SPTAN1 (spectrin alpha, non-erythrocytic 1) - Rat Genome Database

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Gene: SPTAN1 (spectrin alpha, non-erythrocytic 1) Chlorocebus sabaeus
Analyze
Symbol: SPTAN1
Name: spectrin alpha, non-erythrocytic 1
RGD ID: 18710667
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); spectrin binding (ortholog); INVOLVED IN actin cytoskeleton organization (inferred); actin filament capping (inferred); ASSOCIATED WITH asphyxiating thoracic dystrophy (ortholog); autism spectrum disorder (ortholog); autosomal dominant distal hereditary motor neuronopathy 11 (ortholog); FOUND IN cortical cytoskeleton (ortholog); cuticular plate (ortholog); fascia adherens (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: spectrin alpha chain, non-erythrocytic 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,503,752 - 9,585,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,503,367 - 9,585,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SPTAN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,503,752 - 9,585,297 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,503,367 - 9,585,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SPTAN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,552,587 - 128,633,662 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,552,558 - 128,633,662 (+)EnsemblGRCh38hg38GRCh38
GRCh379131,314,866 - 131,395,941 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,354,687 - 130,435,762 (+)NCBINCBI36Build 36hg18NCBI36
Build 349128,394,439 - 128,475,426NCBI
Celera9101,965,660 - 102,046,740 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,926,750 - 101,007,765 (+)NCBIHuRef
CHM1_19131,465,810 - 131,546,871 (+)NCBICHM1_1
T2T-CHM13v2.09140,759,427 - 140,840,530 (+)NCBIT2T-CHM13v2.0
Sptan1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,855,572 - 29,921,463 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl229,855,572 - 29,921,463 (+)EnsemblGRCm39 Ensembl
GRCm38229,965,560 - 30,031,451 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,965,560 - 30,031,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv37229,821,080 - 29,886,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36229,787,569 - 29,853,460 (+)NCBIMGSCv36mm8
Celera229,669,500 - 29,735,203 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map220.93NCBI
Sptan1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8333,639,020 - 33,703,890 (+)NCBIGRCr8
mRatBN7.2313,241,164 - 13,306,047 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,241,217 - 13,306,046 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx316,315,861 - 16,380,393 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0324,900,818 - 24,965,352 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,151,547 - 23,216,077 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,534,437 - 8,599,259 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,534,440 - 8,599,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0313,878,433 - 13,950,970 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,956,380 - 9,021,831 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.138,956,679 - 9,022,131 (+)NCBI
Celera38,018,277 - 8,083,081 (+)NCBICelera
Cytogenetic Map3p12NCBI
Sptan1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,016,510 - 1,076,499 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555701,016,510 - 1,076,499 (+)NCBIChiLan1.0ChiLan1.0
SPTAN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,718,343 - 10,799,503 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,720,693 - 10,801,863 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,674,819 - 99,755,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,341,739 - 128,422,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,341,739 - 128,422,971 (+)Ensemblpanpan1.1panPan2
SPTAN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,953,751 - 55,015,475 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,953,747 - 55,015,376 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,149,445 - 54,211,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0955,876,077 - 55,937,766 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,876,080 - 55,937,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,635,563 - 54,694,357 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,949,366 - 55,011,369 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,041,985 - 55,103,647 (-)NCBIUU_Cfam_GSD_1.0
Sptan1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,302,505 - 196,374,135 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,070,996 - 16,142,662 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,071,043 - 16,142,662 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPTAN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,936,025 - 269,002,256 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,936,120 - 269,002,261 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,959,613 - 303,025,990 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sptan1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,331,554 - 6,386,216 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247606,331,554 - 6,388,953 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000012372   ⟹   ENSCSAP00000010407
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl129,503,367 - 9,585,268 (-)Ensembl
RefSeq Acc Id: XM_008006036   ⟹   XP_008004227
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1129,503,752 - 9,585,297 (-)NCBI
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008006038   ⟹   XP_008004229
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1129,503,752 - 9,585,297 (-)NCBI
Vero_WHO_p1.0NW_0236660796,662,945 - 6,746,597 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008006039   ⟹   XP_008004230
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1129,503,752 - 9,585,163 (-)NCBI
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,590 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008006040   ⟹   XP_008004231
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1129,503,752 - 9,585,265 (-)NCBI
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,590 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008006041   ⟹   XP_008004232
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1129,503,752 - 9,585,297 (-)NCBI
Vero_WHO_p1.0NW_0236660796,662,808 - 6,746,597 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008004227 (Get FASTA)   NCBI Sequence Viewer  
  XP_008004229 (Get FASTA)   NCBI Sequence Viewer  
  XP_008004230 (Get FASTA)   NCBI Sequence Viewer  
  XP_008004231 (Get FASTA)   NCBI Sequence Viewer  
  XP_008004232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010407.1
Reference Protein Sequences
RefSeq Acc Id: XP_008004232   ⟸   XM_008006041
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008004229   ⟸   XM_008006038
- Peptide Label: isoform X5
RefSeq Acc Id: XP_008004227   ⟸   XM_008006036
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008004231   ⟸   XM_008006040
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008004230   ⟸   XM_008006039
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000010407   ⟸   ENSCSAT00000012372


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014277 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012372.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Alpha_Spectrin_SH3 UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report csab:103239794 UniProtKB/TrEMBL
NCBI Gene SPTAN1 ENTREZGENE
PANTHER SPECTRIN ALPHA CHAIN UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PRINTS SH3DOMAIN UniProtKB/TrEMBL
  SPECTRNALPHA UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9RP68_CHLSB UniProtKB/TrEMBL