RGD Reference Report - p73 mutations are not detected in sporadic and hereditary breast cancer. - Rat Genome Database

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p73 mutations are not detected in sporadic and hereditary breast cancer.

Authors: Schwartz, DI  Lindor, NM  Walsh-Vockley, C  Roche, PC  Mai, M  Smith, DI  Liu, W  Couch, FJ 
Citation: Schwartz DI, etal., Breast Cancer Res Treat. 1999 Nov;58(1):25-9.
RGD ID: 2291835
Pubmed: PMID:10634515   (View Abstract at PubMed)

Recently, a novel tumor suppressor gene, p73, was isolated and mapped to chromosome 1p36, a region commonly associated with loss of heterozygosity in neuroblastoma and other human malignancies, including breast cancer. The p73 gene shares considerable homology with the common tumor suppressor gene p53, both in composition and function. This study examines the potential participation of p73 in the pathogenesis of sporadic and hereditary breast cancers. Mutation analysis of 29 hereditary breast cancer cases revealed five independent silent mutations in the hereditary cases that are unlikely to play a role in tumor development. Mutation analysis of 48 sporadic breast tumors did not identify any unique variants. Eleven common polymorphisms scattered throughout the gene were also detected. Thus, mutations in the p73 gene appear to play little if any role in hereditary or sporadic breast cancer.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP73Humanbreast cancer no_associationIAGP DNA:mutationsRGD 
Tp73Ratbreast cancer no_associationISOTP73 (Homo sapiens)DNA:mutationsRGD 
Trp73Mousebreast cancer no_associationISOTP73 (Homo sapiens)DNA:mutationsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
TP73  (tumor protein p73)


Additional Information