProtKB/TrEMBL