Tp73 (tumor protein p73) - Rat Genome Database

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Pathways
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Gene: Tp73 (tumor protein p73) Heterocephalus glaber
Analyze
Symbol: Tp73
Name: tumor protein p73
RGD ID: 18908039
Description: ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN cerebrospinal fluid secretion (ortholog); digestive tract morphogenesis (ortholog); DNA damage response (ortholog); PARTICIPATES IN altered p53 signaling pathway; Ras mediated signaling pathway; ASSOCIATED WITH adenoma (ortholog); adult T-cell leukemia/lymphoma (ortholog); alveolar rhabdomyosarcoma (ortholog); FOUND IN cell junction (ortholog); chromatin (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248186,775,599 - 6,809,289 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248186,775,588 - 6,817,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cerebrospinal fluid secretion  (ISO)
digestive tract morphogenesis  (ISO)
DNA damage response  (ISO)
forebrain development  (ISO)
hippocampus development  (ISO)
inflammatory response  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
kidney development  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
neuron development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
positive regulation of lung ciliated cell differentiation  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-embryonic development  (ISO)
protein tetramerization  (IEA)
regulation of cell cycle  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of mitotic cell cycle  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
response to organonitrogen compound  (ISO)
response to xenobiotic stimulus  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tp73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248186,775,599 - 6,809,289 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248186,775,588 - 6,817,187 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
TP73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813,652,516 - 3,736,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13,652,516 - 3,736,201 (+)EnsemblGRCh38hg38GRCh38
GRCh3713,569,080 - 3,652,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613,558,989 - 3,639,716 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413,592,285 - 3,673,013NCBI
Celera12,823,557 - 2,904,508 (+)NCBICelera
Cytogenetic Map1p36.32NCBI
HuRef12,864,839 - 2,947,956 (+)NCBIHuRef
CHM1_113,555,405 - 3,639,797 (+)NCBICHM1_1
T2T-CHM13v2.013,162,389 - 3,247,802 (+)NCBIT2T-CHM13v2.0
Trp73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394154,140,706 - 154,224,332 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4154,140,706 - 154,224,665 (-)EnsemblGRCm39 Ensembl
GRCm384154,056,249 - 154,139,875 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,056,249 - 154,140,208 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl4154,056,253 - 154,140,208 (-)EnsemblGRCm38mm10GRCm38
MGSCv374153,430,358 - 153,514,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364152,902,644 - 152,984,008 (-)NCBIMGSCv36mm8
Celera4156,338,953 - 156,424,405 (-)NCBICelera
Cytogenetic Map4E2NCBI
cM Map483.79NCBI
Tp73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85169,903,801 - 169,988,075 (-)NCBIGRCr8
mRatBN7.25164,621,377 - 164,703,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5164,621,377 - 164,681,128 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5167,325,484 - 167,385,231 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05169,146,894 - 169,206,634 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05169,109,342 - 169,169,082 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05171,355,876 - 171,415,354 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5171,355,876 - 171,415,354 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05174,889,051 - 174,901,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.05174,843,033 - 174,868,415 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45170,848,979 - 171,078,739 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15170,861,458 - 170,885,614 (-)NCBI
Celera5162,833,132 - 162,892,871 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tp73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554867,914,440 - 7,952,982 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554867,914,608 - 7,961,992 (-)NCBIChiLan1.0ChiLan1.0
TP73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21224,577,312 - 224,657,001 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,216,998 - 223,301,768 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012,323,399 - 2,405,295 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113,476,064 - 3,529,206 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13,476,064 - 3,529,206 (+)Ensemblpanpan1.1panPan2
TP73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1558,194,385 - 58,241,159 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl558,187,826 - 58,240,839 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha558,188,725 - 58,251,651 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0558,379,191 - 58,448,746 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1558,393,659 - 58,456,555 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0558,262,432 - 58,325,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0558,652,679 - 58,715,711 (+)NCBIUU_Cfam_GSD_1.0
Tp73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505829,244,172 - 29,294,165 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936737172,467 - 211,464 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936737171,894 - 211,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl665,182,456 - 65,228,990 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1665,169,770 - 65,228,997 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2659,826,402 - 59,869,412 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TP73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120127,958,002 - 128,035,792 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20127,958,809 - 128,013,691 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605432,183,910 - 32,243,642 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000021688   ⟹   ENSHGLP00000021479
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248186,775,599 - 6,804,266 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000021689   ⟹   ENSHGLP00000021480
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248186,776,150 - 6,809,289 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000021690   ⟹   ENSHGLP00000021481
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248186,776,150 - 6,804,055 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000021691   ⟹   ENSHGLP00000021482
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046248186,776,470 - 6,804,055 (-)Ensembl
RefSeq Acc Id: XM_004863761   ⟹   XP_004863818
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248186,776,150 - 6,817,187 (-)NCBI
RefSeq Acc Id: XM_013065072   ⟹   XP_012920526
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248186,775,588 - 6,804,282 (-)NCBI
RefSeq Acc Id: XM_021243594   ⟹   XP_021099253
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046248186,776,150 - 6,783,052 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004863818 (Get FASTA)   NCBI Sequence Viewer  
  XP_012920526 (Get FASTA)   NCBI Sequence Viewer  
  XP_021099253 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB18897 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000021479
  ENSHGLP00000021480
  ENSHGLP00100024519
GenBank Protein JAO00182 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_012920526   ⟸   XM_013065072
- Peptide Label: isoform X1
RefSeq Acc Id: XP_004863818   ⟸   XM_004863761
- Peptide Label: isoform X2
- UniProtKB: G5CBI6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021099253   ⟸   XM_021243594
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000021480   ⟸   ENSHGLT00000021689
RefSeq Acc Id: ENSHGLP00000021481   ⟸   ENSHGLT00000021690
RefSeq Acc Id: ENSHGLP00000021482   ⟸   ENSHGLT00000021691
RefSeq Acc Id: ENSHGLP00000021479   ⟸   ENSHGLT00000021688


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000015349 Ensembl, ENTREZGENE
  ENSHGLG00100018005 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000021688 ENTREZGENE
  ENSHGLT00000021689 ENTREZGENE
  ENSHGLT00100024770 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.720 UniProtKB/TrEMBL
  4.10.170.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/TrEMBL
  p53_DNA-bd UniProtKB/TrEMBL
  p53_tetramer_sf UniProtKB/TrEMBL
  p53_tetrameristn UniProtKB/TrEMBL
  p53_tumour_suppressor UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Tumour-p73_SAM UniProtKB/TrEMBL
KEGG Report hgl:101716466 UniProtKB/TrEMBL
NCBI Gene Tp73 ENTREZGENE
PANTHER PTHR11447 UniProtKB/TrEMBL
  PTHR11447:SF21 UniProtKB/TrEMBL
Pfam P53 UniProtKB/TrEMBL
  P53_tetramer UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PRINTS P53SUPPRESSR UniProtKB/TrEMBL
PROSITE P53 UniProtKB/TrEMBL
SMART SAM UniProtKB/TrEMBL
Superfamily-SCOP SSF47719 UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
UniProt G5CBI6 ENTREZGENE, UniProtKB/TrEMBL